Cardiovascular Diseases - Heart Failure and Valvular Heart Diseases Flashcards
most common cause of systolic dysfunction that leads to left-sided heart failure
Coronary Artery Disease (CAD)
most common cause of diastolic dysfunction that leads to left-sided heart failure
Concentric Left Ventricular Hypertrophy (LVH) due to HPN
most common cause of right-sided heart failure
L-sided heart failure
Earliest CARDINAL SYMPTOM of L-sided heart failure
Dyspnea
Earliest CARDINAL SIGN of L-sided heart failure
L-sided S3
Presentation of L-sided heart failure
- Dyspnea
- L-sided S3
- PND
- Orthopnea
- MV regurgitation
- presence of brain natriuretic peptide (BNP)
- siderophages (hemosiderin-laden macrophages or heart failure cells)
- pulmonary edema (septal edema, peribronchiolar edema)
Presentation of R-sided heart failure
- peripheral ankle edema (hallmark of R-sided heart failure)
- neck vein engorgement
- tricuspid regurgitation
- ascites
- chronic passive congestion of the liver (nutmeg liver, cardiac cirrhosis)
MOST sensitive index of cardiac function
ejection fraction
important bedside measurement to estimate the volume status
JVP (internal jugular vein preferred)
predominant cause of HF and responsible for 60-75% of HF in industrialized countries
Coronary Artery Disease
Cardinal symptoms of heart failure
fatigue and shortness of breath
most important mechanism of dyspnea in heart failure
pulmonary congestion with accumulation of insterstitial or intra-alveolar fluid, which activates juxtacapillary J receptors
most useful test in assessment of LV function
2d-echo with doppler studies
gold standard for assessment of LV mass and volume
MRI
only pharmacologic agents that can adequately control fluid retention in advanced HF
diuretics
major problem in aldosterone antagonists
development of life-threatening hyperkalemia
cornerstones of moden therapy for HP with a depressed EF
ACE-I/ARBs and Beta Blockers