Cancer

Question 1

Woman with bone metastases

Answer 1

most likely to originate in the breast

Question 2

testicular cancer

Answer 2

Infertile men are 3 times more likely to develop testicular cancer

Question 3

breast cancer patients who are node +ve

Answer 3

FEC-D chemotherapy

Question 4

high calcium, normal/high phosphate and normal alkaline phosphate

Answer 4

Myeloma without metastasis

Question 5

breast associated with reddening and thickening of the nipple/ areola. It may resemble eczema.

Answer 5

Paget’s disease of the breast

Question 6

HIV, neuro symptoms, single brain lesions with homogenous enhancement

Answer 6

CNS lymphoma

Question 7

Adjuvant hormonal therapy for ER +ve breast cancer:

Answer 7

anastrozole in post-menopausal women

Question 8

second most common association of HNPCC after colorectal cancer

Answer 8

Endometrial cancer

Question 9

> = 50 years of age presenting with symptoms suggestive of irritable bowel syndrome in the last 12 months.

Answer 9

Suspect ovarian cancer in any woman

Question 10

Hodgkin’s lymphoma: signs of poor prognosis

Answer 10

B-symptoms, increasing age, male sex, stage IV disease and lymphocyte depleted subtype

Question 11

Hashimoto’s thyroiditis is associated with the development of which cancer?

Answer 11

MALT lymphoma

Question 12

‘CRAB’ features of multiple myeloma =

Answer 12

hyperCalcaemia, Renal failure, Anaemia (and thrombocytopenia) and Bone fractures/lytic lesions

Question 13

Schistosomiasis

Answer 13

Schistosomiasis is a risk factor for squamous cell carcinoma of the bladder

Question 14

• imatinib

Answer 14

Chronic myeloid leukaemia - imatinib = tyrosine kinase inhibitor

Question 15

Atypical lymphocytes

Answer 15

?glandular fever

Question 16

duct ectasia

Answer 16

Brown-green nipple discharge

Question 17

HRT: unopposed oestrogen

Answer 17

increases risk of endometrial cancer

Question 18

raised calcitonin?

Answer 18

Medullary thyroid cancer