Cardiac drugs

Question 1

How does aspirin work?

Answer 1

Inhibitis production of thromboxane A2

Question 2

How does clopidogrel work

Answer 2

Prevents binding of ADP and platlet aggregates (P2Y12)

Question 3

When should you stop an antiplatelet before surgery?

Answer 3

7 days.

Question 4

How does amiodarone work?

Answer 4

Blocks potassium channels.

Question 5

Side effects of amiodarone?

Answer 5

Lung fibrosis
Photo toxic (amiodarone glow)
Peripheral neuropathy
Visual - dazzled by bright lights

Question 6

What class of drugs can cause gingival hypertrophy?

Answer 6

Calcium channel blockers.

Question 7

Side effects of beta bloclkers

Answer 7

Erectile dysfunction

Cold peripheries.

Question 8

What drug can cause anal ulceration?

Answer 8

Nicorandil (potassium channel opener)

Question 9

Patients can develop tolerance to what cardiac drug?

Answer 9

Nitrates.

Question 10

How do statins work?

Answer 10

They inhabit HMG-COa, the rate limiting step in cholesterol production.

Question 11

Side effects of statins?

Answer 11

Myalgia, rhabdomyolysis.

Question 12

Alternative to statin?

Answer 12

Fibrates.