Bones Flashcards
Parts of skeletal system
- bones (osseous tissue)
- ligaments - dense regular CT, connect bone to bone
- tendons - dense regular CT, connect muscle to bone (technically part musculoskeletal system)
- cartilage - primary hyaline, fibrocartilage (between bone on bone joints)
- Connective tissue - periosteum (dense irregular)
Give two general elevations and projections
process
Any projection or bump. (acromion process)
ramus
An extension of a bone making an angle with the rest of the structure (ramus of the mandible)
Function of skeletal system
- support
- storage of minerals
- storage of lipids -> yellow marrow
- blood cell production -> red marrow
- protection
- Leverage (force of motion)
What are the six classifications of bone
- Flat bones (bones of the skull, sternum, ribs, scapulae). Sandwich of compact bone with spongy bone (diploë) in the middle
- Sutural bones - only found in skull
- irregular bones (vertebra / pelvic bone) - primarily spongy bone that is covered with a thin layer of compact bone
- short bones (tarsal and carpal bones) - consist primarily of spongy bone, which is covered by a thin layer of compact bone
- sesamoid bone (patella, pisaform) - spongy bone covered by compact bone.
- long bones (humerus (upper arm), radius / ulna (forearm), tibia (shin bone), fibular, phalanges), clavicle- primarily compact bone (diaphysis) with spongy bone at the epiphysis covered by a layer of compact bone at epiphysis.
Six processes where tendons or ligaments attach
trochanter
a large, rough projection. Found exclusively on the femur
greater / lesser trochanter of femur
tuberosity
a smaller, rough projection or a rounded prominance
deltoid tuberosity (humerus), radial tuberosity (radius), tibial tuberosity (tibia), ischial tuberosity (ischia)
tubercle
a small, rounded projection (abductor tubercle)
greater / lesser tubercle (humerus) / conoid tubercle (clavicle), costal tubercle (rib), abductor tubercle (femur)
crest
a prominent ridge (iliac crest)
iliac crest (ilia), anterior crest (tibia), intertrochanteric crest (femur)
line
A low ridge (nuchal lines of occipital bones)
mylohoid line (mandible), intertrochanteric line (femur)
spine
A pointed, narrow process (spinous process on vertebre, spine of scapula)
ischial spine (ischia), [anterior superior, anterior inferior, posterior superior, posterior inferior] + iliac spine
Five processes formed for articulation with adjacent bones
Head
expanded articular end of an epiphysis, separated from the shaft by a neck.
head of femur, fibia, humerus, ulna, radius, rib (flat bone)
no head on tibia
head of ulna is distal
Neck
A narrow connection between the epiphysis and the diaphysis. Often considered part of metaphysis.
neck of femur, anatomical / surgical neck of humerus
Condyle
A smooth, rounded articular process. forms an articulation with another bone.
occipital condyle, mandibular condyle, medial / lateral condyle (femur), medial / lateral condyle (tibia), trochlea + capitulum = condyle (humerus)
Trochlea
A smooth, grooved articular process shaped like a pulley (trochlea of humerus)
trochlea of humerus. Forms condyle with capitulum
facet
a small, flat articular surface (costal facets in thoracic vertebrae)
costal facets (vertebral body / transverse process), superior / inferior articualting facet of vertebrae
Two Depressions
Fossa
A shallow depression
- articulation, attachement, passageway
iliac fossa, mandibular fossa, olecranon fossa (humerus), coronoid fossa (medial humerus), infraspinous fossa, supraspinous fossa, subscapular fossa, intercondylar fossa (femur), lacrimal fossa, radial fossa (humerus lateral)
Ulna is medial
Sulcus
A narrow groove (intertubercular salculs (bicipital groove))
- nerve / blood vessel pasageway
Four Bone openings
foramen
a rounded passageway for blood vessels or nerves
canal or meatus
a passageway through the substance of a bone. Natural opening or canal. (internal acoustic meatus)
fissure
a narrow, elongated opening or groove. often houses nerves or blood vessels
sinus or antrum
a chamber within a bone, normally filled with air
antra -> plural. Antrum -> singular
Describe the structure of a long bone
- articular cartilage: found on the surfaces of bones that form synovial joints, such as the knees, hips, shoulders, and elbows. It covers the ends of bones where they come into contact with each other. Primarily hyaline
- epiphysis: rounded edge on long bone, primarily consists of spongy bone, thin external layer of compact bone.
