C4 Therapeutic uses Flashcards
1
Q
equation BP
equation CO
A
BP = CO x TPR CO = HR x SV
2
Q
Describe Homeostatic mechanism of BP
A
If decrease in blood pressure = baroreceptor reflex = sympathetic nerve activity Increases HR Increases TPR Increases blood pressure
3
Q
Describe B2 as a potential treatment for parkinsons disease
A
Increase α-synuclein implicated in PD
β2 stimulation = decrease α-synuclein transcription
Salbutamol (crosses BBB) associated w/ decrease risk of developing PD
β2 antagonist correlated w/ increased risk
4
Q
name some uses of B-antagonist
A
Class II antidysrhythmic Antianginal Glaucoma Migraines Anxiety
5
Q
b3-adrenoceptors – location & function
A
Receptors on surface of cells & tissues Adipose - lipolysis, thermogenesis Skeletal muscle - thermogenesis Smooth muscle - relaxation CNS - anti-stress Heart - reduced contractility
