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Surgery EOR (billie) > breast cancer, disorders of augmented breast > Flashcards

breast cancer, disorders of augmented breast Flashcards

1
Q

what genes are associated with the developement of breast cancer

A

BRCA1
BRCA 2

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1
Q

what are the risk factors for breast cancer

A
  • Nulliparity
  • First full term pregnancy after age 30
  • Early menarche (before age 12)
  • Late natural menopause (after age 50)
  • Postmenopausal combination HRT
  • Hx of uterine cancer
  • Greatest risk factor - personal history of breast cancer
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2
Q

what is the typical presentation of a breast cancer

A
  • painless breast mass
  • Usually hard, fixed, irregular margins, nonmobile
  • MC in upper outer corner!!!

can also see nipple/skin retraction

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3
Q

what are findings that are suggestive of advanced breast cancer

A
  • Marked axillary LAD
  • Supraclavicular or infraclavicular LAD
  • Edema of ipsilateral arm
  • Large primary tumor (>5 cm)
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4
Q

what is the typical presentation of pagets disease

A

pain, itching or burning of breast along with superficial erosion or ulceration

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5
Q

what is the diagnostic of choice for pagets disease

A

full thickness biopsy

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6
Q

what is the treatment of pagets disease

A

mastectomy

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7
Q

what is the presentation of inflammatory carcinomas of the breast

A
  • Diffuse, brawny edema of skin with erysipeloid border
  • “Peau d’orange” (orange peel skin)
  • this is suspected if mastitis does not resolve within 1-2 weeks of ABX usage
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8
Q

what is the treatment of pagets disease

A

surgery, radiation, chemo

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9
Q

what is the reccomendation for recieving screening mammograms?

A

at least once every 2 years among women 50-74

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10
Q

what is the difference between ER/PR/HER2 + and ER/PR/HER2 -

A
  • ER/PR/HER2 +: metastasize to bone, soft tissue, genital organs
    ER/PR/HER2-: metastasize to liver, lung, brain
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11
Q

what is the treatment for ER/PR/HER2 + breast cancer?

A
  • Tamoxifen or Anastrozole
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12
Q

what is the treatment for ER/PR/HER2 - breast cancer?

A

pembrolizumab (Keytruda) + radiation+ chemo

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13
Q

what are the selective estrogen receptor modulators? (SERMs)

A
  • tamoxifen
  • raloxifene
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14
Q

what are the aromatase inhibitors

A
  • anastrazole (Arimidex)
  • exemestane (Aromasin)
  • letrozole (Femara)
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15
Q

what is the follow up regimen for those who recieve treatment for breast cancer

A
  • PE Q 4 mo x 2 yrs, then Q 6 mo x 3 yrs, then yearly
  • Mammogram 6 months after radiation, then yearly
  • Routine laboratory tests
16
Q

which breast cancers have a higher chance of reocurrence

A

receptor negative

17
Q

im not sure what “disorders of augmented breast” is so tbd

A

Surgery EOR (billie) (17 decks)

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