Cardiology Flashcards
what should be paid close attention for in diabetes with non specific symptoms and no chest pain present?
silent MI
if angina is not controlled with a beta blocker what should be added?
CCB
how does myocarditis present in a young patient?
ST elevation
acute pulmonary oedema
flu like symptoms
what is the NSTEMI management in unstable patients?
immediate coronary angiography
what should be investigated for in a patient with new BP >180/120 and no worrying signs
urgent investigation for end-organ damage
what can pericarditis arrise secondary to?
malignancy
what should be added to a patient with poorly controlled hypertension already on a CCB?
add ACEi or ARB or thiazide-like diuretic
what can happen after infarction of a right coronary and why?
can cause arrhythmias due to supply of the AV node
what are the most common ECG findings in arrhythmogenic right ventricular dysplasia? (ARVD)
epsilon wave
what is an epsilon wave?
small positive deflection at the end of QRS complex
what cardiology disease may patients with poor dental hygiene present with?
endocarditis secondary to streptococci infection
how do diuretics help heart failure?
only improve symptoms
no effect on mortality
what disease may thiazides cause?
gout
what diseases is Mitral regurgitation associated with?
collagen disorders such as Marfan’s syndrome and Ehlers-Danlos syndrome
what is S3 (gallop rhythm) a sign of?
LVF
what should be done in a suspected PE with wells score <4 and D-dimer is negative
stop anticoagulation
consider alternative diagnosis
what is the gold standard treatment for patient with STEMI
primary percutaneous coronary intervention
in heart failure with a reduced EF and maintained symptoms what should be offered after a ACEi and Beta blocker
mineralocorticoid receptor antagonist
what is aortic regurgitation associated with?
Marfan’s syndrome
what electrolyte imbalance may thiazide diuretics cause?
hypokalaemia
what is the investigation for suspected aortic dissection?
CT angiography
what should be done in new onset AF <48hrs after presentation?
electrical cardioversion
how long is the treatment for unprovoked PE?
6 months
what is the investigation for suspected PE with wells score >4
D-dimer
what is the conservative management for an NSTEMI antiplatelet choice?
aspririn plus either
ticagrelor (not high bleeding risk)
clopidogrel (high bleeding risk)
what may orthostatic hypertension be exacerbated by?
venous pooling during exercise
post prandial
post prolonged bed rest (deconditioning)
what disease is associated with sudden cardiac disease in young athletes?
hypertrophic obstructive cardiomyopathy
how long are provoked PE treated for?
3 months
what can cause long QT syndrome?
hypokalaemia
antidepressants (SSRI and tricyclics)
what is stable angina?
chest pain on exertion that is relieved by rest
what is the management for stable angina?
beta blockers
GTN spray
risk factor modification
what is the cause of stable angina?
mismatch in oxygen supply and demand to myocardium
what test should be run in non-ST elevation chest pain?
troponin
what is the cause of Non-ST elevation on ECG with high troponins?
NSTEMI
what is the cause of non-ST elevation on ECG with normal troponins?
Unstable angina pectoris
what are the ECG findings in an NSTEMI?
dynamic T wave inversion
ST depression
what can T wave inversion with sudden chest pain be suggestive of?
myocardial ischaemia
what is the immediate and long term management of ACS?
MONA BASH morphine oxygen nitrates- GTN spray antiplatelet- dual- aspirin and clopidogrel or ticagrelor
Beta blockers (bisoprolol)
ACEi (ramipril)
Statin (atorvastatin)
heparin
what is the management of a STEMI <12 hrs from symptoms
percutaneous coronary intervention if possible within 2 hours or thrombolysis if not within 2 hours
what is the management STEMI >12 hrs symptoms?
angiography followed by PCI if necessary
what is the management of NSTEMI?
