Brain tumors & neurocutaneous disorders Flashcards
pseudopalisading - cells with areas of central necrosis and hemorrhage
gliblastoma multiforme
most common adult brain tumors
MGM Studios Metastasis Glioblastoma multiforme Meningioma Schwannoma
whorled pattern, psammoma bodies (laminated calcifications)
Meningioma
associated with NF2
schwannoma
GFAP +
pilocytic astrocytoma, glioblastoma multiforme
rosenthal fibers- eosinophilic corkscrew fiber
pilocytic astrocytoma
compresses 4th ventricle causing hyrdocephalus
medulloblastoma, ependymoma
homer-wright rosettes - small blue cells pink center
medulloblastoma
perivascular pseudorosettes - basal ciliary bodies
ependymoma
supratenoral childhood tumor, derived from remnants of rathkes pouch
craniopharyngioma
compress CN III, eyes look down and out, dilated pupil
Uncal herniation, medial temporal lobe herniation past tentorium cerebelli
port wine stains (nevus flemmus) with V1 distribution, also leptomeningeal angiomas and pheochromocytoma
Sturge-weber syndrome
Harmatomas in CNS, ash-leaf hypopigmented spots, rhabdomyoma, mental retardation, renal angiomyolipoma, seizures
tuberous sclerosis
cafe-au-lait hyperpigmented spots, lisch nodules (iris pigmented spots), optic glioma, pheochromocytoma, chrom 17
NF1
AD, variable expression, 100% penetrant
NF1
hemangiomas in skin and organs, bilateral renal cell CA, hemangioblastoma in retina, brainstem and cerebellum, pheochromocytoma,
von-Hipple-Lindau
bilateral schwannoma, meningiomas, ependymomas
NF2
drop metastises
medulloblastoma
brainstem lesion resulting in pain and temperature loss on one side of face and opposite side of body. also dysarthria, dysphagia, ataxia
PICA - located on same side of facial lesion (wallenberg syndrome)
brain tumor in frontal lobe with seizures, muscle weakness, fried egg appearance (clear cytoplasm with dense nucleus)
oligodendoglioma
