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Farmacologie > Cardiovasculaire geneesmiddelen > Flashcards

Cardiovasculaire geneesmiddelen Flashcards

1
Q

Pimobendan

A

positief inotroop geneesmiddel of inodilatator
verhoogde CO
vasodilatorisch
hartinsufficiënte (DCM, Mitralisins)

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2
Q

Enalapril

A

ACE-I
prodrug enalaprilat
hartfalen, hypertensie hond, chronische nierins kat

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3
Q

Benazepril

A

ACEI
prodrug benazeprilat
hartfalen, hypertensie hond, chronische nierins kat
via lever deels geklaard beter bij nierinsuf

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4
Q

Ramipril en imidapril

A

ACEI
prodrugs
hartfalen, hypertensie hond, chronische nierins kat

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5
Q

Captopril en lisinopril

A

ACEI
geen prodrugs -> leverinsufficiëntie
hartfalen, hypertensie hond, chronische nierins kat

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6
Q

Telmisartan

A

sartaan
antagonist angiotensine II-R1
chronische nierins kat
systemische hypertensie
synergistisch met amlodipine (hypertensie kat)
GEEN combo met ACEI

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7
Q

Amlodipine (+Nifedipine)

A

Calcium antagonist of calcium entry blokkers
vasodilatatie, geen cardiale effecten
hypertensie bij kat

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8
Q

Diltiazem

A

Calcium antagonist of calcium entry blokkers
HCM

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9
Q

Verapamil

A

calcium antagonist of calcium entry blokkers
meest cardiaal potent
negatief inotroop
voor hypertensie
NOOIT bij hartinsufficiëntie en DCM

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10
Q

Propranolol en atenolol

A

beta blokkers
neg inotroop en chronotroop
hypertensie bij kat met hyperthryoïdie

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11
Q

anti-hypertensieve geneesmiddelen
(noem 4 groepen)

A

ACEI
Telmisartan
Calcium antagonisten
Beta blokkers

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12
Q

Anti-aritmica
(noem 4 groepen/medicijnen)

A

lokale anesthetica zoals lidocaïne
beta blokkers zoals propranolol
Ca antagonisten zoals Verapamil
Amiodarone

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13
Q

Vitamine K

A

hemostatica
leverinsufficiëntie, coumarine intoxicatie
vitamine K carboxyleert stollingsfactor -> actief

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14
Q

Etamsylaat

A

hemostaticum
remming prostcycline-synthese en activering P-selectine

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15
Q

Aspirine of acetylsalicylzuur

A

NSAID en antiaggregantia
cox-1 irreversibel inhiberen -> geen thromboxane A2 vorming
nadeel: spontane bloedingen

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16
Q

Clopidogrel

A

antiaggregantia
1ste keus thromboembolie
off label
P2Y antagonist -> verhindert actieve thrombocyten
prodrug

17
Q

Coumarines: Warfarine, Acenocoumarol en Dicoumarol

A

vitamine K antagonisten (anticoagulantia)
latentietijd
vitamine K reductase enzym inhibitie
hoge plasma eiwitbinding -> interactie andere gm

18
Q

Rivaroxaban (apixaban, edocaban)

A

directe orale anticoagulantia
factor Xa-inhibitoren

19
Q

Dabigatran

A

directe orale anticoagulantia
thrombine inhibitor (IIa)

20
Q

Enoxaparine, dalteparine, nadroparine

A

Heparines: LMWH
SC, lange T1/2e
inhibitie factor Xa door binden antithrombine III
diep veneuze thrombose, longembolie

21
Q

Danaparoïde

A

Heparines: heparinoïden
heparine induced thrombocytopenie door LMWH

Farmacologie (12 decks)

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