C/B Exam 2 Flashcards

1
Q

What did Myers and Sperry do and what did they find

A

severed the hemispheres of cats and monkeys

Found: corpus callosum is the PRIMARY COMMUNICATION HIGHWAY
-also have bilateral structures and homotopic areas

-cats and monkeys 70% of their callosal axons during development

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2
Q

Copus callosum has been severed in ___ patients

A

split-brain

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3
Q

what is the wada test

A

anesthetize ipsilateral hemisphere

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4
Q

what happens if you anesthetize LSH

A

-ability to speak is impaired

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5
Q

LSH functions

A

-language
-detail oriented

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6
Q

RSH functions

A

-face recognitions
-emotional prosody (understanding emotions)
-holistic (big-pictured) focused

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7
Q

LH protrudes in the ___ of the brain

A

back

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8
Q

RH protrudes in the ___ and is chubbier in the brain

A

front

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9
Q

connecting same structures

A

homotopic

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10
Q

connecting different structures

A

heterotopic

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11
Q

-smaller than corpus callosum
-connects temporal lobes areas (amygdala)
-posterior commissure (even smaller)

A

Anterior commissure

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12
Q

ability to communicate solely to one hemisphere is based on the anatomy of the ____

A

optic nerve

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13
Q

at the ___ the optic nerve divides in half and the fibers that carry the visual info from the ____ portion of each retina cross and project to the visual cortex of the opposite hemisphere, while the fibers that carry visual info from the ___ portion of the retinal continue onto the visual cortex of the ipsilateral hemisphere

A

optic chiasma, medial, lateral

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14
Q

in tests of the split-brain patients, experiments restrict visual stimulus to a single ___

A

hemisphere

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15
Q

when 1 hemisphere initiates behavior that the other hemisphere detects externally giving it a cue about the answer to a test; not intentional

A

cross cuing

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16
Q

ability to understand that other individuals have thought, beliefs, and desires (that may differ from your own)

A

theory of mind

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17
Q

theory of mind critical structures

A

temporal-parietal junctions (TPJ) in the RH
-both hemispheres are engaged
–mPFC amygdala-temporopolar cortex
–pSTS, precuneus

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18
Q

if info about ___ is housed in the RH and isn’t transferred to the speaking LH you might expect impairments in social and moral reasoning

A

belief attribution

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19
Q

people who have an intact corpus callosum say what about belief attribution

A

say it was moral they realize Grace had a false belief

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20
Q

people who have a severed corpus callosum say what about belief attribution

A

say it was morally unacceptable but were often uncomfortable with their answer and tried to justify it

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21
Q

Why is there a difference in moral judgment in severed corpus callosum

A

-when the LH gives its answers locally, the RH hears the judgment for the first time
-RH’s emotional reaction to the judgment may be surprise and dismay

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22
Q

following a colostomy, what skills remain intact in the LH

A

-verbal intelligence and problem solving skills

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23
Q

causal inferences and interpretations are a ____ specialization

A

LH

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24
Q

LH never admits ignorance about RH, always makes up a __

A

story

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25
Q

does callosotomy prevent emotional info from transferring

A

no, emotional info transferred subcortically

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26
Q

LH’s interpreting nature can contribute to ______

A

false memory

-RH and LH can detect familiar stimuli and new unrelated stimuli but LH tends to detect false positives when new stimuli are related

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27
Q

_____ in the RH can also function as an interpreter

A

illusory contours

-to perceive objects in the environments as unified, one must often extrapolate incomplete info

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28
Q

face perception involved what regions

A

-fusiform gyrus (right-lateralized, ventral occipitotemporal cortical –VOTC– recognition network)
-FFA (fusiform face area)

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29
Q

face is processed

A

holistically

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30
Q

perception and recognition are better for faces presented upright than inverted

A

face inversion effect

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31
Q

where it becomes more difficult to detect local feature changes in an upside-down face, despite identical changes being obvious in an upright face

A

thatcher effect

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32
Q

inversion impairs the processing of faces more than the processing of than the processing of non-facial objects ex. buildings or cars

