Cardiology Flashcards
What are the atria and ventricles separated by?
Annulus fibrosus
Normally, the heart occupies ???% of the trans-thoracic diameter
<50%
Which structure form the cardiac silhouette?
Aortic arch Pulmonary trunk Left atrial appendage Left ventricle Right atrium SVC and IVC Right ventricle
What is the most common cause of angina and acute coronary syndrome, and the most common cause of death worldwide?
Coronary artery disease
What is coronary artery disease usually caused by?
Atherosclerosis
List 3 causes of coronary artery disease, other than atherosclerosis
- Vasculitis
- Aortitis
- Autoimmune connective tissue disease
List the features of an unstable atherosclerotic plaque
Lipid-rich core Fibrocellular cap Speckled calcification Increased inflammatory cells Few crosslinks
List the risk factors for atherosclerosis
Age Male Family history of early-onset coronary artery disease Smoking Familial hyperlipidaemia Hypertension T2DM Platelet activation/high plasma fibrinogen Antiphospholipid antibodies Inactivity Obesity/high fat diet Alcohol Social deprivation
Describe the classification system for atherosclerosis
Type 1 - isolated macrophage foam cells
Type 2 - ‘fatty streak’ of intracellular lipid accumulation
Type 3 - type II changes + small extracellular lipid pools
Type 4 - Atheroma
Type 5 - Fibroatheroma (lipid core with fibrotic layer, or multiple lipid cores with fibrotic layers
Type 6 - complicated fibroatheroma e.g. surface defect, haematoma, haemorrhage, thrombus
What lifestyle advice would you give to help prevent atherosclerosis?
Quit smoking
Take regular exercise (20 mins 3x weekly)
Maintain a healthy body weight
Eat a mixed diet rich in fresh fruit and vegetables
Aim to get no more than 10% of energy from saturated fats
What two conditions are considered acute coronary syndromes?
Unstable angina
Myocardial infarction
Define unstable angina
New-onset or rapidly worsening angina (crescendo angina), angina on minimal exertion or angina at rest in the ABSENCE of myocardial damage
Define myocardial infarction
Angina with evidence of myocardial necrosis
What is the most common cause of acute coronary syndromes?
Atherosclerosis
Describe the typical clinical features of acute coronary syndrome
Severe, long-lasting tight/heavy/constricting chest pain at rest Radiation of pain to neck/arms/epigastrium/back Anxiety/distress Breathlessness Nausea/vomiting Collapse/syncope Pallor Sweating Changes in heart rate Hypotension Cold peripheries Oliguria
Which patients are more likely to experience a ‘silent’ MI?
Older patients
Diabetics
What investigations would you perform in a patient presenting with chest pain?
- History & examination
- 12-lead ECG
- Serum Troponin I or T
- Repeat ECG & Troponin (6-12 hours after presentation)
Describe the changes typically seen in an ECG of a patient with a STEMI?
- Hyperacute T waves
- ST elevation
- Progressive loss of R waves
- T wave inversion
- Q wave development
What ECG pattern would make you think a patient had an old or established infarct?
Presence of Q waves and T wave inversion
Describe the changes typically seen in an ECG of a patient with an NSTEMI?
ST depression and T-wave changes
Describe the typical pathology of an non-ST acute coronary syndrome
Partial occlusion of a major vessel OR
Complete occlusion of a minor vessel
ECG changes in leads V1-6 and aVL would indicate ischaemia in which region?
Anterior heart
ECG changes in leads V1-4 would indicate ischaemic in which region?
Anteroseptal
ECG changes in leads V4-6 and aVL would indicate ischaemia in which region?
Anterolateral