- metaphysis: wide portion of a long bone, between epiphysis and diaphysis. Primarily spongy bone, thin external layer of compact bone. Where epiphyseal plate is
- diaphysis: The shaft or central part of a long bone, primarily composed of compact bone
- epiphyseal plate: A hyaline cartilage plate in the metaphysis of a growing bone, responsible for lengthwise growth. Region closest to diaphysis proximal face, region closest to epiphysis, distal face. Chondrocytes larger in proximal face. Bone invades proximal face, calcifying, killing cartilage. At the same time proliferation occurs at distal plate. Think of cartilage “outrunning” ossification, pushing out the epiphysis. The epiphysial plate closes when bone growth outpaces cartilage production.
- epiphyseal line: The remnant of the epiphyseal plate in adult bones, appearing as a line once bone growth has ceased
femur is the longest bone in the body
What is the periosteum?
what are the layers in the periosteum
- The periosteum is a dense, fibrous membrane that covers the outer surface of all bones except at the joints, where it is covered by articular cartilage. Plays a critical role in bone health, growth, repair, and overall functionality of the skeletal system
Outer Fibrous Layer
Made up of dense irregular connective tissue, containing blood vessels, nerves, and lymphatic vessels.
Inner Cellular Layer (Cambium Layer)
Contains osteoprogenitor cells, osteoblasts, mesenchymal stem cells, osteoclasts (more on bone surface), nerve cells, fibroblasts, macrophages
The periosteum directly covers the outer surface of bones, but it does not directly cover the spongy bone
What is the medullary cavity
- is the central cavity of long bones, located in the diaphysis of long bones
- houses bone marrow (red in children, yellow in adults)
- houses blood vessels
- lined by the endosteum
Describe endosteum
- thin vascular layer or connective tissue (associated with reticular ct) which lines the medullary cavity and central canals, in compact bone and the trabeculae of spongy bone
- contains a layer of connective tissue and a cellular layer with osteoprogenitor cells, osteoblasts, and osteoclasts.
the endosteum consists of a layer of flattened osteoprogenitor cells and a type-III collagenous fibers (reticular fibers). The endosteum is noticeably thinner than the periosteum
The periosteum directly covers the outer surface of bones, but it does not directly cover the spongy bone. Instead, the periosteum covers the compact bone layer that encloses the spongy bone
Spongy bone trabeculae
- Trabeculae are irregularly arranged, thin plates or struts. They form a porous network that provides structural support and strength to the bone while reducing its weight. Helps resist stresses and strains from various directions
- composed of lamellae, which are layers of bone matrix containing osteocytes (housed in lacunae). The trabeculae are surrounded by red bone marrow.
- canaliculi of spongy bone connect to the adjacent cavities, instead of a central haversian canal, to receive their blood supply
- lined by endeosteum.
- functional unit of spongy (cancellous) bone
contain trabecular lamellae
trabecula -> singular
Four types of lamellae in bone
concentric lamellae
Found in compact bone, arranged in concentric rings around central (Haversian) canals. Form osteon.
interstitial Lamellae
Found between osteons in compact bone.
circumferential Lamellae
located on the outer surfaces of compact bone, encircling the entire bone shaft.
trabecular lamellae
Found in spongy bone, forming the trabeculae
Lamellae are composed of ground substance (collagen fibers + proteins + hydroxyapatite crystals), osteocytes, and canaliculi
Components of Bone matrix
Organic Components
- collagen fibers (primarily type I). Provide tensile strength. Give bone ability to absorb shock.
- other proteins (proteoglycans and glycoproteins)
- 1/3 weight
Inorganic Components
- Hydroxyapatite crystals -> composed of calcium and phosphate and calcium hydroxide.
- small amounts of Mg (Magnesium contributes to the formation of bone matrix and plays a role in the regulation of calcium and phosphate balance), F(enhances stability / strength), Na+ (mineral balance / bone formation / structural integretiy),
- 2/3 of weight
ground substance
both organic and inorganic components of matrix.
