Cardiology Flashcards
MOA of Thiazide Diuretics
Inhibit reabsorption of sodium and chloride ions in the distal tubules
Contraindications to Thiazide Diuretics
Gout
Hypotension
Hypothermia
Renal failure
Lithium tx
Sensitivity to sulfa drugs
MOA of loop diuretics
Inhibit the sodium- potassium-chloride pump of the kidney in the loop of Henle
Contraindications to Loop Diuretics
Anuria (kidney failure)
MOA of Aldosterone Receptor Antagonist Diuretics/Mineralocorticoid receptor antagonist/Antimineralcorticoids
Antagonizes the action of aldosterone. Increases elimination of water in the kidneys and conserves potassium
Increases risk of hyperkalemia
ACEIs
ARBs
NSAIDs
Side effect of Spironolactone
Gynecomastia
Usually reversible after DC
Beneficial side effect of Thiazide Diuretics
Help bone loss by slowing down calcium loss (from the bone) and stimulating osteoclasts
MOA of BB
Decreases vasomotor activity, decreases CO, and inhibits renin (kidney) and norepinephrine release
CI of BB
Asthma, COPD, chronic bronchitis, emphysema
Second and third degree heart block (okay to use with first degree)
Types of beta receptors
Beta 1: cardiac
Beta 2: lungs, vascular smooth muscle
Cardioselective BB
Atenolol
Metoprolol
Bisoprolol
MOA of CCB
Block voltage gated calcium channels in cardiac smooth muscle. Results in systemic vasodilation.
SE of dihydropyridine CCBs
HA (d/t vasodilation)
Flushing
Ankle edema (vaso and benign) - dose dependent
Heart block (depressed cardiac muscle and AV node)
Reflex tachy
CI to CCB
Sick sinus syndrome
Second and third degree heart block
Brady
HFrEF
Dihydropyridine CCBs
-pine ending
Nifedipine
Amlodipine
Felodipine
Non-dihydropyridine CCBs
Verapamil
Diltiazem
MOA of ACEIs
Inhibit activity of angiotensin-converting enzyme, which decreases conversion of angiotensin I to II (more potent vasoconstrictor)
MOA of ARBs
Block the effect of angiotensin II