Antidepressants Flashcards

1
Q

What is the mechanism of action of SSRIs?

A

Selectively inhibit the reuptake of serotonin at the presynaptic cleft

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2
Q

Name some SSRIs?

A

Escitalopram - Lexapro

Sertraline - Zoloft

Citalopram - Celexa

Dapoxetine - Priligy

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3
Q

What are some adverse affects of SSRIs?

A

Nausea

Dizziness

Weight gain / loss

Sexual dysfunction

Drowsiness

Extrapyramidal side effects

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4
Q

What are the extrapyridimal side effects?

A

Tardive dyskinesia

Dystonia

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5
Q

What are the indications for SSRIs?

A

Major depression

Bulimia nerosa

Anxiety

Premenopausal dysphoric disorder

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6
Q

What are some precautions for SSRI use?

A

Epilepsy

Bipolar disorder

Bleeding

Hepatic impairment

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7
Q

What is the mechanism of action of tricyclic antidepressants?

A

Block noradrenaline and serotonin reuptake into the presynaptic neuron

Also block cholinergic, histaminergic, alpha1-adrenergic, and serotonergic receptors

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8
Q

What are the indications for TCAs?

A

Major depression

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9
Q

What are some adverse effects of TCAs?

A

Decreased SLUD

Sedation

Orthostatic hypotension

Sinus tachycardia

Slow cardiac conduction

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10
Q

Name some TCAs

A

Amitripyline - Endep

Clomipramine

Dothiepin

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11
Q

When do you expect the therapeutic effects of TCAs to set in?

A

2 weeks

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12
Q

What is the mechanism of action of MAOI’s?

A

Non-selective inhibit monoamino oxidase A and B to increase the concentration of adrenaline, noradrenaline, dopamine, and serotonin at the synaptic cleft

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13
Q

What are the indications for MAOi’s?

A

Major depression - second line

Some anxiety disorders

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14
Q

What are some adverse effects of MAOis?

A

Orthostatic hypotension

Sleep disturbance

Headache

Drowsiness

Fatigue

Weakness

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15
Q

Name some MAOi’s?

A

Phenelzine

Tranylcypromine

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16
Q

What is venlafaxine? What is its mechanism of action?

A

It is a serotonin and noradrenaline reuptake inhibitor

17
Q

What are the SNRIs?

A

Venlafaxine - effexor

Desvenlafaxine - pristiq

Duloxetine - cymbalta

18
Q

What are some adjunct therapy to the regular antidepressants?

A

Benzodiazapenes for insomnia

Lithum for refractive depression

19
Q

Which class of antidepressant is considered first line?

A

SSRIs

20
Q

What is tardive dyskinesia?

A

Irregular, jerky movements