Cardio: Antihyperlipidemic Drugs Flashcards
What are the PCSK9 Inhibitors?
O-Cum Antibodies
What are the First drugs of choice to reduce blood-lipid levels? In what order to you give them?
- Statins
-
Least potent first then go down the line
- Simvastatin is least potent so you start them there.
- Pravastatin is MOST potent.
What are the fibrates?
How do fibrates work? (MOA)
What are they used for?
What are the lipid effects of Niacin?
Which statins are metabolized by CYP450, 2C9?
fluvastatin
What are the Lipid effects of statins?
What is Niacin used for?
For PCSK9 Inhibitors, list the
- Lipid Effects
- PKs
- ADRs
What are the Bile-Acid Sequestrants (BAS)?
What are the ADRs and DDIs for Bile-Acid Sequestrants (BAS)? What do you need to monitor because of the ADRs and DDIs?
Need to stagger doses throughout the day of other oral drugs because of DDIs
What are the PCSK9 Inhibitors ?
O-Cum antibodies
How Bile-Acid Sequestrants (BAS) work?
What condition are they especially food for?
- They force bile salts into the excretory pathway. The liver uses cholesterol to make bile salts, so these drugs decrease LDL by increasing cholesterol conversion into bile salts
Statins have Extensive first-pass metabolism. How do you get around this?
Prodrugs (Simvastatin and Lovastatin)
What is the MOA for statins?
- For Omacor
- What are its components?
- What are its effects on lipids?
- When do you use it?
- What its PKs?
What are they DDIs for fibrates?
What is the channel that Ezetimibe actually blocks?
What are the Bile-Acid Sequestrants drugs?
COLE-
- What are the ADRs subsequent monitoring parameters for Niacin?
- What conditions are contraindicated for Niacine use?
?Which statins are metabolized by CYP450, 3A4?
SAL
Why do you give some statins at night? What are the statins that this is important to remember?
What are the statins we need to remember?
My sim got the flu, so I gave them love and roses.
What are the Fibrates?
A feminine gemini
How do PCSK9 Inhibitors work?
How does Niacin work, and what are the PKs for it? When do you use niacin for hyperlipidemia?
Decrease of hormone-sensitive lipase in adipose tissue
For Ezetimibe, what is the MOA and what are the lipid effects?
What are the components of Omega-3 Fatty Acids?
What is the name of OTC drug?
What are the ADRs for statins?
What is Ezetimibe used for, and what is are its DDIs/ADRs?
For fibrates,
- What are the Laboratory test reactions?
- What are the ADRs?
- What are the Monitoring Parameters?
How do you take Bile-Acid Sequestrants (BAS) and what are the lipid effects? What drugs do they have synergistic effects with?