A

face-object effect

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33
Q

humans may be the only species to naturally use the face as the ____ source of info for individuation

A

primary

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34
Q

-young children process faces in a piecemeal fashion such as eyes, nose, mouth
-holistic processing begins around the age of 10

A

encoding switch hypothesis

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35
Q

what is the dominant theory regarding the processing

A

holistic processing — could even precede the development of part-based processing

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36
Q

rare condition where one can’t recognize faces including their own, familiar, and famous people

A

prosopagnosia

-most cases acquired through brain damage
-deficit it both ANTEREOGRAFE AND RETROGRADE
-possibly through genetic mutation as well

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37
Q

prosopagnosia is a ___ to match sensory input to representations

A

failure

-due to are facial preception areas being damaged

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38
Q

face perception emerges from ____ and ___

A

sensory input & recognition

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39
Q

when the top half of one face is aligned with the bottom half of another and presented upright, the resulting composite arrangement induces a compelling percept of a novel facial recognition
**more easily illustrated in studies that use unfamiliar face stimuli compared to familiar

A

composite face illusion

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40
Q

Pathway of the visual system

A

Light passes through lends - inverted and focused to project on retina –> Optic nerve –> Optic chiasm –> Thalamus –> Primary auditory cortex –> secondary visual cortex

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41
Q

When do receptor cells become active?

A

when the stimulus exceeds a minimum intensity level (meets the threshold)

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42
Q

Adjustment of the sensory system’s sensitivity to the current environment and to changes in the environment

A

Adaptation

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43
Q

How well we can distinguish among stimuli within a sensory modality
ex. telling difference btw hz or smells of fruits = acuity

A

acuity

-distinguish by:
-stimulus collection system design
-number and distribution receptors

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44
Q

-best in the center of our visual field
-central region of retina is packed with photoreceptors

A

Visual acuity

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45
Q

rapid eye movement between fixed eyes

A

Saccades

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46
Q

What does squinting do?

A

-Makes the pupil smaller which results in better focus
- limits the amount of light that enters the eye

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47
Q

If a sensory system devotes more receptors to certain types of information…

A

corresponding increase in cortical representation

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48
Q

Benefits of increase in the cortex:

A

-flexible behavior
-memory capacity
-action and attention
-links many systems

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49
Q

Thalamic connections has:

A
  • many subdivisions
    -reciprocal connections with primary cortices
    Intra (within) thalamic connections
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50
Q

2 or more senses coming together and working

A

Multi-sensory integration

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51
Q

when 2 senses collide with one another and lead to misconceptions *

A

McGurk Effect

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52
Q

Flow of information - audition

A

1.Sound waves enter auditory canal
2.sound waves get amplified
3. waves hit the tympanic membrane making it vibrate
4. vibrations travel through middle ear and rattle the malleus, incus, and stapes
5. vibrations are sensed by tiny hair cells along basilar membrane of the fluid filled cochlea

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53
Q

does the visual system override the auditory system?

A

yes

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54
Q

Typanic membrane is the

A

eardrum

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55
Q

what are the small bone in the middle of the ear

A

malleus, incus, and stapes

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56
Q

hair cells in the ear

A

stereocilia

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57
Q

what determines frequency tuning

A

location of hair cell on the membrane

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58
Q

Spatial arrangement is called ___ which forms a ____

A

tonotopy

tonotopic map

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59
Q

What do hair cells act as

A

mechanoreceptors - mechanically gated ion channels allow K+ and Ca2+ to flow in

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60
Q

Loss of hair cells leads to

A

deafness

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61
Q

Speech and music

A

-made of complex frequencies activating a broad range of cells
-important for human communication

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62
Q

Subdivision of information in the brain

A

-primary & secondary areas
-rostral A1 (low frequency)
-caudal A1 (high frequency)
-tuning curves become narrow in the cortex
**Cells response to narrower frequencies of sound

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63
Q

Discrimination of sound

A

-sharp acuity in humans
- goal = localize sound
- interaural time

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64
Q

where do the auditory nerve project to?

