2C regulation of cardiac output via heart rate Flashcards
cardiac output cant be manipulated in what who way
SV(stroke volume) and heart rate
Parasympathetic system has what effect of the heart rate
negative chronotropic effects
sympathetic system has what effect on the heart rate
positive chronotropic effects
what parts of the heart have parasympathetic vegal innervation
SA node, atria, and AV node
what receptors does acytocholine attach to
muscarinic receptors
what is the chronotropic effect
- decreased heart rate (decreases phase 4 depolorization)
- fewer action potential occur per unit time because the threshhold potential is reached more slowly
by what mechanism does chronotropic effect work
decreases I(f), the inward Na+ current that is responsible for phase 4 depolorization in the SA node
what parts of the heart have sympathetic innervation
SA node, atri, AV node and ventricles
what is the sympathetic neurotransmitter and what does it bind to
Norepinephrine, binds to Beta1 receptors
what are the effects of positive chronotropic effect
increased heart rate
more action potentials
what is the mechanism for positive chronotropic effect
increased I(f) the inward NA+ cerrent what is responsible for phase 4 depolarization in the SA node
continue in slides
three to the end