breast cancer Flashcards

1
Q

what’re the most common symptoms of the breast cancer ?

A

its asymptomatic.

pain or discomfort isn’t usually a symptoms of the breast cancer

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2
Q

how to general approach to pt with breast cancer ?

A

by the triple assessment

  • clinical presentation (history)
  • clinical examination
  • imaging
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3
Q

whats the triple assessment ?

A

@history

  • pt with breast cancer is usually with breast cancer is asymptomatic .largrer cancer may don’t have any pain > because the pain and discomfort is not the symptoms of the breast cancer .only 5%-10% of pt with cancer have pain
  • but mainly we search for the the family history of the breast cancer in the 1st degree relative

examine the pt first in siting position and the arm is relax and then exam them in laying position when their arms are raised :

  • check any change in the size and shape
  • any skin changes as tethering or laceration or lesion
  • any nipple inversion , change in the skin changes
  • any nipple discharge
  • any axillary LN changes

after that to complete the examination we should examine the chest , abdomen and the neurology

chest —

a) breathing abnormality
b) bone pain
c) hypercalciemia

abdomen —

a) abdominal pain
b) jaundice

neurology —-

a) headache
b) neurological sign
c) altered cognitive function

 the concerning  findings are : 
1- lump or change in the shape , the size and the counter 
2-skin tethering 
3- laceration 
4-dilated vein 
5-nipple inversion 
6- mammy Paget disease 
7-edema or peau d'Orange 

usually mammography, ultrasound and needle biopsy

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4
Q

what’re the clinical presentation of the breast cancer ?

A

1- painless lump
2- painful lump

3-skin ulceration and fungation
4-nipple discharge

5- axillary lymph nod enlargement
6- secondaries to the liver overies

7- chest pain and heamoptsis
8- bone pain and pathological fracture
9- plural effusion , ascites

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5
Q

what’re the cutaneous manifestation of the breast cancer

A
1- skin ulceration and fungation 
2-ulceration and nipple discharge 
3- nipple retraction 
--------------------------
4-tethering of the skin 
5- dimpling of the skin 
6- peau d' orange 
---------------------------
7- cancer en cuirasse
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6
Q

what’re the concerning findings in the physical examination ?

A
the concerning  findings are : 
1- lump or change in the shape , the size and the counter 
2-skin tethering 
3- laceration 
4-dilated vein 
5-nipple inversion 
6- mammy Paget disease 
7-edema or peau d'Orange
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7
Q

whats the cause of the peau d’ orange ?

A

the dermal lymphatic is obstructed and so the sebaceous gland and the hair follicle is buried تدفن giving raise as orange

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8
Q

whats the cause of the skin dimpling ?

A

cancer vinlterate into the cooper ligament

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9
Q

whats the cause of the nipple retraction as circumferential ?

A

infiltration to the lacterferious duct

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10
Q

whats the cancer en cuirasse ?

A

its that the breast cancer metastasis to the skin and appear nodular as armor coat

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11
Q

what dose the local spread of the tumer means ?

A

its spread to the skin ,pectorals muscle and the chest

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12
Q

what dose the lymphatic spread means ?

A

spread to the internal mammary gland & axilla

in advance stage its spread to the supraclavicaular LN or contalateral side

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13
Q

for where the tumer goes ?

A

it metastasis to the lumber vertebrae ribs and skull

and liver lung and ovary arenal gland

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14
Q

whats non invasive breast carcinoma?

A

ductal carcinoma in situ
lobular carcinoma in situ
paget’s disease

the non invasive only 10%

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15
Q

how the ductal carcinoma is seen in mammogram ? and whats the chance of recurrence ?

A

its seen in the mammogram as microcalcification

after 5 years reccurance (25-50%)

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16
Q

whats the TRT of ductal carcinoma in situ ?

A

1- wide local excision with radiation decrease the recurrence to 2%

2- mastectomy if rise or local and regional recurrence

17
Q

how to detect the lobular carcinoma in situ ? how much the risk to be invasive ?

A

lobular can’t detect in the mammogram but found incidentally
after 20 year of in situ there is 15%-20% to become invasive and it becomes BILATERALLY

18
Q

whats the TRT of pt with lobular carcinoma in situ ?

A
  • flow up

- bilateral mastectomy if there is family history or pervious breast cancer

19
Q

list the invasive breast cancer by percentage ?

A

1- infiltrating ductal carcinoma 75% of all breast cancer
2- infiltrating lobular carcinoma

3 - medullary %5 younger
4- mucinous less than 5%

5- tubular 1-2 %
6- papillary 1-2% elderly more than 60 yrs

7-metablastic 1% in the 6ht decade
8- mammary paget disease 1-4% 6th decade

20
Q

favorable breast carcinoma ?

A

Temon & Pompa

1- tubular
2- medullary —– ocurrance only 2-3%
3- papillary

-survival is 73% and 59%

21
Q

less favorable breast carcinoma ?

A

invasive ductal carcinoma 78%

survival is 38% -54%

22
Q

least favorable breast carcinoma?

A

inflmmatory carcinoma is only 1.5 -3%

23
Q

breast staging ?

A

N—- for lymph node involvement (1-3)

TNM 
#T --- for tumer size from (1-4)
Tx --- tumer size can't assess
T0 --- tumer isn't significance
Tis ---- ductal carcinoma in situ 
             lobular carcinoma in situ 
             paget disease 

T1—— tumer size equal and less than 2 cm
T2 ——— tumer size is greater than 2cm
T3———-tumer size more than 5cm
T4 —- tumer at any size
if tumer extend to the chest or skin
or it was inflammatory breast cancer

Nx —- not assessed
N0— no
N1—- ipsi axillary LN
N2——ipsi axillary LN fixed or matted
ipsi internal mammary LN without axalliary

N3 - ipsi supra or infraclavicular
ipsi internal mammary LN with axillary

Mx – can’t assess
M0 —- no
M1— no metastasis

24
Q

where the breast metastasis ?

A

1- under the breast is muscle and bone

bone 70%
soft tissue 5-15%

2- deep to the Brest to lung and Pleura
is 20%-30%

3- most important organ is liver and the brain
liver 10-12%
brain 2-5%

4- adrenal gland 2-5%

25
Q

what’re the investigations of the breast cancer ?

A
1-mammogram 
2- breast u/s 
3-FNAC
 4-sensual LN biopsy 
 recessional biopsy 
4-CT for chest
6- CT for the abdomen and the brain 
7- chest X ray 
8- x-ray spine 
9- MRI 

10- estrogen and progesterone and her2 receptos
11- tumer marker

12-ductography