Buzzwords Flashcards
Third person auditory hallucinations
Schizophrenia
Mesocortical dopamine hypoactivity
Negative and cognitive symptoms in schizophrenia
Subcortical dopamine hyperactivity
Psychosis
What are the dopamine pathways in the brain?
Tuberoinfundibular, nigrostriatal, subcortical and mesocortical
Tuberoinfundibular is concerned with
Prolactin
Nigrostriatal controls the
Extrapyramidal motor movements
Mesolimbic pathway is concerned with
Motivation and reward
What dopamine pathway is dysregulated in schizophrenia?
Mesolimbic
Mesolimbic Da blockade vs agonism
Depression
Psychosis
What atypical anti-psychotics causes the most weight gain?
Olazapine
Clozapine side effects
Agranulocytosis
Weight gain
How often do you monitor clozapine?
Once a week for first 6 months, once every 2 weeks for next 6, every 4 weeks after and every month after discontinuation
Brain changes in schizophrenia
Reduced frontal lobe volume, enlarged ventricles, reduced grey matter in temporal cortex
Pressure of thought is seen in
Mania and schizophrenia
Poverty of thought means that the patient reports
Lack/absence of thoughts
Thought blocking is what?
Abrupt and complete interruption of stream
Thought blocking is associated with
Schizophrenia
What do you treat EPSE with ?
Procyclidine
Flight of ideas vs Knight’s move
Flight of ideas - link
Knight’s move - no link
Amygdala is involved in
Normal response to threat
What does the PFC do?
Dampen downs amygdala response to threat
Management of OCD?
SSRI, SSRI, TCA or SSRI, SSRI or TCA (chlomipramine)
Beck’s triad of psych
-ve feelings about self, world, and future
NMDA antagonists produce
Psychotic symptoms
What do you use in alcohol withdrawal ?
Chlordiazepoxide
Alcohol withdrawal seizures within ____ hours
48
Delirium tremes between ___ and ___ hours
48, 72
Eosinophilic inclusions
Lewy bodies
