A4 druggable targets

Question 1

Drugs can affect what processes? (8)

Answer 1

a: affect storage in vesicles
b: cause leakage of transmitters
c: block/activate ion channels
d: inhibit synthesis
e: block reuptake
f: block enzymatic degradation
g: bind to receptors
h: affect second messenger signaling

Question 2

Define false transmitters

Answer 2

compounds taken up by the biosynthetic pathway & incorporated into synaptic vesicles & forms a false transmitter

Question 3

Define Monoamine oxidases:

Answer 3

Reduce levels of free neurotransmitters w/in cellular compartment & protect against dietary monoamines
(Preventing breakdown = increased conc of neurotransmitters w/in synapse)

Lots of antidepressants act on MAO-A,
MAO-B Parkinson’s

Question 4

sympathomimetics are what type of agonists?

Answer 4

Indirectly acting