A

cochlear nuclei
-CN in the medulla
-each auditory nerve fiber splits to synapse in both the dorsal and ventral cochlear nuclei

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65
Q

info travels up to the pons and splits to innervate ______

A

L & R superior olivary nuclei
-info from both ears is shared here

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66
Q

projects to the medial geniculate nucleus in the

A

thalamus

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67
Q

after the medial geniculate nucleus, it then goes to the primary auditory cortex in the ____ lobe

A

temporal

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68
Q

the difference in when sound reaches each ear

A

Interaural time

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69
Q

auditory cortex can dissect components of sound and integrate then into an entire experience

A

Music

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70
Q

What kind of processing is feature extraction

A

bottom up

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71
Q

what kind of processing is feature integration

A

top down

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72
Q

Components of music

A

pitch, rhythm, tempo, beat, meter, contour, loudness etc.

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73
Q

distinguished instruments (tonal color) & describes the way a single instrument can change sound as it moves across its range

A

Timbre

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74
Q

the brain represents it directly

A

Pitch and the brain

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75
Q

Tapping along, keeping time

A

cerebellum

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76
Q

performing music and planning

A

motor cortex and frontal lobes

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77
Q

tactile feedback you’ve pressed the correct key

A

somatosensory cortex

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78
Q

audio feedback you’ve pressed the correct key

A

auditory cortex

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79
Q

reading music

A

visual cortex

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80
Q

recalling lyrics

A

language areas

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81
Q

emotional experience

A

amygdala, NAC, and VTA

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82
Q

orienting experience

A

anterior cingulate cortex, hippocampus, and PFC

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83
Q

distinguishing timbre

A

superior temporal sulcus

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84
Q

Temporal lobe epilepsy

A

musical hallucinations

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85
Q

Why do we get chills sometimes when we listen to music?

A

The autonomic fear-based response gets activated

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86
Q

The autonomic system cannot be shut down - cognitive interpretation in the cortex can inhibit the fear and allow us to experience pleasure bc we know its not dangerous

A

David Huron’s theory

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87
Q

a cultural practice that leads to a lasting genetic change

A

Gene-culture coevolution

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88
Q

Do tamarins and marmosets prefer silence or music

A

silence

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89
Q

What indicated that humans and chimpanzee share evolutionary history in context of music

A

both prefer music of silence

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90
Q

-visual and somatosensory information gets distorted
-we know less about smells and taste
-sounds seem to stay coherent

A

Auditory perception in dreams

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91
Q

perceiving info at a distance

A

remote sensing (exteroceptive perception)

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92
Q

light passes through the ___ of the eye

A

lens

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93
Q

image is inverted and focused to project onto the ___

A

retina

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94
Q

what are the densely packed layers of neurons

A

retina

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95
Q

the deepest retinal layer is composed of ___ containing ___

A

photoreceptors; photopigments

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96
Q

low light; evenly distributed and active at night

A

rods

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97
Q

color- densely packed near the center (FOVEA), active during the day

A

Cones

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98
Q

responds to short wavelengths (blue part of the spectrum)

A

short cones

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99
Q

responds to medium wavelengths (greenish part)

A

medium cones

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99
Q

responds to long wavelengths (reddish)

A

long cones

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100
Q

light-sensitive proteins

A

photopigments

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101
Q

low light contrasts — found in rods

-when exposed to light, proteins split apart
- destabilization alters membrane potential of the photoreceptors
- triggers AP in downstream neurons - transduction

A

rhodopsin

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102
Q

color vision - found in cones

A

photopsin

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103
Q

connected to BIPOLAR NEURONS that synapse with GANGLION CELLS

-info is compressed

A

rods and cones

104
Q

ganglion axons bundle to form ___

A

optic nerve

105
Q

cross-over of info occurs at the

A

optic chiasm

106
Q

90% of axons in the optic nerve are involved in ____ pathway

A

retinogeniculate

107
Q

what is the retinogeniculate pathway

A

retina –> optic nerve –> optic chiasma –> thalamus

108
Q

what is the geniculocortical pathway

A

thalamus —> primary visual cortex –> secondary visual cortex

109
Q

the region within the visual field in which stimulation affects neuron’s response

