C2 Structure

Question 1

what G protein coupled signaling results from what adrenoreceptors

Answer 1

a1 = Gq 
a2 = Gi/Go 
B1/B2/B3 = Gs

Question 2

describe the events of B1 binding to cardiac muscle

Answer 2

B1 activate via Gs.
B1 –> adenylyl cyclase –> cAMP –> PKA
= In Ca influx = In force of contraction

Question 3

describes events of B2binding to Smooth muscle

Answer 3

B2 activate via Gs.
B2 –> adenylyl cyclase –> cAMP –> PKA
= phosphorylation MLCK = Relaxation

Question 4

describe the activation process of NA binding to a2

Answer 4

activates Gi/o: Ca influx –> smooth muscle contraction

Question 5

describe the activation process of NA binding to a1

Answer 5

activates Gq –> PLC: PIP2 –> IP3 + DAG

IP3 = Ca efflux from ER & DAG –> PKC = smooth muscle contraction

Question 6

name possible modifications of NA

Answer 6

removing OH –> dopamine (little activity @ adreno) = BetaOH essential
adding CH3 –> a-meNA: Increases selectivity & decreases potency @ a2
2y amines: Adr & Isoprenaline: Increases bulk amine substituent = decrease alpha activity/ Increase Beta activity.