Antimycobacterials

Question 1

is an acid-fast aerobic rod that grows slowly and is
sensitive to heat and ultraviolet light

Answer 1

Mycobacterium tuberculosis

Question 2

less toxic and are used to treat drug-susceptible tuberculosis

Answer 2

FLD (first-line drugs)

Question 3

FLD drugs

Answer 3

rifampicin (R), isoniazid (H), pyrazinamide (Z)
enthambutol (E)

Question 4

are more toxic which are reserved for the treatment of drug-resistant tuberculosis (DR-TB)

Answer 4

SLD (second-line drugs)

Question 5

SLD drugs

Answer 5

streptomycin (S)
amikacin
delamanid (Dlm)
levofloxacin (Lfx)
Clofazamine (Cfz)
linezolid (Lzd)
prothionamide (Pto)
cycloserine

Question 6

alters RNA and DNA synthesis resulting to the blockage of key
metabolic pathways needed for mycobacterium cell growth and
replication

Answer 6

Rifampicin (Rifampin, Rifadin)

Question 7

• inhibits synthesis of mycolic acid, an important component of
  bacterial cell wall
• mainstay in the prevention and treatment of tuberculosis

Answer 7

Isoniazid, INH (Laniazid, Nydrazid)

Question 8

inhibits nucleic acid synthesis

Answer 8

Pyrazinamide, PZA

Question 9

alters cellular RNA synthesis and phosphate metabolism

Answer 9

Ethambutol (Myambutol)

Question 10

Ethambutol (Myambutol)

Answer 10

Delamanid (Deltyba)

Question 11

inhibits synthesis of mycolic acid

Answer 11

Prothionamide (Protomid, Prothiocid)

Question 12

inhibits bacterial cell wall synthesis

Answer 12

inhibits synthesis of ATP