Cardiovascular Flashcards
All lecture content other then Histology, critical numbers and public health
What is the the haemocrit for blood?
45% cellular component of blood.
what is the fluid component of blood?
55%
What lies between the red blood cell and fluid layers on a haemocrit?
it is the white blood cells and platelets.
Where is haemopoesis in utero?
the yolk sac, liver and spleen, and bone marrow.
Where is haemopoesis in children?
in all bones in the bone marrow
Where in adults is haemopoesis?
in the axial skeleton. the spine and skull
What is the name for production of RBCs?
Erythropoeisis?
What is the name for production of which blood cells?
Myelopoiesis
What is the name for the production of Platelets?
Thrombopoesis
What cells does a common myeloid progenitoro lead to?
Megakaryocytes, erythrocytes, mast cells, myeloblasts
What do myeloblasts lead to?
Basophils, neutrophils, eosinophils, and monocytes.
What do common lympnoid proogenitors lead to?
lymphocytes
What growth factor causes RBC production?
Erythropoietin
What growth factor causes white blood cell production?
Granulocyte-macrophage-colony-stimulating factor
Which growth factor stimulates growth of platelets?
Thrombopoietin
Facts about RBCs?
simple cells no nucleus, no mitochondria, Biconcave disk around 7.5um contai haemoglobin and glycolysis enzymes.
Describe the haemoglobin molecule
quaternary structure. 2 alpha chains 2 beta chains. contain Fe2+ in haem group
What are the types of haemoblobin in an adult and proportions?
HbA 2 alpha 2 beta, 96-98%, HbF 2 alpha 2 gamma 0.5-0.8%, HbA2 2 alpha 2 delta 1.5-3.2%
What are the signs and symptoms of anaemia?
signs pallor tachycardia, signs related to underlying cause. symptoms tiredness/lethargy shortness of breath on exertion angina claudications symptoms related to underlying cause.
What changes in acute blood loss?
Volume of blood no change to haemocrit as all components lost equally.
How long do RBCs last for?
120 days aproximately 9 billion in an hour.
Which organs are involved in the removal of RBCs?
Spleen, Liver Bone marrow
Hypoplastic
not enough
Dyshaemopoietic
ineffective production