Cardiac Glycosides

Question 1

Example of cardiac glycoside

Answer 1

digoxin (Lanoxin)

Question 2

MOA of digoxin

Answer 2

increases intracellular calcium
inotropic (+)
chronotropic (-)
dromotropic (-)
increased cardiac output and renal perfusion
decreased myocardial workload and relief of HF

Question 3

Indication of digoxin

Answer 3

treatment of HF, atrial flutter, atrial fibrillation
paroxysmal atrial tachycardia

Question 4

reduces the therapeutic effects of digoxin

Answer 4

rifampin, barbiturates, antacids, neomycin, metoclopramide

Question 5

increase the risk of digoxin toxicity

Answer 5

calcium preparations, verapamil, quinidine, tetracycline, spironolactone, and
omeprazole

Question 6

amphotericin B, potassium-wasting diuretics, and steroids may cause
hypokalemia

Answer 6

increase the risk of digoxin toxicity