Bronchodilators - Muscarinic receptor antagonists

Question 1

Muscarinic antagonists used in respiratory diseases - 2 drugs

Answer 1

Ipratropium

Tiotropium

Question 2

Ipratropium and tiotropium - MOA

Answer 2

Blocks the bronchoconstricting effect of vagus nerve stimulation.

Question 3

Ipratropim and tiotropium - adm

Answer 3

Inhalation for pulmonary disorders.

Nasal spray for rhinitis.

Question 4

Ipratropium compared to β2-agonists in treatment of COPD

Answer 4

Ipratropium has a slower onset of bronchodilation but it lasts longer.

Question 5

Ipratropium - indications

Answer 5

COPD.
Infants with acute bronchitis.
Allergic and viral rhinitis.
Rescue therapy for children with acute severe asthma

Question 6

Ipratropium can be combined with … to treat …

Answer 6

Albuterol - COPD, moderate-severe asthma

Question 7

Tiotropium - indications

Answer 7

COPD - first line

Question 8

Tiotropium - benefits

Answer 8

First once-daily inhaled treatment for COPD.

Question 9

Tiotropium and ipratropium - adverse effects

Answer 9

Dry mouth