BP Medications Flashcards
Which diuretic is most potent
Loop diuretic
Potassium sparing diuretic mechanism of action
Some of these drugs don’t act directly on sodium transport but on aldosterone receptors in the collecting duct. Others inhibit sodium channels associated with aldosterone sensitive sodium pump, which spares potassium
Thiazide diuretic mechanism of action
Inhibit the sodium chloride transporter in the distal tubule also leading to less reabsorption of sodium (5%)
ACE inhibitor mechanism of action
Inhibits angiotensin converting enzyme and prevents break down of bradykinin, which causes vasodilation and potentiates the action of ACE inhibitors
Angiotensin receptor blockers mechanism of action
Blocking angiotensin II from attaching to angiotensin II receptors in smooth muscles and adrenal glands
Beta blockers mechanism of action
Compete with epinephrine and norepinephrine for attachment to beta receptor sites, which leads to decreased sympathetic nervous system stimulation and decreased heart rate and contractility
Non selective beta blocker mechanism of action
Non-selective bind beta 1 (cardiac) and beta 2 (bronchial) receptors, which leads to bronchoconstriction
Cardio selective beta blocker mechanism of action
Cardioselective only bind beta 1 receptors and are preferred because they don’t affect the lungs
Calcium channel blockers mechanism of action
Inhibit calcium channels
Nondihydropyridine mechanism of action
Affect the heart and blood vessels
Dihydropyridine mechanism of action
Affect the vessels
Which BP medications cause potassium wasting
Loop diuretic
Thiazide diuretic
Loop diuretic mechanism of action
Inhibit the sodium- chloride-potassium cotransporter in the thick ascending limb of the loop of Henle, leading to less reabsorption (25% of sodium).