A

the receptive field of a neuron

110
Q

receptive visual fields form ___

A

topographical (retinotopic) maps

111
Q

on-of edge detectors in V1
-receptive fields are circular with on-off regions
-when the cell is active, not only indicates position of stimulus but also retention of stimulus edge

A

fussy cells

112
Q

-cells in the retina and LGN respond best to small spots of light
-cells in V1 are sensitive to edges
-V4 & TE optimal stimulus becomes more complex ex. shapes or faces

A

visual areas

113
Q

-LGN receptive field -a very limited region of space, less than 1 degree of visual angle
-cells in V1 – slightly larger receptive fields ranging up 2 degrees
-magnification process continues through the visual system

A

receptive fields become larger across visual system

114
Q

-don’t respond to color
-responds to movement and direction
-this cell responds preferentially to down and left
-responds maximally when the stimulus is moved quickly
-stimulus must be in the receptive field

A

MT (V5) cells

115
Q

genetic- recessive gene on x-chromosome –> higher prevalence in males

A

color blindness

116
Q

3 cones working together to determine what color you’re looking at; not colorblind

A

trichromacy

117
Q

all 3 photopigments are present but one exhibits abnormal sensitivity

A

anomalous trichromats

118
Q

-pretanomalu (L cone is impair)
-Deuteranomay (M cone is impaired)

A

red green colorblindness

119
Q

trianomaly (s cone impaired)

A

blue yellow colorblindness

120
Q

-individuals with only 2 photopigments (protanopia, deuteranopia, tritanopia)

A

dichromats

121
Q

missing photopigments sensitive to either medium or long wavelengths

A

dichromats red green

122
Q

missing photopigments sensitive to short wavelength (very rare)

A

dichromats blue yellow

123
Q

-involves a lesion to V4
-decreased acuity
-partial or total absence of color vision
-may be uncomfortable in bright environments

A

achromatopsia

124
Q

loss of motion detection, view the world as a series of snapshots

A

akinetopisa

125
Q

-perception is a synthetic process
-coherent representation
-coherence sometimes involves distorting the sensory info to make it all make sense

A

multimodal perception

126
Q

-multimodal site
-topographical maps of visual, auditory, and tactile info
-contains cells that respond more when presented with multimodal stimuli
-spatial and temporal coincidence detection for integration

A

superior colliculus

127
Q

-projection to and form sensory cortices
-responses to visual, auditory, and somatosensory stimuli
-active in lop reading when sound matches the movement

A

superior temporal sulcus (STS)

128
Q

-audiovisual (somatosensory integration)
-theory of mind – mentalization
-motion perception
-speech processing
-processing faces
-propose that the function of the STS varies depending on the nature of network coactivations with different regions in the frontal cortex and medial-temporal lobe
-keeping with the notion that the same brain region can support different cognitive operations depending on task-dependent network connections, emphasizing the role of network connectivity

A

the chameleon of the brain

129
Q

auditory and visual stimuli can enhance ____ in the other sensory modality

A

perception

-TMS over visual cortex – increased response time to the auditory cortex
-TMS at the subthreshold level – phosphenes were only visible when auditory stimulus were presented

130
Q

when were phosphenes visible

A

when auditory stimulus were presented

131
Q

when senses are mixed

A

synesthesia

-most common form is grapheme-color/or colored sequence (better at color discrimination)
-aberrant cross-activation of one cortical area by another
-hyperactive sensory system – one hypothesis
-visual processing areas may be organized in a more distributed way – not confined to the visual cortex
-potentially more white matter

132
Q

deaf individusals show activation in the auditory cortex in response tp ___ and ___ stimuli

A

tactile and visual

133
Q

there is an increase in ___ ___ volume in deaf people with enhanced visual perception

A

planum temporale

134
Q

cross-modal plasticity only occurs when disability is ____

A

congential

135
Q

what brain regions are involved in moments of insight

A

-right superior temporal gyrus
-right parietal cortex

-(right parietal lesion –> loss of artistic sense)

136
Q

a burst of activity seen just prior to the creative insight suggests what?