- immediate ACS protocol
- fondaparinux
- risk stratify high or low
what is the treatment for high risk stratified NSTEMI?
angiography within 48-72 hours
what is the treatment for low risk stratified NSTEMI?
medical management
what are the signs of right heart failure backlog in veins?
peripheral oedema
what are the signs of left heart failure
pulmonary oedema - breathlessness, cant lie flat, wake at night breathless
what are the causes of heart failure?
valvular disease
cardiomyopathy
hypertenion
IHD
what are the bedside tests for heart failure?
ECG
what are the bloods for heart falure?
ABG
troponin
BNP
what is BNP released in response to?
ventricular stretch
what imaging can be done for heart failure?
CXR- pulmonary oedema
echo
what is the immediate management for heart failure?
sit the patient up
high flow oxygen (15L/min via non-rebreathe mask)
what is the medical management for heart failure?
IV furosemide (loop diuretic)
GTN or isosorbide mononitrate
morphine
what is the long term management for HF?
beta blocker (bisoprolol)
ACEi( ramipril)
risk factor modificaiton
what are the signs of pulmonary oedema on CXR?
alveolar shadowing kerly B lines cardiomegaly upper lobe diversion PE
what are the causes of AF?
idiopathic pneumonia IHD valvular disease hyperthyroidism alcohol PE
what is the ECG signs of AF?
irregularly irregular narrow complex tachycardia with no p-waves
what is the management of hemodynamically unstable AF?
DC cardioversion
what can be used for rate control in AF?
beta blocker (bisoprolol)
what is used for rhythm control in AF
when clear reversible cause <48hrs –> DC or chemical cardioversion
>48hrs –> anticoagulated 3-4 weeks first
what drugs can be used for chemical cardioversion?
amiodarone
flecainide
what score can be used to calculate stroke risk after AF?
CHADS-Vasc
what score is used for risk of bleeding if anticoagulated?
HAS-BLED
what is used to minimise stroke risk after AF
DOAC (apixaban)
after calculating CHADS-Vasc vs HAS-BLED
what is virchow’s triad?
factors contributing to abnormal clot formation
Stasis
hypercoagulability
vessel wall injury
what may cause stasis?
activation of clotting factors from
AF or venous clots (PE/DVT))
what pathway do anticoagulants act on
Stasis
inactivation of clotting factors
what does vessel wall injury result in?
platelet activation resulting in a clot formation
what may vessel wall injury cause?
arterial thrombosis (MI, stroke)
what do anti-platelets work on?
inhibit platelet activation after vessel wall injury
what is SVT?
regular narrow complex tachycardia with no P-waves and supraventricular origin
what electrical abnormalities can cause SVT?
AVNRT
AVRT
what causes AVNRT
nodal circuit formed within AV node that randomly fires off causing ventricular depolarisation
what causes AVRT
accessory pathway between atria and ventricles
what ECG abnormality may be present after the termination of the SVT?
delta wave (slurred upstroke of QRS complex)
what disease may have the presence of an accessory pathway that pre-disposes to SVT?
WPW syndrome
what is the management for haemodynamically unstable SVT?
DC cardioversion
what is the management for haemodynamically stable SVT?
- vagal manoeuvres
- if unsuccessful- Adenosine 6mg
- If unsuccessful- adenosine 12mg
- if unsuccessful - adenosine 12mg again
- if unsuccessful again Beta blockers, IV digoxin, IV amiodarone, synchronised DC cardioversion
what drug used in SVT is contraindicated in asthma? and what should be used instead?
adenosine - use verapamil
what type of murmur is aortic stenosis?
ejection systolic
what type of murmur is mitral stenosis
mid diastolic
what type of murmur is aortic regurgitation?
early diastolic
what type of murmur is mitral regurgitation?
pan systolic
what are the right sided murmurs?
tricuspid and pulmonary
when are right sided murmurs heard loudest?
inspiration
as blood goes IN the right side
what are the left sided murmurs
mitral and aortic
when are left sided murmurs heard loudest?
