Cardio Flashcards
Medical co-morbidities increase the risk of atherosclerosis and should be carefully managed to minimise the risk
- Diabetes
- Hypertension
- Chronic kidney disease
- Inflammatory conditions e.g. RA
- Atypical antipsychotic medications
end result of atherosclerosis
- Angina
- Myocardial infarction
- Transient ischaemic attacks
- Strokes
- Peripheral arterial disease
- Chronic mesenteric ischaemia
scoring system that estimates the percentage risk that a patient will have a stroke or myocardial infarction in the next 10 years
QRISK
CVD primary prevention medication and indications
Atorvastatin 20mg to all patients with:
- CKD (eGFR < 60 ml/min/1.73 m2)
- T1DM for>10 years or are 40+ yrs
- QRISK >10%
how do statins reduce cholesterol production
in the liver by inhibiting HMG CoA reductase
blood test after starting a statin
- check lipids 3 months after starting statins and increasing the dose to aim for a greater than 40% reduction in non-HDL cholesterol
- LFTs within 3 months of starting a statin and again at 12 months. Can cause slight increase in ALT and AST initially. Ok so long as <3x normal
rare and significant side effects of statins
- Myopathy
- Rhabdomyolysis
- Type 2 diabetes
- Haemorrhagic strokes (very rarely)
medication that interacts with statins
macrolides (erythro/calrithromycin)
other cholesterol lowering drugs
- Ezetimibe: inhibits the absorption of cholesterol in the intestine. Can combine with bempedoic acid, a drug that reduces cholesterol production in the liver.
- PCSK9 inhibitors (e.g., evolocumab and alirocumab) are monoclonal antibodies that lower cholesterol.
Secondary prevention of CVD
4A’s
A – Antiplatelet medications (e.g., aspirin, clopidogrel and ticagrelor)
A – Atorvastatin 80mg
A – Atenolol (or alternative BB) titrated to the max tolerated dose
A – ACE inhibitor (commonly ramipril) titrated to the max tolerated dose
medication post MI
dual antiplatelet treatment with:
- Aspirin 75mg daily (continued indefinitely)
- Clopidogrel or ticagrelor (generally for 12 months before stopping)
Management of familial hypercholesterolaemia involves:
- Specialist referral for genetic testing and testing of family members
- Statins
what is angina
caused by atherosclerosis affecting the coronary arteries, narrowing the lumen and reducing blood flow to the myocardium
Immediate sx relief for angina
- GTN: vasodilation
Long term sx relief for angina
- Beta blocker (e.g., bisoprolol)
- Calcium-channel blocker (e.g., diltiazem or verapamil – both avoided in heart failure with reduced ejection fraction)
Medications for secondary prevention of angina
4As mnemonic:
A – Aspirin 75mg once daily
A – Atorvastatin 80mg once daily
A – ACE inhibitor (if diabetes, hypertension, CKD or heart failure are also present)
A – Already on a beta blocker for symptomatic relief
Vessels used in CABG
- Saphenous vein (harvested from the inner leg)
- Internal thoracic artery, also known as the internal mammary artery
- Radial artery
Two coronary arteries branch from the root of the aorta
Right coronary artery (RCA)
Left coronary artery (LCA)
RCA curves around the right side and under the heart and supplies
- Right atrium
- Right ventricle
- Inferior aspect of the left ventricle
- Posterior septal area
left coronary artery becomes the
Circumflex artery
Left anterior descending (LAD)
circumflex artery curves around the top, left and back of the heart and supplies the
Left atrium
Posterior aspect of the left ventricle
left anterior descending (LAD) travels down the middle of the heart and supplies the:
Anterior aspect of the left ventricle
Anterior aspect of the septum
patients at risk of silent MI
diabetics
ECG changes in STEMI and NSTEMI
STEMI: LBBB and ST elevation
NSTMI: ST depression, T wave inversion