A

some level of unconscious info-integrating processing

137
Q

what brain regions are involved in math problem solving

A

-frontal. right temporal, and parietal lobes

138
Q

what brain region is involved in impulse control

A

DLPFC

139
Q

what happened when jazz musicians improvise

A

deactivation of DLPFC

140
Q

-dyslexic (impairment in LH)
-prosopagnosia (impairment in RH)
-adept at drawing
-portrait artist
-left-handed (RH dominant)

A

chuck close

141
Q

damage to what hemisphere can enhance creativity

A

LH

142
Q

-“mental time travel” – future thinking
-autonoetic consciousness
-distinction btw episodic and semantic memory

A

endel tulving

143
Q

acquisition/encoding

A

learning

144
Q

retrieval/recall

A

memory

145
Q

new info enters the brain along pathways btw neurons in the appropriate area of the brain. Here attention pay the key role in receiving and encoding the info

-sensory info comes in being filtered, some info will go onto STM or LTM

A

acquisition

146
Q

if you pay attention well enough to encode new info in your brain, you brain sends signals to store the info as long-term mem. It is more easy to retain info if it is related to something you already know or if it stimulates an emotional response

-stabilization of memory traces via placisticy
-how mems go from STM–> LTM
-occurs at the cellular level (protein synthesis dependent, synaptic consolidation)

A

consolidation

147
Q

recalling info, your brain has to activate the same pattern of cells it used to store it. The more frequently you work the info the easier it is to retrieve it

A

retrieval

148
Q

Sensory memory for auditory info

A

echoic mem

149
Q

Sensory memory for visual info

A

iconic memory

150
Q

a small amount of info that can be held in mind and used in the execution of cognitive tasks
-contents can be obtained from sensory memory from LTM
*distributed across the cortex
*Research shows that oscillatory synchrony of these areas may underlie __

A

WM

151
Q

What is the main difference between STM and WM

A

WM is used in cognitive tasks and does not involve the hippocampus

152
Q

What do both STM and WM activate?

A

prefrontal, cingulate, parietal, sensory cortices, and basal ganglia and thalamus

153
Q

-involves WM
-individuals w shizo have impairments with this task
-measures many things including attention and visual processing

A

Wisconsin Card Sorting Test

154
Q

What did the WCST Test determine

A

that there is a PFC deficit in schizophrenia

155
Q

Sensory inputs –> sensory registry + w/ attention –> short term storage + rehearsal –> long term storage
- info can be lost by decay or interference

A

Atkinson and Shriffin Modal Model of Memory

155
Q

Damage to left perisylvian cortex - showed impairments in STM using digit span test.
- able to form LT associative memories w a word text
- shows dissociation between STM and LTM
-STM MAY NOT BE REQUIRED TO FORM LTM

A

Patient K.F

156
Q

-Damage to left angular gyrus
- deficit in STM but preservation of LTM
- info may be encoded directly into LTM from sensory memory registers

*double disassociation

A

Patient E.E

157
Q

-central executive mechanism that presides over coordinate interactions b/n 2 subordinate STM stores and LTM
- phonological loop and visiospatial “sketch pad”

A

Baddeley and Hitch WM Model

158
Q

acoustic code - recall of words better when they dont sound similar (interference)
-suggests that WM uses acoustic code rather than semantic code

A

Phonological loop

158
Q

acoustic code - recall of words better when they dont sound similar (interference)
-suggests that WM uses acoustic code rather than semantic code

A

Phonological loop

159
Q

people perform better when instructed to use visual imagery to remember a list compared to a verbal memory strategy
- if verbal interference introduced - impaired in using this strategy

A

Visiospatial “sketch pad”

160
Q

(left supramarginal gyrus)
- have deficits in phonological working memory
-can’t hold strings of words in WM

A

Lesion in Brodmann area 40

161
Q

what part of the brain involves the phonological loop

A

-left premotor area (brodmann area 44)
-lateral frontal
-inferior parietal lobes

162
Q

How is WM maintained?

A

rhythmic synchrony of brain oscillations
-Sustained representations

163
Q

WM = not as persistent in spiking

A

Sustained representations

164
Q

Why does WM have a limited capacity?