Expiration
as blood EXits the left side of the heart
what are the causes of murmus?
infective endocarditis senile calcification (especially aortic valve) rheumatic heart disease cardiomyopathy physiological (high turbulent flow) ischaemic heart disease
what side heart murmurs are more common and why?
left- higher pressure system
what are right sided heart murmurs commonly caused by?
IV drug users by S. aureus infection
what is acute limb ischaemia?
sudden decrease in limb perfusion that threatens the viability of the limb
what is a major risk factor for acute limb ischaemia?
AF
what is the presentation of acute limb ischaemia?
6P's pale pulseless painful perishingly cold paralysis paraestheia
what is the management for acute limb ischemia?
IV heparin immediately
refer vascular surgery
options: embolectomy, bypass, amputation
what is peripheral vascular disease?
limb ischaemia resulting from atherosclerosis in the lower limb vasculature
what is the presentation of mild peripheral vascular disease?
intermittent claudication
what is intermittent claudication
cramping leg pain after walking
relieved by rest
peripheral parallel of stable angina
what are the signs of a severe form of PVD?
ulcers (tissue loss)
gangrene
limb pain at rest
night pain
what are the investigations for PVD?
ABPI (ankle brachial pressure index)
duplex USS
CT/MRI angiography
dealt with by vascular surgeons
what should be given before angiography?
IV unfractionated heparin
what are stents infused with for anti-proliferative agent?
tacrolimus
what are the consequences of tacrolimus for anti-proliferation in stents?
decreased endothelialisation requiring Dual antiplatelet therapy for 1 year, after which can continue on one antiplatelet
what can cause a raised BNP?
heart failure
left ventricular dysfunction (MI or valvular disease)
chronic kidney disease
what factors reduce BNP levels
ACEi
ARB
diuretics
when should antihypertensive treatment initially be offered
<80YO stage 1 hypertension with organ damage, established CVD, diabetes, renal disease and >10% QRISK
stage 2 hypertension always
what is the diagnosis of stage 1 hypertension?
BP >140/90 clinically
ABPM >135/85
what is diagnosis of stage 2 hypertension
BP >160/100 clinically
ABPM >150/95
what is diagnosis severe hypertension
clinical systolic >180 or diastolic >110
what is the first line treatment for hypertension?
<55 or diabetic ACEi or ARB
>55 of black african/acro-caribbean = CCB
what are the ECG findings suggestive of cardiac tamponade?
electrical alternans (varying heights of QFS complex)
what is used to counteract warfarin
vitamin K
what should be done in a patient with INR > 5 <8 with minor bleeding
withold warfarin until INR <5
give vitamin K
what should be done in a patient >8 no bleeding
stop warfarin
give vitamin K
restart when INR <5
what should be done in patient with 5
withold couple doses warfarin
no vit K
if angina is not being controlled with a beta blocker what should be added?
CCB (amlodipine)
what are the signs of VSD?
symptoms of heart failure
pansystolic murmum at lower left sternal edge (blood rushing across septum from left to right ventricle)
louder P2
what is the most common cause of mitral stenosis?
rheumatic fever
what is used to treat torsades de pointes?
IV magnesium sulfate
what are a side effect of thiazide diuretics?
hypercalcaemia and hypocalciuria
what is the likely diagnosis in a patient with persistent ST elevation 4 weeks post MI with bibasal crackles and S3 and S4 heard
left ventricular aneurysm
what should be given to paitents with >10% CVD risk?
statins
for black african or african-caribbean origin taking a CCB for hypertension what is the preferred second agent if required?
ARB over ACEi
what is used to treat symptomatic bradycardia first line?
atropine
what is used to treat symptomatic bradycardia if atropine fails?
external pacing
what is the likely diagnosis of a young male smoker with symptoms similar to limb ischaemia?
Buerger’s disease
what drug may be associated with visual disturbances including phosphenes and green luminsecence?
ivabradine
what do statins commonly have interaction with?
clarithromycin/erythromycin