Carbapenems And Monobactam

Question 1

Which drug is combine with imipanam? What does it do

Answer 1

Cilastatin, A dehydropeptidease inhibitor
increases the concentration of imipenem in urine

Question 2

What is the spectrum of activity of carbapenams

Answer 2

Gram-positive organisms: streptococci, staphylococci, enterococci, listeria and C. difficile
gram-negative organisms: P aeruginosa, enterobacteriaceae, B. fragilis

Question 3

What are the uses of imipenem-cilastatin

Answer 3

Bacterial mixed infections
1. Bone and joint infections
2. soft tissue infections
3. skin infections
4. gynaecological infections
5. intra-abdominal infections
6. respiratory infections
7. urinary infections

Question 4

Name Carbapenams

Answer 4

1. Imipenem
2. meropenem
3. Doripanem
4. ertapenam
5. feropenam

Question 5

What are the adverse effects of imipenem cilastatin

Answer 5

1. Cross-reactivity with penicillins and cephalosporins
2. nausea, vomiting, skin rashes
3. rarely seizures

Question 6

Which carbapenams are not destroyed by dehydropeptidease

Answer 6

1. Meropenem
2. DoriPanem

Question 7

Name a monobactam

Answer 7

Aztreonam 

Question 8

Which group of bacteria are monobactam’s active against

Answer 8

Only gram-negative bacteria

Question 9

What is the route of administration of aztreonam

Answer 9

 parenterally 

Question 10

What is the mean advantage of aztreonam

Answer 10

Lack of cross activity with other beta lactam antibiotics

Question 11

What is the one drug that is aztreonam Causes reaction with

Answer 11

Ceftazidime