A

With too much activity there can be interference. Limited because of the coding scheme

165
Q

spikes “refresh the memory”

-memories held by persistent spiking alone can be liable because they are lost when activity is disrupted
*models of persistent spiking have trouble holding more than one memory at a time

A

activity silent models

166
Q

as WM capacity is exceeded the less neural activity there is –> spreading too thin

A

resource model

167
Q

only so many slots, phenomenon is all or none – stimulus is encoded (remembered) or not, no partial info is acquired as u see in the resource model

A

slot model

168
Q

___ requires less space in in WM

A

chucking

169
Q

impairments in the ability to CONTROL contents of WM
-impairments in this ability can results in ___ ex. anxiety, schizo

A

pathology

170
Q

info retained for significant amount of time
-divided into declarative and non-declarative

A

LTM

171
Q

aka explicit memory; memory for events and facts, both personal and general to which we have conscious access and can verbally report it

A

declarative mem

172
Q

endel tulving proposed declarative mem be parsed into ___ and __ mem

A

episodic and semantic

173
Q

comprises memories of events that the person has experienced that include contextual elements ex. what happened, where it happened, when and with whom
*EXPERIENCE

A

episodic

174
Q

memory that pertains to yourself and can be episodic or semantic

A

autobiographical mem

175
Q

objective and factual knowledge

A

semantic mem

176
Q

-cannot be expressed verbally -don’t have conscious access
-aka implicit mem

ex. priming, conditioning, habituation, sensitization, and procedural mem

A

non-declarative mem

177
Q

-motor skills
-cognitive skills such as reading
-ability to form habits
-depends on extensive and repeated experience

A

procedural mem

178
Q

procedural mem relies on ____-____ ganglia loops

A

cortical-basal

179
Q

exposure to one stimulus (priming stimulus) subconsciously influences a response to a subsequent sequence (target sequence

-acts within the PERCEPTUAL REPRESENTATION SYSTEM: specific for sensory modality of the learning and test phases

-medial temporal independent

A

priming effect

180
Q

based on the meaning of a stimulus and is enhanced by semantic tasks. For example, the word table will show ___ priming effects on the word chair, because the words belong to the same category

not consciously aware of it

A

conceptual priming

181
Q

prime and target are different words from the same semantic category

ex. dog and wolf

A

semantic category

182
Q

Conditioning an individual to respond to a certain US

A

Classical conditioning

183
Q

CS and US overlap, CS starting first and both ending at the same time

A

Delay conditioning

184
Q

CS precedes YS
- Gap between when CS ends, and US presentation begins

A

Trace conditioning

185
Q

Delay is HPC ___ and trace is HPC ____

A

independent; dependent

186
Q

diminishing of a physiological response to a repeated stimulus

A

Habituation

186
Q

used to study fear related behaviors

A

Fear conditioning

187
Q

-developed a novel theory for sensory habituation

-propose that memory engrams for habituation experience may be ensembles for inhibitory neurons forming to provide a “negative image” of the excitatory ensembles that mediate the perception of environmental stimuli

A

Cooke and Ramaswami

188
Q
  • if the stimulus is withheld, the response tends to recover over time (spontaneous recovery)

-the weaker the stimulus, the more rapid and/or more pronounces is habituation - strong stimulation may yield no significant habituation

-habituation to a given stimulus exhibits stimulus generalization to other stimuli

-presentation of another (usually strong) stimulus results in a recovery of the habituated response (dishabituation)

-habituation is gated - occurs less efficiently if reward, punishment, or strong emotional engagement occurs together with stimulus exposure

-long term habitation requires de novo protein synthesis

A

Characteristics about habituation

189
Q

enhancement of a physiological response to a repeated stimulus - the organism becomes more responsive to the same stimulus

A

Sensitization

190
Q

a tactile stimulus applies to the siphon elicits a gill ______ reflex

A

withdrawal

191
Q

processing of incoming info which creates MEMORY TRACES or “ENGRAMS” via biochemical changes synaptic strength and connections
-2 step process – gazzaniga

