Bordetella bronchiseptica

Question 1

specifics

Answer 1

gram -ve, small, coccobacillus, aerobic

affinity for upper resp - ciliated resp epithelium

Question 2

CS in dogs and cat

Answer 2

kennel cough 
6-7 wk old 
cats/ kittens- mortality, less severe in older animals 
prev- vaccine 2 inj, 3 week apart 
live vx- 3 weeks, nasal inoculation

Question 3

Dx in dogs and cats

Answer 3

bronchoalveolar lavage

isolation

Question 4

pathogenesis

Answer 4

endo/exogenous–> adhere to ciliated epithelium–> NH3 produced–> inflammation–> susceptible to 2* infection

Question 5

virulence factors- adhesion

Answer 5

biofilms- persistant
filamentous hemagglutinin - adhere to macrophages
pertactin- outer membrane protein
fimbrae

Question 6

virulence factor- toxin

Answer 6

hemolysin 
dermonecrotic toxic 
osteotoxin- osteoblasts 
tracehal cytotoxin
byg regulation- virulent vs. non virulent

Question 7

pigs CS

Answer 7

non progressive atrophic rhinitis- dermonecrotic toxin
progressive atrophioc rhinitis- damage to osteoblasts
skewed, shortening of nose
paired with P.multocida- high infection pressure, increase osteoclasts
pneumonic bordetellosis- <1wk of age, purulent bronchiolitis, alveolitis

Question 8

Horse

Answer 8

rare
similar to dog and cat
prev- inhalation of fungal spores, wetting, feed on floor, replace with alfalfa, prevent straw

Question 9

Dx in pigs

Answer 9

cultivate - sample nose deep swab
serology
PCR

Question 10

B.avium

Answer 10

poultry 
CS- coryza- inflammation of nasal MM (in turkeys)
resp problems 
high morb, low mort
open beak resp, head shaking 
nasal discharge and sneezing

Question 11

Bordetella in rabbits

Answer 11

nasal discharge, sneezing, coughing
conjunctivitis, blindness
ear infections, abcesses
Antibiotics lincosamides- single dose is toxic
penicillin less toxic
AB okay- neomycin, streptomycin, tetracycline, chloramphenicol, polymyxin