Cardio NM Flashcards
Appropriateness criteria
Chest pain
Anginal equivalent - - dyspnea, worsening effort tolerance
No symptoms - - risk for cardiovascular events
Low–age-specific risk below average, 10 year abs risk for CHD <10%
Moderate - - average or above average, 10-20%
High - - >20%
MPI appropriate
Intermediate and high pretest probability of CAD (>11%)
To exclude CAD
Exercise ECG not possible
Abnormal baseline ECG
At least one risk factor prior to high risk surgery
Agatston score for coronary calcium
<100 - - MPI inappropriate
>400 - - MPI appropriate
3 months after ACS
MPI not indicated unless no prior angiogram
MPI patient preparation
Fast 4h
No coffeine 12h
Check sugar before stress if DM
Avoid heavy meal
Hemodynamically stable 48h
Stop for 3 T1/2 - nitrates, beta blockers, anti calcium - - reduce incidence of ischemia
Stop for 5 T1/2 methylxanthine
MPI for assessment ischemia and therapy effectiveness
Continue cardiac medications
MPI pregnancy
Fetal absorbed dose higher in early stages
2 day protocol
Stress first
Lactating - - no
Stressor exercise
First choice if suspected or known CAD
Goal - to reach 85% of predicted max (220-age)
Continous monitor
Bicycle - - quadriceps fatigue - - stop before
Not if: lung, peripheral vascular, musculoskeletal, neuro disease, poor motivation
Rate pressure
Heart rate * systolic BP = double product = METS
>25000 mmHg/min - - good level of exercise
>30000 mmHg/min - - excellent level
Reasons to fail exercise
Low tolerance
Poor motivation
Arthritis
Lung disease
Peripheral vascular disease
Beta blockers
Angina
Arrhythmia
Cardiac insufficiency
Stress test injection
Tracer injected close to peak exercise - - continue exercise for 1-2 min
Vasodilators mechanism
Induce myocardial hyperemia by Adenosine receptors independent of myocardial oxygen demand
Indication: inability to exercise and LBBB
Consider if ACS and unstable Angina stable for 48h
Regadenoson and COPD
can be used if not actively wheezing.
If severe COPD - - inhaled bronchodilator prior to tracer admin
Vasodilators Combi with low level exercise
Reduce flashing, dizziness, nausea, headache, hypotension
Reduce bowel activity - - better image quality and target-to-background ratio
Not for LBBB and pacemaker
Adenosine
direct coronary arteriolar vasodilation through A2a receptor
3.5-4 fold increase myocardial blood flow
Peak vasodilation 1-2 min after start, T1/2 10 sec
Adenosine injection
Infusion or syringe pump
2 separate IV lines or 1 line with dual port Y connector
Continuous infusion 4-6 min
1 min 50 microg/kg/min - - 75, 100, 140 at 1 min interval
Tracer after 140 microg/kg/min at 2-3 min, infusion continue for 2-3 min
Adenosine side effects
Minor side effects 80%
Flushing 35-40%
AV block 8% self limiting
ST depression >1 mm5-7% - - true ischemia
AFib within several min
Convulsive seizures
Cerebrovascular accidents
Adenosine
Patient preparation
Fast 4h
No coffeine 12h
Nitrates, beta blockers, anti Calcium stop
Regadenoson
Agonist of A2a receptor
10 fold lower A1
Weak A2b and A3
Max plasma concentration 1-4 min
Manual injection, large catheter
0.4 mg regardless of weight in 5 ml
Slow bolus 30s
10s flush 5-10 ml saline
Tracer within 2 min
Side effects: shortness of breath, headache, flushing
rhythm abnormality 26%, headache 29% resolves in 30 min
No problem with bronchospasm
Regadenoson + Aminophylline
50-250 mg slow IV over 30-60 sec at least 1 min after tracer
Indication:
Systolic BP <80
Symptomatic persistent AV block
Other Arrhythmia
Wheezing
ST depression >2 mm + chest pain
Pallor, cyanosis, cold skin
Dipirydamole
Indirect vasodilator - - prevents reuptake and deamination of adenosine - - 3.8-7 fold increase blood flow - - hyperemia for 50 min
Peak vasodilation on 6.5 min
T1/2 30-45 min
Excrete in bile
Infusion pump or manual injection
Continuous IV 0.56 mg/kg/min over 4 min
Tracer 3-5 min after
Dipirydamole
Side effects
Chest pain > AV block > ST changes
Aminophylline at least 3 min after tracer (not in seizure)
