Breast Flashcards
what is the most common non-skin malignancy in women and the second most common cause of cancer deaths in the US
breast cancer
which two genes cause 80-90% of breast cancers
BRCA1 and 2
most breast malignancies are what type
adenocarcinoma
what is the most common benign tumor of the breast
fibroadenoma
which breast lesion has a radial scar and grossly resembles carcinoma
complex radial sclerosing lesion
which breast tumor is greek for “leaf-like”
phyllodes tumor
what is PASH
pseudoangiomatous stroma hyperplasia
shows anastomosing slit-like spaces
what is the appearance of ductal carcinoma
firm, pink-gray stellate mass
which condition is Peau D-Orange related to
inflammatory carcinoma
what is the appearance of medullary breast carcinoma
soft, fleshy mass
which type of DCIS causes unilateral erythematous eruption with a scale crust
Paget disease
what is the most common mammary sarcoma
angiosarcoma - often radiation induced
which hormone receptors are involved in 50-65% of breast cancer cases
luminal - ER+, HER2-
according to ASCO, how long should breast biopsies fix
6-72 hours in 10% NBF
what is a Biozorb
breast lesion localization tool - ensures correct locating of lesion
what is an important clinical history grossing consideration of a breast specimen
neoadjuvant therapy
T/F: you do not need to weigh breast reductions
false: it is important to weigh all breast specimens as it can be important for insurance reimbursement
T/F: you should dry specimens before inking
true: this prevents the ink from spreading to areas it doesn’t belong and creating a false margin - pat dry with a paper towel
T/F: if you need to further section a large piece to submit it entirely, you should section through the lesion
false: avoid sectioning through middle of lesion - cut into more pieces if need be
what is the first section to take on a mastectomy case
nipple
how should you section a mammary case of Paget’s disease
amputate the nipple parallel to the skin’s surface
perpendicularly section the nipple
T/F: cut a mastectomy specimen skin up
false: always cut a mastectomy section face down to allow the skin to act as a book spine
which stain can be used on breast lymph nodes to look for metastasis and isolated tumor cells
CK7 (cytokeratin stain)
what is important to note about the staging of invasive breast carcinoma
based on tumor size and involvement of skin/chest wall
