Brucellosis Flashcards
Brucella morphology
Gram negative cocco-bacilli
intracellular
Brucella species and disease in animal 4
1-burcella abortus – cattle bison
2-Brucella melitensis – sheep, goats , camels
In saudi
3-brucells suis –swine , reinderrs ,pigs
4-brucella canis – dogs,foxes,coyotes
Transmission 3
Ingestion of milk and diary product (unpasteurized )
inhalation
direct contat on skin wonds
Population at risk of brucella 3
Slaughter house , lab workers , vet
Pathogenesis of brucella 4
Multiplies within phagocytes
Phagocyte transport bacteria to target oragn
in chronic stage it will cause granuloma
severity depend on species
clinical picture of brucella
Acute
prolonged incubation
initial presention is flu like symptoms
weight loss
ChronicIntermittent fever(undulant fever) –>causes rising in afternoon and falling at night. fevers, sweats, malaise, weakness, anorexia, headache, myalgia (muscle pain) and back pain
-generalized lymphadenopathy
-arthritis
-gi trct and repiratory tract symptom
-orchitits
-endocarditits
-abortin
cuatenous manifestation
What happen to a pregnent woman who is infected with brucella 6
Low birth weight
Failure to thrive
Jaundine
hepatosplenomegaly
sepsis (fever , vomting )
respiratory diffculty
What is the most important thing to diagnosse brucella
history of exposure
What to use in for lab diagnosis
Culture
Serologic
Culture characteristics (mostly blood agar )
aerobe
medium - Trypitcase soy agar with selective agent (polymyxin , cyclohexamide)
Small moist glisteing after 4 day of incubation
castaneda’s biphasic medium
Serological diagnoois what do we use
Rose bengal test !!
ELISA
Standard tube agglutination test
Treatment of brucella 3 drugs
Combination therapy : doxycyclie for 6 week in combiantion with streptomycin for 2-3 week or rifampin for 6 week
if its is a CNS case u must treat it for 6-9 months
