Breast Cancer Flashcards
Breast cancer is the ___ leading cause of death.
What cells are affected?
What is key for increased survival?
4th leading cause of death
Epi cells surrounding mammary ducts or lobules
EARLY DETECTION
- increases survival when it’s localized.
Which population tends to have worse outcomes?
African American AFABs
- Diagnosed later
- Worse outcomes
Multifactorial; health disparities
3 Categories of Breast Cancer:
technically only 2…
- Noninvasive (20%): w/in duct
- Invasive (80%): duct + tissue
- Metastasized: bone, liver, lung, brain
5 Types of Breast Cancer:
Which type is non-invasive?
Which isn’t a “true” cancer?
- Ductal Carcinoma in Situ → non-invasive
- Lobular Carcinoma in Situ → not “true” CA
- Infiltrating Ductal Carcinoma
- Inflammatory Breast cancer
- Triple-negative breast cancer
Types of Breast Cancer:
Ductal Carcinoma in Situ
Early, non-invasive breast cancer
About 14-50% of these cases will become invasive if left untreated
Lack Biologic capacity to metastasize
Types of Breast Cancer:
Lobular Carcinoma in Situ
Typical age of diagnosis?
Rare cancer that begins in the lobules
- Not a “true” cancer → CAN’T spread
Increases the chance that breast cancer will develop later
Typically diagnosed at 40-50
Observation?? (don’t know what she meant..)
Types of Breast Cancer:
Infiltrating Ductal Carcinoma
Presentation?
What defining characteristics occur late in disease?
Starts in mammary ducts and epithelial cells lining the ducts then grow into tissue in an irregular pattern.
Presentation:
-Felt as a poorly defined, irregular lump
Late in Disease:
- Fibrosis will develop around lump (dimpling)
- Peau D’Orange due to edema can develop later in disease also
Types of Breast Cancer:
Inflammatory Breast cancer
Diagnosis?
Presentation?
Invasive; Highly aggressive
Typically diagnosed later in disease
May not show up on a mammogram
Presentation:
- No palpable lump
- Redness, Swelling, Pain
Types of Breast Cancer:
Triple-negative breast cancer
What risk factors are associated with this?
What population is at a higher risk of developing this?
Invasive; Highly Aggressive Lacks receptors typical to Breast Cancer - No estrogen receptor - No progesterone receptor - No human epidermal growth factor 21
Risk factors:
BRCA positive + Pre-menopausal
African American Women are at higher risk compared to other races
What % of breast cancer is associated with males?
Issues?
Presentation?
<1%
Diagnosis often delayed → worse outcomes
Presentation:
hard, painless lump; Sub-areolar
With or Without gynecomastia
Breast Cancer + Risk Factors
Non-environmental
- Gender
- 99% AFAB - Age
- 95% of cases >40 yrs - Genetics (BRCA-1 or BRCA-2)
- 1st Degree relative (sister, mom, daughter) - Bone density
- Increased bone density increases risk - Early menstruation or Late menopause
- Atypical hyperplasia
Breast Cancer + Risk Factors
Environmental
- Alcohol
- Obesity
- Hormone Replacement Therapy (HRT)
- Oral Contraceptics w/ Estrogen
- Null Parity
- Radiation exposure
Breast Cancer + Screening
What’s the test?
What age is recommended for screening with no risk factors?
Mammogram
AFAB >40 years for AVERAGE RISK
Breast Cancer + Screening
At what age should screening be done annually?
AFAB >50 years
Breast Cancer + Screening
At what age should screening be done for people with a 1st degree relative with breast cancer or gene mutation?
How often?
Does testing differ?
Screened 10 years before their 1st-degree relative developed breast cancerANNUALLY
Mammogram + MRI (& ultrasound?)
Breast Cancer + Screening
When should Self-Breast exams (SBEs) be done and what’s important to know?
Assess at the same time every month
KNOW YOUR NORMAL
- Some lumps are normal
- Report changes
→ schedule a Provider Breast Exam