Cardio Flashcards
Diamond classification
substernal or L sided chest pain
worsened w/ exertion
relieved with NTG and rest
Typical angina
3/3 of diamond classification
Atypical angina
2/3 of diamond classification
Non-anginal
0-1 of diamond classification
Diagnostic studies for angina
R/O STEMI first β 12 lead EKG
If STEMI β π¨ cath lab
If NO STEMI β troponins
If β trop β π¨cath
If no ST elev or β trop β stress testβ if β electively go to cath
Eval stress test with:
EKG β if nl baseline EKGβ β if ST Ξ
Echo β baseline EKG abnl β β if no mvt
Nuclear β prev coronary artery bypass
Clinical intervention for angina
Cath β
if β₯3 vessels β CABG
if 1-2 vessels β stent
Clin therapeutics angina
Morphine
Oβ β NC
Nitrates β if CAD + angina
*Aspirn β 1st
*Ξ²-blocker β next after aspirin
*ACE-I
*Statin
Heparin β if high sus of CAD
Clopidogrel β if stent
tPA if in rural setting and canβt get to cardiologist within 60 min
*everyone gets
What med β mortality when used to control CP
morphine
Stable Angina
Substernal chest pain w/ exertion and relieved w/ rest and NTG
β
Biomarkers
β
ST Ξ
β Stress test
Stable Angina tx
Med mgmt only
Unstable Angina
90% occlusion
demand ischemia
Chest pain at rest & nothing relieves pain
β
Biomarkers
β
ST Ξ
UA treatment
Hosp admission & cath + meds
If not treated will progress to STEMI
NSTEMI
Heart is damaged β 90% occlusion
demand ischemia
CP at rest
β troponin
β
ST elevation
NSTEMI tx
Hosp admission & cath + meds
When should you AVOID giving nitrates when a pt has chest pain
II, III, avF (inferior) ST elevations β RV infatcton β NO NITRATES bc RV is preload dependent and will cause severe hypotension
A fib mgmt
Stableβ rate control
Ξ² blockers (Metoprolol), CCB (Diltiazem, Verapamil), Digoxin preferred for rate control in pts w/ hypotension or CHF
Unstable β synchronized cardioversion
need to anticoag if >48h
Anticoagulation
NOACs β Dabigatran, Rivaroxaban, Apixaban, Edoxaban
Warfarin-Preferred if severe CKD, HIV on PI, CYP450 antiepileptics (carbamazepine, phenytoin)
INR goal of 2-3
Aspirin + Clopidogrel (not as good)
Torsades mgmt
defib + IV magnesium
V tach mgmt
If stable β Amiodarone 150 mg IV over 10 min; repeat as needed to maximum dose of 2.2 g in 24 hours
Unstable β defibrillate
If pulseless β CPR q 2 min, defib and alt epi and amio alt q 2 min
Med mgmt of sinus brady
Unstable β pace
Atropine
Mgmt of 2nd deg heart block
Atropine or temporary pacing
If you give atropine it may push into 3rd deg and worsen
Progression to 3rd deg common so pacing is definitive tx*
PEA/asystole mgmt
CPR q 2 min with epi q 4 min
NO shock
What is CHADSVASC
CHF Hypertension Age ( β₯ 65 = 1 point, β₯ 75 = 2 points) Diabetes Stroke/TIA (2 points)
VASc β peripheral arterial disease, previous MI, aortic atheroma, female gender
Duke criteria for endocarditis
pt must have 2 major OR 1 major and 3 minor OR 5 minor
Major: 2 pos blood cx, ECHO evidence of endo involv or regurg
Minor: predisposing factor, fever >100.4, vascular phenomena (embolic dz, pulm infect), immunologic phenomena (glomerulopnephirtis, osler nodes, roth spots)
Dilated Cardiomyopathy pathophys
β₯ chambers dilate β floppy + thin walls
β contractility
Dilated Cardiomyopathy sx
Sx typical of systolic CHF β orthopnea, PND, DOE, crackles, peripheral edema
Dilated Cardiomyopathy dx
Echo β dilated chambers
Dilated Cardiomyopathy tx
β EtOH, β chemo
Transplant
Goal: target CHF sx
Ξ²-blocker
ACE-I
Diuretics β furosemide
Hypertrophic Obstructive Cardiomyopathy pathophys
Unilateral septum hypertrophy β covers aortic opening β LV outlet obstruction
