Bronchodilators - β2-agonists

Question 1

Bronchodilators - 2 groups + 1 drug and their indications

Answer 1

Selective β2-agonists - acute asthmatic attacks.
Muscarinic antagonists - COPD.
Theophylline - asthma or emphysema.

Question 2

Selective β2-agonists - MOA in asthma

Answer 2

Increase cAMP in smooth muscle and cause muscle relaxation, without causing much cardiac stimulation.

Question 3

Selective β2-agonists - adverse effects

Answer 3

High doses: tachycardia, tremor, nervousness.

Question 4

Rapid-acting β2-agonitst - 5 drugs

Answer 4

Albuterol.
Levalbuterol.
Fenoterol.
Pirbuterol.
Terbutaline.

Question 5

Rapid-acting β2-agonists - indications

Answer 5

Prevent and treat acute bronchospasm

Question 6

Selective β2-agonists - adm

Answer 6

Rapid-acting β2-agonists - inhalation.

Albuterol and terbutaline - also oral (for pts unable to take inhaled drug)

Question 7

Salmeterol and formoterol - indications and classification

Answer 7

LABAs used for long-term treatment of asthma and emphysema.

Nocturnal asthmatic attacks (inhibit late phase).

Question 8

Arformoterol - indications

Answer 8

Chronic bronchitis and emphysema

Question 9

Indacaterol - classification

Answer 9

Ultralong-acting β2-agonist.

Question 10

Indacaterol - indications

Answer 10

COPD.