cardiovascular Flashcards
Name the three layers of a typical blood vessel
- Tunica intima
- Tunica media
- Tunica adventitia
Which layer of a blood vessel will you find the endothelial cells?
Tunica intima
What is the tunica media made of? (type of muscle and including what else)
Made up of smooth muscle, with elastic and collagen
What kind of fibres are found on the tunica adventitia?
Sympathetic fibres
Why do we have tight junctions in the endothelium?
To allow the crossing of small molecules and water, but holding plasma and blood cells within the vessel
Which blood vessel layer creates nitric oxide?
Endothelium
What are the jobs of the glycocalyx?
- to sense sheer blood stress against the walls of the vessel
- lubricates the red blood calls as they prepare to go into a single file and cross the capillary
Name 2 condition that can damage the glycocalyx, and which disease does this start?
- insulin resistance
- inflammation
- start of atherosclerosis
Name 3 key functions of the endothelium
- Semi-permeable barrier (fluid balance, selective movement of substrates)
- Homeostasis
- Immune defense
What are 3 roles of nitric oxide in the cardiovascular system
- Inhibits leukocyte adhesion
- Apposes oxidation of LDLs
- Regulates vascular tone
Where is nitric oxide secreted
The endothelium
What do PPAR’s do to HDL and triglycerides?
HDL - increase
triglycerides - decrease
What 2 places can we find PPAR’s?
In the cardiac tissue and in BAT (brown adipose tissue)
Which condition can PPAR gamma improve?
Insulin resistance
name 3 CVD risk factors
- genetics
- family history
- ethnicity
- gender
Why is elevated homocysteine a CVD risk factor?
- associated with LDL oxidation
- monocyte disfunction
- causes endothelium disfunction
What can cause high homocysteine levels?
- low B12 and folate (needed for remethylation of homocysteine to methionine)
- ## genetic polymorphism (MTHFR)
How is nitric oxide generated?
from L-arginine via the enzyme eNOS (endothelial nitric oxide synthase)
What does PPAR stand for
Peroxisome proliferator-activated receptor
What do PPARs do?
- decrease inflammation
- promote ED health
- balances lipid profile
How do PPARs balance lipid profiles?
- enhances HDL
- lowers triglycerides
How can you naturally enhance PPARs
- green tea
- oregano
- thyme
- roesmary
Name 3 genes that can cause cardio vascular disease if they have a SNP
- MTHFR
- NOS3
- MnSOD
- ACE
What does elevated Endothelin-1 (ET-1) lead to?
vasoconstriction leading to high BP
What are some CV symptoms of high Leptin?
- high heart rate
- high BP
- Sodium retention
- vasoconstriction of vessels
The thickness of which layers of the heart are directly impacted by insulin resistance?
Tunica media and tunica intima
Name some risk factors for cardiovascular disease
- Dyslipidaemia
- Family history
- Genetics
- Gender
- Hypertension
- Mitochondrial dysfunction
- Elevated homeocystine
Which SNP is associated to CVD and how?
- MTHFR: impacts supply of methyl groups
needed to methylate B12 in the methionine cycle
How is obesity linked to CVD?
- Inflammation is linked with ↑ endothelin-1 (ET-1),
a potent vasoconstrictor peptide. Elevated ET-1
leads to fibrosis of VSMCs and ↑ ROS. - Adiponectin is decreased in obesity.
- Adiponectin also ↑ insulin sensitivity, thus low
levels contribute to insulin resistance. - Obesity is associated with high levels of leptin, which activates the
SNS causing sodium retention, vasoconstriction & ↑ blood pressure.
How does insulin resistance cause CVD?
Generates chronic hyperglycaemia
leading to oxidative stress, inflammation and cellular damage.
Explain Advanced glycation end products (AGEs)
Harmful compounds
formed when protein or lipids becomes glycated after exposure to glucose.
In which 2 ways to AGEs exert their effects?
Receptor mediated: Bind to the RAGE receptor on cells (like endothelial cells, smooth muscle cells, and immune cells), leading to increased inflammatory cytokines and ROS
Non- receptor mediated: Increased EC matrix synthesis, trapping
ED LDL and cross binding with collagen (vascular stiffening).
What do AGEs lead to?
oxidative stress, vascular ED and immune cell dysfunction.
Name some causes of AGEs:
- Highly refined carbs, processed foods, meat and dairy
- High heat, grilling, roasting,
searing / frying - Smoking and sedentary lifestyles
Alterations in the gut microbiota cause what leading to CVD?
- increase in harmful metabolites such as trimethylamine-N-oxide (TMAO).
What is TMAO associated with in the ED?
TMAO is
associated with endothelial dysfunction and increased risk of CVD
Why is PRAL a dietary consideration in CV disease
Foods rich in protein (meat and cheese) may induce low grade metabolic acidosis
Why are trans fats a dietary consideration in CV disease
- promote dyslipidaemia (high LDL and TGS, low HDL)
- increase inflammation, contribute to ED disfunction
-encourage visceral adiposity and increase risk of IR
Why is fructose a dietary consideration in CV disease
- increase risk of de novo lypogenesis
- increase fatty acids (palmitic acid)
Which nutritional defiencies are a dietary consideration in CV disease
- vitamin C
- D
- E
- CoQ10
- Mg
Why is increased palmitic acid a risk for CV disease
it’s a major driver of atherosclerosis and coronary artery disease
Explain the cardiac risk tools (CV test)
calculate score based
on CV risks e.g., age, BMI, smoking.
Explain cardiac troponin (CV test)
Cardiac troponin proteins hs-cTnT and hs-cTnI are released into the blood when heart muscle is damaged
Explain Lp-PLA 2 (CV test)
Enzyme produced by monocytes, macrophages, T-cells. Upregulated in atherosclerotic plaques and vascular inflammation.
Explain hsCRP (CV test)
Inhibits NO and e-NOS and is involved in plaque deposition.
Explain MPO (CV test)
Released by macrophages and measures the body’s response to damaged arterial walls. High MPO is associated with inflammation / oxidative stress and a poor prognosis.
Which diet is associated with CVD
Plant based and Mediterranean diet
Why is the mediterranean diet helpful with CVD
- lowers inflammatory mediators
- reduces adiposity
- reduces risk of thrombosis
- increased SCFAs
- improved insulin sensitivity
- increased adiponectin
- improved ED function