Hypertrophic Obstructive Cardiomyopathy sx
Young athlete*
Aortic stenosis murmur
DOE, syncope w/ exertion, sudden cardiac death
Systolic, heard best at 2nd ICS RSB (base), crescendo-decrescendo
Hypertrophic Obstructive Cardiomyopathy tx
Avoid dehydration β do not get HR up, AVOID exercise
EtOH ablation, myectomy, AICD if at β risk of death
Definitive tx β transplant
Goal: keep ventricle filled
Ξ²-blockers
CCBβ verapamil, dilatazlam
Restrictive Cardiomyopathy pathophys
Stuff gets in way of ventricle wall other than myocytes β β₯ canβt relax
Restrictive Cardiomyopathy sx
Diastolic CHF
Amyloid β peripheral neuropathy
Sarcoid β pulmonary dz
Hemochromatosis β cirrhosis or bronze diabetes
Restrictive Cardiomyopathy dx
Echo β restrictive pattern
Amyloid β fat pad or gingiva bx
Sarcoid β cardiac MRI + endomyocardial bx
Hema β screen w/ ferritin (will be β) + genetic test
Restrictive Cardiomyopathy tx
Manage underlying dz
Definitive tx = transplant
Goal: rate control + control HTN
Ξ²- blockers
CCB
Gentle diuresis
R sided HF
R sided β₯ failure β β blood to lungs β β blood to LV and β blood to periph
L sided HF
L sided β₯ failure β blood canβt get out of LV β lungs drown with fluid bc RV still works
Diastolic dysfn
Diastolic Dysfn β β₯ gets big and beefyβ thick ventricle β canβt relax β β or nrml Ej frac
Systolic dysfn
Systolic dysfnβ LV weakβ canβt get blood out of β₯ β β ej frac < 50%*
Congestive Heart Failure sx
DOE, orthopnea, PND
Lateral displaced PMI + S3
JVD, peripheral edema, hepatosplenomegaly
L-sided will have crackles
Wt gain d/t fluid retention
Congestive Heart Failure dx
BNP β released when R atrium stretches (will show β vol but not specific)
2D Echo β ej frac, pulm arterial press, diastolic vs systolic
Lβ₯ cath angiogram β determine ischemic vs not
Congestive Heart Failure tx
Smoking cessation
<2 L fluid/day
<2 gm NaCl/ day (bc water follows salt)
Ξ²-blocker + ACE-I (or ARB)
+ loop diuretic if class II
+ Spironolactone or Bidil if class III
+ Inotropes if class IV
CHF Exacerbation dx
CXR β β for vol overload
EKG β β for STEMI or arrhythmia causing CHF
BNP β β for vol overload
Troponin β β for NSTEMI
CHF Exacerbation tx
Lasixβ get rid of excess fluid
Morphine β dyspnea + vasodilate pool fluid away from lungs
Nitrates β vasodilate pool fluid away from lungs
Oxygen
Position β sit up to prevent orthopnea
Atherosclerosis tx
Smoking cessation, control HRN, treat DM, + dyslipidemia
BMI <25, <40 in WC
Aerobic exercise
Low sat far, low trans fat and low cholesterol diet high in fiber and rich in veggies, fruti and hwole grains
Endocarditis etiology
S. aureus = MC
2nd MC = Strep viridans
Enterococci
IV drug users β S. aureus MC
Endocarditis pathophys
Infection d/t direct intracascular contamination
Vegetations, fibrin, inflammation, organisms
Endocarditis sx
New regurgitation murmur, HF, evidence of embolic events, peripheral lesions (petechiae, splinter hemorrhages, orth spots), fever
Osler nodes + Janeway lesions
Endocarditis dx
Blood cx x 3 at least 1 hr apart
EKG
ECHOβ vegetation + ID affected valves
Duke criteria β determine criteria
Endocarditis tx
Empiric therapy β IV vanc (or ceftriaxone) + gentamicin + cefepime or carbapenem x 6 wks
Ppx for HIGH risk groups prior to procedures that have high risk for bacteremia β prosthetic valves, cyanotic congenital heart defet
Amoxicillin 2 g 30-60 min before procedure
Mitral Stenosis etiology
Rheumatic β₯ dz
Inflam of mitral valve
Mitral Stenosis sx
Atrial stretch + fluid in lungs drive the sx
