Calcium Regulation

Question 1

3 hormones of calcium regualtion

Answer 1

PTH, Calcintonin, Calcitorol

Question 2

name 5 functions of calcium

Answer 2

maintain bone matrix, maintain tight cell junctions, co-factor in coagulation, normal neuron excitability, intracellular signalling

Question 3

where is calcium located in body?

Answer 3

99% bone, 0.9% ECF, 0.1% intracellular

Question 4

when is PTH released and where does it act

Answer 4

released when serum Ca is low. acts on bone, distal kidney and intestine

Question 5

how does calcitonin work?

Answer 5

antagonist of PTH. decrease bone resorption and increase kidney excretion

Question 6

describe the biochemical pathway of vitamin D to D3. describe any points of stimulation

Answer 6

diet or sunlight make give vitamin D>lliver enzymes>kidney enzymes (PTH stimulates)> Calcitrol

Question 7

role of calcitrol?

Answer 7

increase excretion from bone, increase intestinal absorption increase renal reabsorption

Question 8

which regulation paralells that of calcium

Answer 8

phosphate

Question 9

what could cause hypercalcaemia and what is a likely result

Answer 9

hyperparathyroidism (hypersecretion of PTH). can cause osteoporosis