cardio 3.1 Flashcards

1
Q

where can we find intra-alveolar pressure (intrapulmonary)

A

In the lungs

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2
Q

through what two forces is negative intrapleural pressure established

A

1) The lungs natural tendancy to recoil
2) The surface tension of the alveolar fluid (surfactant) constantly cacts to draw the alveoli to their smallest possible demension

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3
Q

what opposes the lung collapsing forces

A

The natural elasticity of the chest wall, pulls the thorax outward, and and enlarges the lungs.

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4
Q

what allows the negative pressure of the lungs and the elastissticity of the chest wall to coexist

A

the strong adhesive force between the parietal and visceral pleura (think water between two pieces of glass)

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5
Q

what pressures are involved in breathing (4)

A
  • atmospheric pressure
  • intra-alveolar pressure
  • intrapleural pressure
  • transpulmonary pressure
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6
Q

what pressures keeps the lungs from collapsing

A

the difference between the intrapulmonary and intrapleural pressures (Ppul - Pip)

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7
Q

what determins the size of the lungs at any given time

A

thanspulmonary pressure (greater the pressure, the larger the lungs)

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8
Q

what is Boyle’s law

A

P1V1 = P2V2

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9
Q

what is alveolar pressure equal to at rest

A

atmospheric pressure (alveolar pressure = 0)

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10
Q

what is the intrapleural pressure at rest

A

Negative, the opposing forces of the lungs are trying to collapse and the chest wall trying to expand a negative pressure in the intrapleural space

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11
Q

what is the Lung volume at rest

A

FRC (think waves)

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12
Q

when inspiratory muscles contract, what occurs to the thorax

A

volume increases

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13
Q

what happens to the alveolar tissue pressure as the lung volume increases

A

decreases to less then atmospheric pressure

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14
Q

as the pressure in the lungs becomes negative, what occurs

A

airflow will continue until the pressure radiant dissipates

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15
Q

what happens to the interpleural pressure during inspiration

A

it becomes more negative

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16
Q

what occurs as the lung volume increases concerning recoil and the interpleral space

A

the elastic recoil strength increases- as a result the interpleural space becomes even more negative

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17
Q

how much will the lung volume increase by in a normal inspiration

A

One TV

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18
Q

during expiration, what occurs to the the alveolar pressure

A

becomes greater than atmospheric pressure (due to increases elastic forces on the lungs)

19
Q

what happens to the interpleural pressure when

1) Normal expiration
2) forced expiration

A

1) intrapleural pressure returns to normal

2) intrapleural pressure becomes positive

20
Q

how does positive pressure effect expiration

A

makes it more difficult

21
Q

energy obtained during expiration help over come what 3 factors

A
  • airway resistance
  • alveolar surface tension
  • lung compliance
22
Q

how does contraction and relaxation of bronchial smooth muschle effect airway resistance

A

it alters the radius of the airways

23
Q

what effect does parasympathetic stmilation have on the airways

A

constricts the airway (muscurinic agonist, irritants and the slow reacting substances on anaphylaxis)

24
Q

sympathetic stimuilation and sympathetic agonist do what

A
  • dilate the airway via beta2 receptors
  • increase the radius
  • decrease the resistances to airflow
25
what is Laplace's Law
P=2T/R P=collapsing pressure on the alveolus or pressure required to keep alveolus open T=surface tension r=raduis of the alveolus
26
what role does pulmonary serfactant play
helps prevent collapse of the alveoli within the lung
27
what is surfactant composed of
phospholipid DPPC and other lipids, proteins and carbohydrate
28
why are phospholipids considered to be the major component in surfactant
due to its amphipathic properties
29
what is the function of surfactant
to lower surface tension and subsequently \reduce the tendency of alveoli to collapse completely
30
what happens to the alveolus as it gets bigger
the collapsing pressure decreases, and they become easier to keep open.
31
fancy word for collapse
atelectasis
32
what is complience and what is the formula
the change in colume for a giben change in pressure | C=V/P
33
what decreases complience
high expanding pressures, creating stiffer lungs (the more energy it takes to breath)
34
what begins an asthma attack
when an allergen is inhaled and binds to IgE antibodies on the mas cell in the lungs
35
what is released once IgE is bound
Histamine | Leukotrienes
36
what are the 6 common environmental triggers of asthma
1) house dust mites 2) cockroach allergen 3) animal allergens 4) pollen allergens 5) mold allergens 6) nonallergic airborne irratants
37
what are the two stages of asthma caused by histamine and leukotrienes
- 1st early phase or reaction occur within 1 hout of exposure to allergen - 2nd attract an accumulation of inflamitory cells this developes the LATE PHASE usually 4-5 hours after exposure
38
true or false: it is not suspected that there is a genetic aspect of allergies
False
39
as asthma progresses attacks can be triggered by non-specific factors like what
Cold air, exercise, and tobacco smoke.
40
asthma is physiologically and pathologically charecterized by what 4 things?
- increased resonsiveness of the trachea and bronchi - contraction of airway smooth muscle - mucosal thickening from edema and cellular infiltration - collection of abnormally thick plugs of mucus in the airways
41
what are the two most common causes of obstructive lung disease
chronic obstructive pulmonary disease (COPD) | Asthma
42
what are some condition that cause restrictive lung disease(3)
- interstitial lund disease such as idiopathic pulmonary fibrosis - obesity - neuromuscular disease, such as muscular dystrophy or amyotrophic lateral sclerosis
43
how is airflow measured
the subject exhales as rapidly as possible into a spirometer and measuring forced expiratory volume
44
how much air should a health adult be able to expel in 1 second
75-85% of the vital capacity.