Cardio: Alpha/Beta Receptor Agonists

Question 1

• The left column is tissues and the right column is the effects of receptor activation on that tissue.
  
  • What receptor is associated with these tissues and effects?

Answer 1

β1

Question 2

What is the receptor selectivity and general effects of Norepinephrine?

What is the clinical application for it?

Answer 2

Question 3

What are the clinical applications for non-selective β agonists?

Answer 3

Question 4

What are the general effects of α2 agonists?

Answer 4

Question 5

What are the general clinical applications for catecholamines?

Answer 5

Question 6

What are the general Clinical Applications for α2 Agonists?

Answer 6

• Stimulating α2 Receptors Inhibits Sympathetic Nervous System Tone
  
  • Treatment of hypertension

Question 7

What is the receptor selectivity and general effects of Dopamine?

Answer 7

Question 8

What is ⍺-Methyldopa?

Answer 8

α2 Selective Agonist

(Prodrug, decarboxylated to a-methylnorepinephrine)

Question 9

What are the sympathetic receptor agonist mnemonics?

Answer 9

METH and OXY increase DOPAmine, DOUBle time. Insane

• Methoxyamine: α1 selective agonist
• ⍺-Methyldopa: α2 selective agonist
• Dobutamine: β1 selective agonists
• Isoproterenol: Nonselective β agonists

AL MET SAL at the winTER FORMal

*

Question 10

What are the general effects and clinical applications of β2 selective agonists?

Answer 10

Question 11

What are the Receptor Selectivity and general effects of Epinephrine?

Answer 11

Question 12

What kind of drug is Dobutamine?

Answer 12

β1 selective agonist

Question 13

What are the β2 selective Agonist drugs?

Answer 13

AL MET SAL at the winTER FORMal

(last two last the longest [>12 hrs])

Question 14

What kind of drug is Isoproterenol?

Answer 14

β1 and β2 agonist (non-selective β agonist)

Question 15

Describe the catecholamine selectivity

• Norepinephrine
• Epinephrine
• Dopamine

Answer 15

Question 16

What are the general effects of ⍺-Methyldopa?

Answer 16

Question 17

• The left column is tissues and the right column is the effects of receptor activation on that tissue.
  
  • What receptor is associated with these tissues and effects?

Answer 17

α1

Question 18

What are the clinical applications and ADRs for Dobutamine?

Answer 18

Question 19

What are the clinical applications and ADRs for Isoproterenol?

Answer 19

Question 20

The left column is tissues and the right column is the effects of receptor activation on that tissue.

• What receptor is associated with these tissues and effects?

Answer 20

β2

Question 21

What are the general ADRs for Catecholamines?

Answer 21

Question 22

What is Methoxyamine used to treat and what are its ADRs?

Answer 22

Question 23

What are the effects of Isoproterenol?

Answer 23

Question 24

What are the cardiac clinical applications for dopamine?

Answer 24

Treatment of shock caused by low cardiac output and renal failure

Question 25

What are the Clinical Applications for α1 Agonists?

Answer 25

Question 26

The left column is tissues and the right column is the effects of receptor activation on that tissue.

• What receptor is associated with these tissues and effects?

Answer 26

α2

Question 27

What kind of drug is Methoxyamine?

Answer 27

α1 Agonist

Question 28

What are the general effects of β1 agonists?

Answer 28

Question 29

What are the clinical applications and ADRs for ⍺-Methyldopa?

Answer 29

Question 30

What receptor is considered an autoreceptor?

Answer 30

α2

Question 31

What are the clinical applications for Epinephrine?

Answer 31

• Asthma (β2)
• Anaphylaxis (β2, β1, α1)

Question 32

What are the general clinical applications of β1 agonists?

Answer 32

• Stimulating Sympathetic Nervous System β1 Receptors
  
  • Treatment of heart failure and cardiogenic shock

Question 33

What are the general effects of α1 Agonists?

Answer 33

Question 34

What are the effects of Dobutamine?

Answer 34