Cardiac drugs Flashcards
Atorvastatin
Hypercholesterolaemia
Lipid regulating
inhibit the action of HMG-CoA reductase
Lisinopril
Hypertension, HF, MI
ACE inhibitor
Mechanisms: blocks angiotensin I becoming angiotensin II
Side effects: cough, renal dysfunction, angioneurotic oedema
Bendrofluazide
hypertension
thiazide diuretics
Mechanism: blocks Na reabsorption in kidneys
Nicorandil
K ATP channel activator
side effect: headache, mouth/GI ulcers
Vasodilator
Angina
Amlodipine
Calcium antagonist
hypertension and angina
side effect: ankle oedema
Ticagrelor
Antiplatelet
Prevent new thrombosis
Angina, acute MI, high risk of MI
Verapamil
CCB
relatively selective for cardiac cells
used in hypertension, angina
side effects: hypotension, dizziness, swollen ankles
Amlodipine
CCB
selective for smooth muscle L type channels
used in hypertension, angina
Dihydroperidines
Anti platelet drugs
aspirin, clopidogrel, ticagrelor
prevent new thrombosis
used in: angina, acute MI
side effects: haemorrhage anywhere, peptic ulcer
anti coagulants
heparin- IV only warfarin- oral only slows down clotting > prevent new thrombosis used in: DVT, PE, NSTEMI, AF side effects: haemorrhage
Heart failure drugs
ACEi ARBs beta-blockers mineralocortocoid antagonists (spironolactone) diuretics digoxin
hypertension
thiazide diuretics
beta blockers
CCB, alpha blockers, ACEi, ARBs
Diuretics
block Na reabsorption into kidneys
thiazide or loop
side effects: hypokalaemia, arrhythmias, hyperglycaemia
thiazide diuretics
mild
eg bendrofluazide
used in hypertension
Loop diuretics
stronger
eg furosemide
used in heart failure
