Cannabinoids

Question 1

Cannabis is lipid soluble and concentrated in fat, meaning…

Answer 1

It crosses membranes easily, rapidly distributes into the brain, distributes in fat, and stays longer there than less soluble molecules. This means that trace amounts can be found weeks after somebody ingested cannabis.

Question 2

Which family of cannabinoid receptors is the most abundant/populous receptor in the brain?

Answer 2

CB1

Question 3

Even at low amounts (2-5 ng/ml plasma), below the threshold of experiencing psychoactive effects (feeling high), cannabis ________ reaction time.

Answer 3

decreases

Question 4

Chronic/heavy cannabis users who want to quit ingesting it will go into some form of withdrawal, the most common symptom of which is

Answer 4

irritability

Question 5

the LD50 / toxicity of cannabis is _____ for humans

Answer 5

unknown

Question 6

Rimonabant is a cannabinoid-1 receptor blocker and inverse agonist for cannabinoid receptor CB-1
used for marijuana dependence and…

Answer 6

weight loss in obese patients

Question 7

A synthetic cannabinoid used primarily as an antiemetic for nausea and vomiting caused by chemotherapy, which mimics THC, the primary psychoactive compound found in cannabis.

Answer 7

nabilone

Question 8

A nonpsychoactive cannabinoid that contains antiepileptic properties when used to treat serious and rare forms of seizures and sclerosis. It is safer than most drugs and has no evidence of tolerance, addiction, or overdose.

Answer 8

cannabidiol (CBD)

Question 9

Relatively safe and effective synthetic cannabinoid medication derived from cannabis, the active ingredient in _____ which is primarily indicated for the treatment of HIV/AIDS-induced anorexia. Acts as a partial agonist at CBR in the CNS.

Answer 9

dronabinol