C1 Adrenoreceptors

Question 1

Name some drugs which act on adrenoceptors

Answer 1

Propranolol & Atenolol :(antihypertensive/ antanginal)
Bisoprolol (antihypertensive)
Prazosin (antihypertensive)
Salbutamol & salmeterol (antiasthmatic)
Doxazosin & Tamsulosin (Benign prostatic hypertrophy)

Question 2

Name the adrenoreceptors and their subtypes

Answer 2

a-adrenoceptors: a1A, a1B, a1D + a2A, a2B, a2C

B-adrenoceptors: B1, B2 & B3

Question 3

how are receptors best characterized pharmacologically?

Answer 3

using antagonists e.g.
ALPHA: Ergotoxine, Phentolamine, Phenoxybenzamine
BETA: Propranolol

Question 4

what agonists allowed identification of a2 adrenoreceptors

Answer 4

yohimbine, clonidine

Question 5

where does NA active adreno-subtypes synoptically?

Answer 5

NA activates a1 postsynaptically & a2 presynapticcally

Question 6

what did study on B3 adrenoreceptors show

Answer 6

showed B3 binding to sympathetic nerves lead to non-shivering thermogenesis