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Farmacologie > Antimycotica > Flashcards

Antimycotica Flashcards

1
Q

Amfotericine B

A

systemische antimycotica
bindt rechtstreeks op ergosterol
fungicied

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2
Q

Ketoconazole

A

azole derivaat (antimycotica)
systemische mycosen
inhiberen synthese ergosterol door inhibitie schimmel CYP450

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3
Q

Clotrimazole

A

azole derivaat (antimycoticum)
topicaal als oordruppels
inhiberen synthese ergosterol door inhibitie schimmel CYP450

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4
Q

Enilconazole en miconazole

A

azole derivaat (antimycoticum)
topicaal huid
inhiberen synthese ergosterol door inhibitie schimmel CYP450

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5
Q

Fluconazole, Voriconazole, itraconazole, posaconazole

A

azole derivaat (triazoles: antimycotica)
100x actiever dan imidazoles
langere halfwaardetijd
selectiever

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6
Q

Terbinafine

A

antimycotica
inhiberen squaleen epoxidase -> inhiberen ergosterol synthese
fungistatisch
oraal/topicaal

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7
Q

Flucytosine

A

antimycotica
pyrimidine antagonist

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8
Q

Griseofulvine

A

antimycotica
werkt in op microtubuli
niet meer gebruikt

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9
Q

Nyastatine en natamycine

A

topicale antimycotica
te toxisch voor systemisch

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Farmacologie (12 decks)

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