Cardio Flashcards
What type of drugs rapamil?
Non-dihydropyridine calcium channel blocker
What is the method of action and indication of methotrexate?
Inhibition of folic acid
Acute lymphoblastic leukaemia
What type of drug is coversyl?
Perindopril
What type of drug is nifedipine? Indications? Side effects?
Dihydropyridine calcium channel blocker (peripheral vasodilator)
HTN, angina
Peripheral oedema that doesn’t respond to diuretics
Which node is ablated in AF?
AV
What is frusemide? How does it work? How does it effect electrolytes
Loop diuretic
Acts on the thick ascending limb of loop of Henle
Causes K+ loss due to increased Na+ in collecting duct (actions of aldosterone)
What is ototoxic mean?
Toxic to the ear - specifically the cochlea or auditory nerve
What is spirolactone?
K-sparring diuretic > aldosterone receptor antagonist
What are the indications for amiodarone?
Treatment and prophylaxis for serious tachyarrhythmias that are refractory other treatment eg ventricular tachycardia, AF and SVT
What is the mechanism of action of metoclopramide?
Blocks dopamine receptor (and when given at higher doses) serotinin receptors in the chemoreceptor trigger zone in the CNS
Enhances the activity of ACh in the gut to increase motility
What is the mechanism of action of amiodarone?
Decreases sinus node and junctional automaticitiy,
Slows atrioventricular (AV) and bypass tract conduction
Prolongs refractory period of myocardial tissues (atria, ventricles, AV node and bypass tract)
Also has weak beta-blocker activity.
What are some side effects of amiodarone?
Pulmonary fibrosis
Thyrotoxicosis or hypothyroid
Vision changes - yellow vision, reversible
Which diuretic is used in HTN?
Thiazides
What type of drug is amlodipine?
Dihydropyridine calcium channel blocker (peripheral vasodilator)