Dobutamine
Sympathomimetic
Beta1 and beta 2 stimulation
Increase oxygen demand - - increase regional blood flow
Infusion pump, 2 separate IV or 1 with Y-connector
Start at dose 5-10 microg/kg/min
3-5 min interval 20, 30, 40 microg/kg/min
Tracer when HR >85% of predicted
Continue for 2 min after tracer
Fast 3h
Stop nitrates, beta blockers, anti Calcium
Atropine
May add atropine 0.25 mg IV to dobutamine if HR doesn’t reach 85%
Possible difficulties driving in 2h after atropine due to reduced ocular accommodation
Contra: narrow angle glaucoma, obstructive uropathy (incl bladder neck obstruction by BPH), AFib with uncontrolled HR, obstructive GI disease or paralytic ileus
Dobutamine side effects
Ischemic ST depression in 1/3 patients
Severe - - IV esmolol 0.5 mg/kg over 1 min or metoprolol 5 mg
Palpitation > Significant SVT or VT
Dobutamine indication
Only patients who can not undergo exercise stress and have contraindication to vasodilator (bronchospasm)
Thallium 201
Analog of K - - Na/K ATPase pump - - cytosol
No K in scar
T1/2 73.1h
Cyclotron
Electron capture
68-82 keV X-ray 88%
135 and 167 keV gamma 12%
First pass extraction 85%
Cardiac uptake 3%
Thallium dose
74-111 MBq prior to peak exercise or at peak pharm vasodilation
SPECT 10-15 min later
Redistribution (rest) 2.5-4.0h later
Reinjection 37 MBq or rest at 18-24h
Thallium uptake
Proportional to perfusion
Prolonged retention depends on viability
Uptake in lung - - lung/heart ratio >45 - - severe and multivessel CAD
Thallium redistribution
Nonuniform clearance from myocardium
Slower clearance from areas of ischemia and more rapid from areas with normal perfusion
Occurs over several hours after administration
Thallium limitations
Long T1/2 - - high radiation burden to kidneys
Low injected activity - - suboptimal in obese
Low energy emission - - significant scatter and attenuation by soft tissue - - low resolution
Tc Sestamibi vs tetrofosmin
Lipophilic cation
Retain in intact Mitochondria - - viable myocytes
T1/2 6h
On site labeling
Isomeric transition - - 140 keV - - ideal for gamma camera
First pass extraction 60%
Cardiac uptake 1.5% vs 1.2%
Excretion biliary 80% vs biliary 50%, renal 50%
Protocols
Two day
350-700 MBq/study
>113 kg or BMI >35 or big breast - - 666-1110 MBq each day
One day
250-400 MBq (1/4 of total activity) first injection
3/4 of total activity second injection
3:1 ratio of activities + 2h delay = 4:1 ration no delay
Early post exercise image - - increase detection of post ischemic wall motion impairment
MPI timing
Tc advantage
Higher energy - - less attenuation and scatter - - better quality images
Shorter half life - - higher activities - - better counting statistics
Tc disadvantage
Splanchnic uptake and excretion higher than Tl - - worse interpretation of inferior wall
Tracer molecules remain within myocytes - - 2 days for optimal stress and rest images
Uptake is less avid than Tl
Radiation exposure to staff is higher
Myocardial stunning
Persistent LV contractile dysfunction despite restoration of perfusion
Resolve within 30 min
Normal perfusion, poor contraction
FDG uptake
Gating
R-wave has to be positive and at least 3 fold higher that other positive waves
Heartbeat is divided into 16 temporal frames and bins
Exercise induced ischemia
ST depression
MPI rrhytm abnormalities
Arrhythmia - - acquisition times prolonged, loss of accuracy
Regular brady/tachy - - influence LVEF and volume values
Number of rejected beats limited to <25%
Beat length acceptance window 20%
Irregularly Irregular rhythm - - no gating
Short axis
Horizontal long axis
Vertical long axis = sagittal
Myocardial ischemia
Hypoperfusion (cold defect) on stress
Myocardial infarction
Hypoperfusion on rest-stress perfusion and decreased uptake with metabolic imaging
Transmural infarction
All layers necrosis
High sensitivity MPI
Subendocardial infarction
Only muscle adjacent to endocardium
Lower sensitivity MPI
Myocardial scar
Hypoperfusion stress and rest