Buzzwords Flashcards
Third person auditory hallucinations
Schizophrenia
Mesocortical dopamine hypoactivity
Negative and cognitive symptoms in schizophrenia
Subcortical dopamine hyperactivity
Psychosis
What are the dopamine pathways in the brain?
Tuberoinfundibular, nigrostriatal, subcortical and mesocortical
Tuberoinfundibular is concerned with
Prolactin
Nigrostriatal controls the
Extrapyramidal motor movements
Mesolimbic pathway is concerned with
Motivation and reward
What dopamine pathway is dysregulated in schizophrenia?
Mesolimbic
Mesolimbic Da blockade vs agonism
Depression
Psychosis
What atypical anti-psychotics causes the most weight gain?
Olazapine
Clozapine side effects
Agranulocytosis
Weight gain
How often do you monitor clozapine?
Once a week for first 6 months, once every 2 weeks for next 6, every 4 weeks after and every month after discontinuation
Brain changes in schizophrenia
Reduced frontal lobe volume, enlarged ventricles, reduced grey matter in temporal cortex
Pressure of thought is seen in
Mania and schizophrenia
Poverty of thought means that the patient reports
Lack/absence of thoughts