A

encoding

192
Q

retention (preservation) of memory traces, opp. of decay

A

storage

193
Q

successfully accessing memory traces for use; drives decision making and behavior

A

retrieval

194
Q

what are the two findings that claim memories are consolidated

A

(1) brain trauma - patient H.M; post traumatic amnesia
(2) Resection of the hippocampus caused anterograde and retrograde amnesia

195
Q

inability to remember the past (damage to cellular networks holding those memories)

A

Retrograde amnesia

196
Q

inability to form new memories (cells not getting enough oxygen/processing like encoding & attention affected/impaired sleep)

A

Anterograde amnesia

197
Q

i. hit his head at 7
ii. seizures at 10
iii. hippocampus removed at 27
retrograde 16 - 27
anterograde 27 - death

A

Patient H.M

198
Q

oldest memories survive the best

A

Ribot’s Law

199
Q

the process by which the hippocampus guides the reorganization of the info stores in the neocortex such that it eventually becomes independent of the hippocampus

A

system consolidation

200
Q

What part of brain is important for working memory?

A

parietal and frontal cortex

201
Q

Neurosurgeon who performed bilateral hippocampal resection surgery on H.M (remove only one HPC today if needed)

A

William Scoville

202
Q

neurosurgeon known for his work on the cortical homonculus, hallucinations, & deja vu

A

Wilder Penfield

203
Q

neurons fire at random –> results in false sense of experiencing familiar situation that had previously been experiences

A

Deja vu

204
Q

primary student who studied H.M after his surgery

A

Brenda Milner

205
Q

What is the assumption of systems consolidation

A

new memories require the HPC - however old memories don’t depend on the HPC which is why they are preserved

206
Q

process by which HPC guided reorganization of info stored in the neocortex such that it eventually becomes individual of the HPC

(standard model)

A

system consolidation theory

207
Q

organized group of past experiences –> like an archetype or motif

A

schema

208
Q

old memories still depend on the HPC but are more resistant to disruption because they have more opportunity to be reactivated

-each reactivation generates another index in the HPC and because these copies are distributed, even in cortical areas, the memory can survive partial damage

A

multiple trace theory

209
Q

-representational reinstatements of an episodic memory trace upon receiving only a partial cue
-generating an entire memory from only part of the memory trace (i’ve seen this before)

-CA3– recurrent collaterals

A

pattern completion

210
Q

-representational orthogonalization (separation) of episodic memory traces upon highly similar inputs (leading to a high degree of mnemonic discrimination for similar events)
-the ability to store and disambiguate events that are highly similar by using a code in the brain where the cells that correspond to those events are memory traces that are completely unique
-dentate gyrus
-_____ ____ relies on sparse coding scheme in the DG compared to cortex involving low basal activity, a high degree of inhibition, and millions of neurons

A

pattern separation

211
Q

loop - first describe by Cajal using Golgi staining method

A

Tri synaptic circuit

212
Q

granule cells in the__

A

DG

213
Q

mossy cells

A

parametal neurons

214
Q

pyramidial neurons in ____

A

CA1/CA3 = Schaffer collaterals

215
Q

EC –> DG

A

perforant path

216
Q

DG –> CA3

A

mossy fibers

217
Q

the phenomenon where adults have difficulty recalling memories of early childhood

A

Infantile amnesia

218
Q

developed his theory based on the observation that his adult patients rarely recalled memories of their first years of life (before 6-8 years)

A

Freud & infantile amnesia

219
Q

absence of memories

A

Age 0-3 memories

220
Q

spotty recall of memories

A

age 3-6

221
Q

When does memory begin to develop

A

24-36 months of age

222
Q

cortex is not “online”
-Pillemmer and white & Nelson

A

Immature brain

223
Q

-Tulving and Thompson
being in the same state to remember a specific memory

A

State dependency & memory

224
Q

continuing of neurons forming disrupts established memories
-regulates the ability to form enduring HPC-dependent memories

A

neurogenic hypothesis

225
Q

facilitates the formation of new memories by increasing capacity and reducing interference between old
-ability to block irrelevant information reduces demands when trying to recall important information

