Cancer 4 (02.27)

Question 1

There is a correlation b/t the size and extent of spread of cancer and severity of

Answer 1

Cachexia

Question 2

1 symptom of hypercalcemia of malignancy

Answer 2

Nausea

Question 3

2nd and 3rd most common symptoms of lung cancer

Answer 3

Hemoptysis, Dyspnea

Question 4

2nd most common cause of new lung cancers

Answer 4

Radon

Question 5

2nd most common source of ACTH causing Cushing Syndrome

Answer 5

Small Cell Carcinoma of Lung

Question 6

3 most common paraneoplastic syndromes

Answer 6

Hypercalcemia, Cushing (ACTH), Carcinoid Syndrome (Serotonin)

Question 7

3 most common symptoms of Colon Cancer

Answer 7

Abdominal pain, Change in bowel habits, Hematochezia or melena

Question 8

3rd most common cause of new lung cancers

Answer 8

Passive Smoking

Question 9

Basement membrane about 10x normal size is a feature of

Answer 9

Chronic smoking

Question 10

BCR-ABL is seen in

Answer 10

Chronic Myeloid Leukemia

Question 11

Bronchiole with necrotizing inflammation, infiltration of lymphoctyes and PMNs, accumulation of mac’s with brown/black pigment

Answer 11

Respiratory Bronchiolitis

Question 12

Buffalo Hymp is seen in

Answer 12

Cushing Syndrome

Question 13

Carcinoid Syndrome symptom

Answer 13

Attacks of cutaneous flushing (deep red erythema of face and neck)

Question 14

Cushing syndrome arising as paraneoplastic phenomenon is usually related to

Answer 14

ectopic production of ACTH or ACTH-like polypeptides by cancer cells

Question 15

Dx of Prostate Cancer usually follows

Answer 15

screening for PSA or rectal exam

Question 16

Function of Proteolysis-Inducing Factor

Answer 16

Breakdown of skeletal muscle proteins by ubiquitin-proteosome pathway

Question 17

Incidence of Paraneoplastic Syndromes

Answer 17

10-15% of patients with cancer

Question 18

Keratin Pearl

Answer 18

Seen in squamous cell carcinoma of lung

Question 19

Kertin Pearl indicates

Answer 19

Squamous Cell Carcinoma

Question 20

Marker for HCC

Answer 20

AFP

Question 21

Most common lung cancer type to cause hypercalcemia

Answer 21

Squamous cell carcinoma

Question 22

Most common Paraneoplastic Syndromes

Answer 22

Hypercalcemia, Cushing, Nonbacterial Thrombotic Endocarditis

Question 23

Most common source of ACTH causing Cushing Syndrome

Answer 23

Pituitary Adenoma

Question 24

Most common symptom of lung cancer

Answer 24

cough

Question 25

Most important mechanisms of hypercalcemia in paraneoplastic syndrome

Answer 25

Synthesis of Parathyroid Hormone-related protein by tumor cells

Question 26

Neoplasms most associated with Paraneoplastic Syndromes

Answer 26

Lung, breast, and hematologic malignancies

Question 27

Non-paraneoplastic syndrome cause of hypercalcemia

Answer 27

Widespread osteolytic metastatic disease of bone

Question 28

Paraneoplastic syndromes occur in what percent of cancer patients

Answer 28

10%

Question 29

PCR-based detection of T cell receptor or Ig allows

Answer 29

distinction between monoclonal (neoplastic) and polyclonal (reactive) proliferations

Question 30

Percent of lung cancer patients with symptoms at Dx

Answer 30

90%

Question 31

Percent of women with no symptoms at time of dx of breast cancer

Answer 31

55%

Question 32

Regenerative nodules of hepatocytes completely surrounded by fibrous tissue with numerous lymphocytes

Answer 32

Cirrhosis

Question 33

Respiratory Bronchiolitis =

Answer 33

Smoking

Question 34

Role of TNF in Cachexia

Answer 34

Suppresses appetite and inhibits action of lipoprotein lipase, inhibiting release of FFA’s from lipoproteins

Question 35

T/F: The vast majority of prostate cancer patients have no symptoms at Dx

Answer 35

TRUE

Question 36

Type of cancer most likely to cause paraneoplastic syndrome

Answer 36

Small Cell Carcinoma (neuroendocrine tumor)

Question 37

When is PSA test most valuable

Answer 37

for detecting residual diseae or recurrent following treatment