Bones derive their flexibility from collagen fibers (Type I collagen) and their rigidity from the mineral content, primarily hydroxyapatite
Cells in Osseous Tissue
- Osteoprogenitor cells. originate from mesenchymal stem cells. Become osteoblasts . Found in periosteum, endosteum, bone marrow.
- Osteoblast. Osteogenic cells. responsible for synthesizing and secreting the bone matrix, including collagen and other proteins (primary mineralization).
- Osteocytes. Maintain bone matrix, regulate bone remodeling in response to mechanical stress. Mature osteoblasts.
- Osteoclast. Osteoclasts are large, multinucleated cells responsible for bone resorption, breaking down bone tissue by secreting acids and enzymes that dissolve the mineral components and collagen. Process essential for bone remodeling.
- Hematopoietic stem cells. Become osteoclasts. Primarily found in bone marrow
bone mineralization has two phases, primary and secondary. Primary is orchestrated by osteoblasts (secret a large amount of collagen fibrils, non-collagenous proteins, and matrix vesicles, which are extracellular vesicles that trigger mineralization via membrane transporters and enzymes). Secondary mineralization is not well understood
What is an osteon
The fundamental structural unit of compact bone. Each osteon is a cylindrical structure that helps maintain the strength and integrity of bone.
Contains:
- central canal which contains blood vessels, nerves, and lymphatic vessels. Provide nutrients. Remove waste
- Lamellae, concentric rings of bone matrix. Made of collagen fibers and mineralized ground substance (primarily hydroxyapatite)
- Lacunae: small spaces between lamellae, houses osteocytes.
- osteocyte: mature osteoblast, reside in lacunae, maintain matrix.
- canaliculi: channels radiating from lacunae, connect lacunae to each other and central canal. Allow exchange of nutrients, waste, and signals (gap junctions).
- endosteum, lines central canal
Perforating fibers
- Perforating fibers, also known as Sharpey’s fibers, are strong, collagenous fibers (primarily type I collagen) that extend from the periosteum into the underlying bone matrix
- They run perpendicular to the surface of the bone, anchoring the periosteum to the bone
- Perforating fibers firmly anchor the periosteum to the outer surface of the bone, ensuring that the periosteum remains tightly attached
Describe Endochondral Ossification
Interstitial growth Long bones
- Chondrocytes near the center of a hyaline cartilage template (which resembles the shape of the future bone) increase in size as the matrix calcifies. The chondrocytes die leaving cavities within the cartilage. This becomes the primary center of ossification.
- Blood vessels grow around the edges of the cartilage template, cells in the perichondrium convert to osteoblasts creating a superficial exterior layer of bone (bone colar).
- Blood vessels enter the central region of the calcified cartilage, bringing osteoprogenitor cells which differentiate into osteoblasts, producing spongy bone at the primary center of ossification. Bone formation spreads along the shaft towards both ends.
- As the bone remodels, the spongy bone in the primary center of ossification is resorbed by osteoclasts creating the medullary cavity.
- Capillaries and osteoblasts migrate into the epiphyses creating secondary ossification centers (normally one at each end).
- The epiphyses fills with spongy bone, hyalin cartilage persistes at end (articulating cartilage) and in epiphyseal plate. This is the site of interstitial growth.
Describe intramembranous Ossification
6 steps
Development of flat bones
also called dermal ossification
- Differentiation of Mesenchymal Cells: Mesenchymal cells in the dermis differentiate directly into osteoblasts, initiating the process of ossification.
- Formation of Bone Spicules: The osteoblasts begin secreting bone matrix, which mineralizes to form spicules (small, needle-like structures) that spread into the surrounding tissues.
- Trapping of Blood Vessels: As the spicules grow and connect, they trap blood vessels within the developing bone, ensuring a good blood supply for continued growth and development.
- Development of Spongy Bone: Over time, the network of spicules expands and connects to form trabeculae, giving the bone a spongy structure.
- Formation of Periosteum: The outer layer of mesenchymal cells condenses to form the periosteum, a membrane that covers the bone and contains osteoprogenitor cells and osteoblasts.