A

adaptive forgetting

226
Q

-Highly superior autobiographical memory/hyperthymesia

-inability to forget anything
-an extremely rare condition

A

HSAM

227
Q

exceptional memory - extremely vivid associations of visual imagery.
-made mistakes due to perceptual problems, not a memory lapse

*REMEMBER THINGS SEPARATELY

A

Patient S

228
Q

set of cells involved in memory

A

Engrams

229
Q

-contextual representations and engrams
-searched for the location of a specific engram for a maze environment in the rat brain

A

Karl Lashley

230
Q

Engrams are distributed (____) and cortex works as a whole (___)

A

-equipotentiality
-mass action

231
Q

excitability and engram allocation

A

CREB

232
Q

NEURAL NETWORK THEORY
- memory resides in CELL ASSEMBLIES; synapses can be strengthened or weakened

-strengthening synapses resulted when a weak and a strong input act on a cell simultaneously (coincident detection – associativity/cooperativity)

A

donald hebb

233
Q

stimulating axons of the perforant path resulted in long-term increases in the magnitude of EPSPs – granule cell response was larger with subsequent stimulation

*NEED DEPOLARIZATION TO OCCUR
* increase calcium in cells leads to decrease ___ and hyperpolarization

A

long term potentiation

234
Q

when pulses are presented slowly —> ___

A

LTD

235
Q

Where does LTP occur

A

hippocampal regions (mossy fibers & Schaffer collaterals), amygdala, cerebellum, basal ganglia, and cortex

236
Q

receiving more than one input at the same time

A

Cooperativity

237
Q

weak inputs potentiated when they cooccur with stronger inputs ex. classical conditioning
*cells that fire together wire together

A

Associativity

238
Q

only the stimulated synapse is potentiated
-post-synaptic cells must be depolarized
-if the cell is hyperpolarized, LTP is prevented
-when postsynaptic inhibition is prevented LTP is facilitated
-involves de novo synthesis

A

specificity

239
Q

what must occur for specificity

A

post-synaptic cells must be depolarized
-if the cell is hyperpolarized, LTP is prevented
-when postsynaptic inhibition is prevented LTP is facilitated
-involves de novo synthesis

240
Q

Receptors involved in LTP

A

interactions between glutamate AMPA and NMDA receptors

241
Q

NMDARs vs AMPARs

A

-NMDARs => critical for producing LTP + voltage gated
-AMPARs => maintaining LTP

242
Q

What can happen if you block NMDAR

A

prevent LTP and impair learning

243
Q

certain hippocampal cells firing only when animal is in a specific location

A

Place Cells

244
Q

The geographical location of place cells

A

place fields

245
Q

fire in multiple positions which creates a hexagonal firing pattern
-located in the major HPC input region, the entorhinal cortex

A

Grid Cells

246
Q

neurons increase their firing rate during sleep T or False

A

true

247
Q

re-occurance of sequence of cell activations that also occurred during learning
–>can be in same order or reverse; typically when sleeping
–> thought to be involved in systems consolidation
–> NREM only

A

Hippocampal replay

248
Q

local field potentials are interrupted by short bouts of high frequency

A

Ripples (sleep)

249
Q

sequences of activations that occur before the actual activity in a way that predicts the sequences

A

preplay

250
Q

can we learn while sleeping

A

yes; we can remember the locations of the sounds that were presented during the sleep

251
Q

involves cortisol and norepinephrine (associated with mammalian stress response)

A

Sleep and memory consolidation

252
Q

How can stress affect memory consolidation?

A

it can potentiate memory through reconsolidation which is a period of time where your memories are modifiable when they are reactivated.

253
Q

Chronic stress can lead to…

A

impairments in memory consolidation via high conc. of glucocorticoid receptors in the CA1; atrophy in hippocampal volume; higher risk of Alzheimers

254
Q

-memories can change (experience dependent)
one way is reconsolidation

A

Memory malleability

255
Q

engram –> memory box
-reactivation, destabilization, and reconsolidation

A

Dynamic Memory Engram Life Cycle