Cardiac drugs Flashcards
Atorvastatin
Hypercholesterolaemia
Lipid regulating
inhibit the action of HMG-CoA reductase
Lisinopril
Hypertension, HF, MI
ACE inhibitor
Mechanisms: blocks angiotensin I becoming angiotensin II
Side effects: cough, renal dysfunction, angioneurotic oedema
Bendrofluazide
hypertension
thiazide diuretics
Mechanism: blocks Na reabsorption in kidneys
Nicorandil
K ATP channel activator
side effect: headache, mouth/GI ulcers
Vasodilator
Angina
Amlodipine
Calcium antagonist
hypertension and angina
side effect: ankle oedema
Ticagrelor
Antiplatelet
Prevent new thrombosis
Angina, acute MI, high risk of MI
Verapamil
CCB
relatively selective for cardiac cells
used in hypertension, angina
side effects: hypotension, dizziness, swollen ankles
Amlodipine
CCB
selective for smooth muscle L type channels
used in hypertension, angina
Dihydroperidines
Anti platelet drugs
aspirin, clopidogrel, ticagrelor
prevent new thrombosis
used in: angina, acute MI
side effects: haemorrhage anywhere, peptic ulcer
anti coagulants
heparin- IV only warfarin- oral only slows down clotting > prevent new thrombosis used in: DVT, PE, NSTEMI, AF side effects: haemorrhage
Heart failure drugs
ACEi ARBs beta-blockers mineralocortocoid antagonists (spironolactone) diuretics digoxin
hypertension
thiazide diuretics
beta blockers
CCB, alpha blockers, ACEi, ARBs
Diuretics
block Na reabsorption into kidneys
thiazide or loop
side effects: hypokalaemia, arrhythmias, hyperglycaemia
thiazide diuretics
mild
eg bendrofluazide
used in hypertension
Loop diuretics
stronger
eg furosemide
used in heart failure
Dobutamine
Beta1 agonist
used in severe HF
Side effects of nitrates
can cause a decrease in intracellular calcium > causing hypotension
drug that inhibits prostaglandin synthesis in patent ductus arteriosus
Indomethacin or ibuprofen
prostoglandin E1 only used if patient requires surgery
side effects of atorvastatin
liver impairment, myopathy
