bones Flashcards

1
Q

characteristics of bones

A
  • low cellularity
  • EM is majority volume
  • EM of soft connective tissue is 70-75% water
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2
Q

how much of collagen is dry mass

A

60-70%

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3
Q

what are types of skeletal articular structures

A

ligaments
tendons
menisci
bones

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4
Q

ligaments

A

tether bones across joints + controls relative motion of joints (limits ROM)

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5
Q

tendons

A

connects bone to muscle + transmits muscular forces to bone
- vascular, can adapt to exercise

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6
Q

what happens to tendons if there is low blood suppluy

A

adaptations will occur slower

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7
Q

what is the structure of the tendon

A

tendon –> fasicle –> fibrils + tendon cells –> subfibril –> microcollagen –> tropocollagen

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8
Q

what does tropocollagen work together with and what is the function

A

tropocollagen works with crosslinks which are compressive filament layers that help support tendon during tension

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9
Q

menisci

A
  • maintain joint components in appropriate position, enhances rotation in synovial joints
  • reduces joint stress
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10
Q

bones

A
  • provide mechanical support
  • dynamic tissue that can fluctuate bone mineral density
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11
Q

what is the ultimate determinator of ROM

A

ligaments

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12
Q

what is the largest calcium resevoir in the body

A

bones

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13
Q

what can cause tissue turnover in bones

A

injury, excessive mechanical resistance = damaged matrix = repair and building of new matrix

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14
Q

characteristics of fibrous connective tissue

A
  • limited vascularity = slow to adapt
  • restricted metabolic capacity during matrix turnover
  • less vigorous adaptive response to stimuli than in bone
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15
Q

what type of cells are seen in fibrous connective tissue

A

fibroblasts: primary cells in tendons and ligaments repair/growth
fibrochondrocytes: primary cell of menisci

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16
Q

how does resistance training change bones

A

it can help stimulate bone repair and growth
- e.g. femoral neck gets bigger and the vertebrae get bigger

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17
Q

what kind of movements help with the most repair/growth in tendons and ligaments

A

whole body movements

18
Q

how often do bones completely turnover

A

as little as 3 yrs, but normally every 7-10 yrs

19
Q

what are the types of cells in bones

A

osteoblasts: increase BMD (must need some sort of mechanical strain in order to function)
osteocytes: maintain bone mineral density where located
osteoclasts: decrease BMD constantly active

20
Q

what type of bone cell is mainly lost with age

A

osteoblasts (esp in women bc of osteoperosis)

21
Q

when does bone modeling occurs

A

throughout childhood growthwh

22
Q

when does bone remodeling occur

A

during different activities/movements
- only parts of the bone remodel based on microfracture that occur whereas modeling is the whole bone itself

23
Q

what are factors that effect bone tissue remodeling

A
  • current BMD
  • bone strenght
24
Q

what affects someones current BMD

A
  • genetics (about 80%)
  • environmental conditions (@ sea level people have bigger bones bc it grows faster where higher altitudes grows slower that’s why people are short)
25
why does altitude affect bone growth
there isnt a lot of O2 available so cant grow as much
26
what affects bone strength
- bone mass - bone density (decreases with age) - bone size (larger bones are more resilient - bone geometry (each person has a different shape of bone
27
what are the positive effects in bone to mechanical stimulus
- increase in bone cross sectional area - reduction in bone mechanical stress (greater resistance to torsion/twisiting) - increase in BMD, bone strength, intestinal and renal calcium absorption and secretion
28
why do athletes have higher chances of kidney stones
high concentrations of calcium absorption can promote stone formation if dehydration occurs
29
negative effects of strenuous exercise
- microdamage grom prolonged bouts can lead to stress reactions and fractures
30
what is the female athlete triad
low energy/disorded eating --> menstrual disorders --> loss of BMD
31
is weight training helpful for younger individuals
yes in appropriate amounts - exercise shows increase neural connection formation rather than muscle size or BMD increase
32
what substances affect BMD
anabolics, GH, and other hormones show an increase in BMD
33
what are some things that affect exercise
- genetics - diet - homrones - development and aging
34
how does diet affect exercise
- need minerals like vit D, proteins, fat - with low or now amino acids = no collagen = no repair - not a lot of fat = function and repair is limited
35
how does hormones affect exercise and function
- things like GH and estrogen are needed for protein synthesis
36
what are the proposed strain components for adaptation in bone
- magnitidue/intensity = more microfractures - frequency - rate - gradient: load must be progressive
37
what are bone adaptations from exervise
- mechanical transduction
38
what is mechanical transduction
mechanical force/strain is used to elicit biochemical signals and transduction pathways within the body to stimulate adaptations
39
steps to mechanical transduction
- mechanical loading = stress/strain within bones - piezoelectricitiy: the changing of charge distribution within matrix, attracting osteoblasts and osteoclasts - fluid is also sensed going through canaliculi by osteocytes that recruit osteoblasts for remodeling
40
shear flow
fluid movement through microstrain
41
ion flow
movement of Mg bringing osteoblasts
42
nutrient flow
gives osteoblasts fuel