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Farmacologie > Antibiotica > Flashcards

Antibiotica Flashcards

1
Q

Werking Penicillines

A

inhiberen de transpeptidatie thv de peptidoglycaanlaag vd bacterie
bactericied, T>MIC

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2
Q

Penicilline G of Benzylpenicilline

A

Natuurlijk resistente penicillines

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3
Q

Penicilline V of Fenoxymethylpenicilline

A

Natuurlijke resistente penicillines

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4
Q

Cloxacilline

A

Beta lactamase resistente penicillines

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5
Q

Ampicilline

A

breedspectrum penicillines

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6
Q

Pivampicilline

A

breedspectrum penicillines

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7
Q

Amoxicilline

A

breedspectrum penicillines

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8
Q

Werking Cephalosporines

A

Inhiberen de transpeptidatie thv de peptidoglycaanlaag vd bacterie (~peni’s)
bactericied, T>MIC

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9
Q

Cefazolin

A

1ste gen Cephalosporines

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10
Q

Cefapirin

A

1ste gen Cephalosporines

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11
Q

Cefalexin

A

1ste gen Cephalosporines

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12
Q

Ceftiofur

A

3de gen Cephalosporines

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13
Q

Cefovecin

A

3de gen Cephalosporines

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14
Q

Cefoperazone

A

3de gen Cephalosporines

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15
Q

Cefixime

A

3de gen Cephalosporines

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16
Q

Cefquinome

A

4de gen Cephalosporines

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17
Q

Cefepime

A

4de gen Cephalosporines

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18
Q

Clavulaanzuur

A

beta-lactamase inhibitoren

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19
Q

werking beta-lactamasen inhibitoren

A

enkel beta lactamasen fysiek binden, soort resistentie tegengaan

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20
Q

Werking Macroliden

A

Inhiberen de proteïnesynthese: interferentie met translocatie van 50S
bacteriostatisch en T>MIC

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21
Q

Erythromycine

A

Macroliden

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22
Q

Spiramycine

A

Macroliden

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23
Q

Azithromycine

A

Macroliden

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24
Q

Clarithromycine

A

Macroliden

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25
Q

Tylosine

A

Macroliden

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26
Q

Tylvalosine

A

Macroliden

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27
Q

Tildipirosine

A

Macroliden

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28
Q

Tilmicosine

A

Macroliden

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29
Q

Tulathromycine

A

Macroliden

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30
Q

Gamithromycine

A

Macroliden

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31
Q

Werking Lincosamiden

A

Inhiberen de proteïnesynthese: interferentie met translocatie van 50S
bacteriostatisch en T>MIC (~Macroliden)

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32
Q

Lincomycine

A

Lincosamiden

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33
Q

Clindamycine

A

Lincosamiden

34
Q

Pirlimycine

A

Lincosamiden

35
Q

werking Pleuromutilins

A

Inhiberen van de proteïnesynthese (translocatie) door inhibitie peptidyltransferase enzym
bacteriostatisch en T>MIC

36
Q

Tiamuline

A

Pleuromutilins

37
Q

Valnemuline

A

Pleuromutilins

38
Q

werking rifamycines

A

Inhiberen RNA polymerase dus inhibitie van gentranscriptie naar mRNA
bactericies en T>MIC

39
Q

Rifampicine

A

Rifamycines

40
Q

Rifaximin

A

Rifamycines

41
Q

werking bacitracine

A

Blokkeert peptidoglycaansynthese (enkel tegen gram +)
bactericied en T>MIC

42
Q

Werking Aminoglycosiden

A

Ze zorgen voor wijziging van 30S subunit zodat verkeerde tRNA gebonden wordt en verkeerde AZ ingebouwd. ze werken via O2 afhankelijke passage dus anaeroon intrinsiek resistent

Bactericied en Concentratie afhankelijk Cmax/MIC

43
Q

Streptomycine

A

Aminoglycosiden

44
Q

Neomycine

A

Aminoglycosiden

45
Q

Gentamicine

A

Aminoglycosiden

46
Q

Amikacine

A

Aminoglycosiden

47
Q

Tobramycine

A

Aminoglycosiden

48
Q

Kanamycine

A

Aminoglycosiden

49
Q

Paromomycine

A

Aminoglycosiden

50
Q

Apramycine

A

Aminoglycosiden

51
Q

Werking Aminocyclitols

A

Ze zorgen voor wijziging van 30S subunit zodat verkeerde tRNA gebonden wordt en verkeerde AZ ingebouwd.

bacteriostatisch en concentratie afhankelijk

52
Q

Spectinomycine

A

Aminocyclitols

53
Q

werking polymyxines

A

werkt als kationische detergent en bindt op endotoxines

bactericied en concentratie afhankelijk

54
Q

Polymyxine E of colistine

A

Polymyxines

55
Q

Polymyxine B

A

Polymyxines

56
Q

Werking Fenicolen

A

Verhinderen de transpeptidatie

bacteriostatisch en T>MIC

57
Q

Florfenicol

A

Fenicolen

58
Q

Thiamphenicol

A

Fenicolen

59
Q

Chloramphenicol

A

Fenicolen

60
Q

werking tetracyclines

A

ze gaan fysiek in competitie met tRNA voor de A site waardoor tRNA niet met codon kan binden

Bacteriostatisch en concentratie afhankelijk

61
Q

Tetracycline

A

1ste gen tetracyclines

62
Q

Oxytetracycline

A

1ste gen tetracyclines

63
Q

Chlortetracycline

A

1ste gen tetracyclines

64
Q

Doxycycline

A

2de gen tetracyclines

65
Q

Werking sulfonamiden

A

Inhibitie van de opbouw van foliumzuur en dus inhibitie groei en deling bacterie

bacteriostatisch en T>MIC
bactericied als gepotentialiseerd

66
Q

Sulfasalazine

A

sulfonamiden
niet resorbeerbaar

67
Q

Sulfadiazine

A

sulfonamiden
middellangwerkende

68
Q

Sulfamethoxazole

A

sulfonamiden
middellangwerkende

69
Q

Sulfachlorpyrazine

A

sulfonamiden
anti-coccidiale

70
Q

werking Diaminopyrimidines

A

inhibeert de omzetting van dihydrofolaat naar tetrahydrofolaat dus inhibitie van foliumzuur

71
Q

Trimethoprim

A

Diaminopyrimidines

72
Q

Nitrofurantoïne

A

nitrofuranen

73
Q

werking Fluoroquinolonen

A

ze werken in op topoisomerase II (gram-) en topoisomerase IV (gram+) die verantwoordelijk zijn voor verwijderen van de supercoiling en ontkoppeling chromosomen voor verdeling dochtercellen. zo schade aan DNA

bactericied en concentratie afhankelijk

74
Q

Nalidixinezuur

A

1ste gen Fluoroquinolonen

75
Q

Flumequine

A

1ste gen Fluoroquinolonen

76
Q

Marbofloxacine

A

2de gen Fluoroquinolonen

77
Q

Danofloxacine

A

2de gen Fluoroquinolonen

78
Q

Enrofloxacine

A

2de gen Fluoroquinolonen

79
Q

Orbifloxacine

A

2de gen Fluoroquinolonen

80
Q

Pradofloxacine

A

3de gen Fluoroquinolonen

Farmacologie (12 decks)

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