CHF sx β βDOE, PND, crackles
Afib
Rumbling diastolic murmur heard best at apex 5th ICS MCL, opening snap
Mitral Stenosis tx
Balloon valvuloplasty β opens up valve so blood flows normally again
Replacement
β volume
Afterload reduction + diuresis
Aortic Stenosis etiology
Atherosclerosis β calcium deposits
Aortic Stenosis sx
Heart failure sx, CP, syncope
Systolic, 2nd ICS RSB (base of β₯), crescendo-decrescendo
Aortic Stenosis tx
Valve replacement
β volume
Afterload reduction + diuresis
Lipid lowering drugs
Statins (HMGcoA Reductase Inhibitors) β only one that β MI/Strokes
High Intensity = Atorvastatin, Rosuvastatin
Niacin/Nicotinic Acid (Vit B3)
Fibrates β Gemfibrozil, Fenofibrate
Bile Acid Sequestrants β Cholestyramine, Colestipol, Colesevelam (β TGs)
Ezetimibe/Zetia
PCSK9 Inhibitors (-mabs)
Pericarditis tx
NSAIDs + colchicine
Avoid NSAIDs in CKD, thrombocytopenia, PUD
Colchicine β dose lim by diarrhea
Can go to steroids if refractory but β risk of recurrence w/ steroids (esp if d/t viral etiology)
Rheumatic fever tx
Anti-inflam β ASA w/ taper (+/- CCS if carditis/severe)
ABX β PCN G for Strep (Erythro if PCN allergy) acute phase & AFTER (prevention = imp)
Short PR and widened QRS
WPW
secondary pphx for GAS after pt has acute rheumatic fever
needs to be for 10 yrs or until 40 yo
Pen G IM q 21-29d
Pen V 250 mg po BID
If PCN all then Azithromycin 250 mg po BID
ststins that dec size of atheromas
rosuvastatin and atorvastatin
non statin lipid lowering agent with additive prevention of CV adverse events
Ezetimibe
Dx TOC for ID valvular vegetations in at risk pts
TEE
GS to locate PVD
angiography
Mc cause of exacerbation of PVD
emboli
split S2, clubbing, cyanosis, tricupsid regurg and inc HVP
Pulm HTN
Becks Triad
hypotension, JVD, muffeled heart sounds
assoc w/ cardiac tamponade
V1 and V2
septal (prox LAD)
V1-V4
Anterior (LAD)
I, avL, v5 and v6
Lateral (circumflex)
I, avL, v4, v5. v6
Anterior lat (mid LAD or CFX)
II, III, aVF
inferior (RCA)
II, III, aVF
inferior (RCA)
Which beta-blockers have a proven mortality benefit in the treatment of heart failure?
Carvedilol, metoprolol succinate and bisoprolol
Which beta-blockers have a proven mortality benefit in the treatment of heart failure?
Carvedilol, metoprolol succinate and bisoprolol
hat cardiac complication is associated with hyperthyroidism?
Atrial dysrhythmias and high cardiac output failure
hat cardiac complication is associated with hyperthyroidism?
Atrial dysrhythmias and high cardiac output failure
Which virus is the most common cause of acute viral pericarditis?
coxsackie virus
Which virus is the most common cause of acute viral pericarditis?
coxsackie virus
s3
restrictive cardiomyopathy
pericardial knock
constrictive pericarditis
pericardial knock
constrictive pericarditis
What are the components of the San Francisco syncope rule
History of CHF, hematocrit <30%, abnormal ECG, dyspnea, systolic BP <90βdefines high-risk criteria for patients with syncope
What are the components of the San Francisco syncope rule
History of CHF, hematocrit <30%, abnormal ECG, dyspnea, systolic BP <90βdefines high-risk criteria for patients with syncope
egg shaped heart
transposition of the great arteries
egg shaped heart
transposition of the great arteries
snowman heart
total anomalous pulmonary venous return
What coronary artery supplies the AV node?
RCA
chest pain early in the AM
Prinzmetal angina (variant angina)
In patients with a myocardial infarction, which three drugs have been shown to decrease mortality?
Aspirin, beta-blockers, and ACE-inhibitors