- Formation of Compact Bone: Osteoblasts in the periosteum continue to produce bone matrix, which eventually forms layers of compact bone on the outer surfaces of the spongy bone, providing additional strength and structure.
Describe Two types of Growth in Long Bones
Interstitial
- Growth in length.
- endochondral ossification at secondary ossifcation centers (epiphyseal plate) at the epiphysis.
- continues until epiphyseal closure.
Appositional Growth
- Growth in diameter.
- Compact bone thickens and strengthens long bone
- osteoclasts break down old tissue, osteoblasts deposit bone matrix, becomes surrounded by the matrix, become osteocytes. Occurs at endosteum or periosteum.
Describe process of interstitial growth. Include zones.
The epiphyseal plate has hyaline cartilage in the middle with a transitional zone where cartilage is replaced by bone.
- Zone of resting cartilage, consistes of typical hyalin cartilage.
- Zone of proliferating cartilage, chondrocytes multiple, arrange themselves in longitudinal columns.
- Zone of hypertrophic cartilage, chondrocytes cease to multiple, undergo hypertrophy.
- zone of calcification, minerals are deposited between the columns of lacunae, calcifying the cartilage. Not the permanent mineral deposits, temporary.
- zone of ossification: Chondrocytes die, leaving empty channels. Blood vessels invade the channels, bringing with them osteoblasts. Osteoblasts start to lay down new bone matrix on the remnants of the calcified cartilage, creating a network of spongy bone (trabecular bone). Osteoclasts break down spongy bone in center elongating the marrow cavity. Osteoblasts convert exterior spongy bone into compact bone.
Region closest to diaphysis proximal face, region closest to epiphysis, distal face. Chondrocytes larger in proximal face. Bone invades proximal face, calcifying, killing cartilage. At the same time proliferation occurs at distal plate. Think of cartilage “outrunning” ossification, pushing out the epiphysis. The epiphysial plate closes when bone growth outpaces cartilage production.
Four main sets of blood vessels in bones
- Nutrient vessels - Enter the bone through the nutrient foramen in the diaphysis of long bones. Supply inner layers of bone with nutrients.
- Metaphyseal Arteries and Veins
Found in the metaphysis, the region between the diaphysis and the epiphysis of long bones. Blood supply of the metaphyseal region and the adjacent areas of the growth plate (epiphyseal plate) - Epiphyseal Arteries and Veins:
located in the epiphysis. They provide blood to the epiphyseal regions, including the cartilage of the growth plate and the spongy bone in the epiphysis - Periosteal vessels - Located in the periosteum. Supply the outer layers of compact bone and the periosteum
Epiphyseal arteries and veins originate from periosteal arteries and veins, nutrient arteries and veins, and sometimes from metaphyseal arteries and veins. These vessels penetrate the epiphysis, supplying blood to the growth plate, spongy bone, and surrounding joint structures, ensuring the proper development and maintenance of bone tissue.
Bone remodeling
- In bone remodeling osteoblasts create new bone by synthesizing and calcifying the bone matrix. At the same time osteoclasts break down old or damaged tissue, resorbing it. Bone remodeling is a dynamic process. If deposition is greater than removal bones get stronger, if removal is faster than replacement bones get weaker
- In the first year of life almost 100% of the skeleton is replaced
- In adults about 10% of the skeleton is remodeled each year.
What are the effects of exercise on Bone
- Wolff’s law of bone states that the architecture of a bone is determined by the mechanical stress placed on it.
- When bones are heavily stressed they will become thicker and stronger, when they are not used osteocytes remove the matrix to get rid of unnecessary mass. Up to one third of bone mass can be lost in a few weeks of inactivity. This rapid loss occurs because bones rely on mechanical stress and weight-bearing activities to maintain their density and strength
Mechanical Loading: When you engage in weight-bearing activities, such as running, jumping, or resistance training, mechanical stress is applied to the bones. This stress leads to the deformation of bone tissue, which in turn stimulates the bone remodeling process. Bone remodeling involves the resorption of old bone by osteoclasts and the formation of new bone by osteoblasts Exercise influences bone density, gemotetry, and quality