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BM2_MICRO_Q4 Flashcards

1
Q

This is a folinic acid analog whose mechanism of action is inhibition of dihydrofolate reductase. Its primary use is in the treatment of Pneumocystis jirovecii infections in AIDS patients who are intolerant of or refractory to trimethoprim–sulfamethoxazole and pentamidine isethionate. *
Remdesivir
Azithromycin
Trimetrexate
Metronidazole

A

Trimetrexate

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2
Q

Cytomegalovirus affects the organs in latent infection except *
Kidneys
Glands
Lymphoid tissue
Neurons

A

Neurons

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3
Q

The common name of Human Herpes 8 is *
Epstein-Barr
Herpes Simplex
Kaposi sarcoma
Varicella-zoster

A

Kaposi sarcoma

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4
Q

Epstein Barr Virus is a member of what subfamily of the herpesviruses *
All of the above
Gamma
Alpha
Beta

A

Gamma

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5
Q

Cytomegalovirus belongs to official name ( Human Herpesvirus) *
5
7
1
3

A

5

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6
Q

Roseola infantum infects what type of lymphocytes? *
T
B
Null
Nk

A

T

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7
Q

Fatal Herpes encephalitis is closely associated with *

Herpes simplex 2
Herpes simplex 1
Epstein-Barr virus

A

Herpes simplex 1

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8
Q

Which of the following parts of the body is most commonly affected by Varicella-zoster infection? *
Neck
Head
Trunk
All of the above

A

Trunk

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9
Q

Microcephaly is associated in what Herpes virus? *
Cytomegalovirus
Herpes simplex 2
Herpes simplex 1
Roseola infantum

A

Cytomegalovirus

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10
Q

Epstein Barr virus is associated with what neoplasm? *
Lymphoma
All of the above
Gastric carcinoma
Nasopharyngeal carcinoma

A

All of the above

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11
Q

A marker of past infection and indicates immunity in Epstein Barr virus infection *
Antibodies to Early antigen
VCA IgM
VCA IgG
Heterophile

A

VCA IgG

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12
Q

Multinucleated giant cells and intranuclear inclusions in the form of Owl eye appearance are highly specific of what Herpes Virus? *

Cytomegalovirus
Varicella zoster
Kaposi Sarcoma
Herpes simples I

A

Cytomegalovirus

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13
Q

A classical picture of this virus is seen in *
Herpes Simplex
Epstein Barr virus
Herpes Simplex 1
Varicella-Zoster

A

Herpes Simplex

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14
Q

Kissing disease is associated with what Herpes virus? *
Epstein Barr
Cytomegalovirus
Varicella-zoster
Herpes simplex 1

A

Epstein Barr

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15
Q

Which of the following Hepatitis virus lead to chronicity? *
All of the above
A and E
B, C, D
B only

A

B, C, D

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16
Q

Ether and acid sensitivity are commonly found in what type of Hepatitis *
C
A and E
B
D

A

C

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17
Q

Fulminant disease is frequent in what type of Hepatitis ? *
D
C
B
A and E

A

D

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18
Q

Oncogenicity is associated with what type of Hepatitis except *
D
B
C
A

A

A

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19
Q

The only Hepatitis having DNA genome *
D
C
A and E
B

A

B

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20
Q

A common etiologic agent of post transfusion hepatitis *
B
D
C
All of the above

A

C

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21
Q

Which of the serologic antibodies in Hepatitis B is patient immune protected especially upon receiving vaccine? *
HBs Ag (+), Anti-HBc and Anti-HBs (-)
HBs Ag, Anti-HBc and Anti-HBs (-)
HBs Ag and Anti-HBc (-), Anti-HBs (+)
HBs Ag and Anti-HBc (+), Anti-HBs (-)

A

HBs Ag and Anti-HBc (-), Anti-HBs (+)

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22
Q

This causes infection only in the presence of Hepatitis virus
A
E
B
C

A

B

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23
Q

Possible Hepatitis B infection in remote past *
HBs Ag and Anti-HBs (-), Anti- HBc (+)
HBs Ag and Anti-HBc (+), Anti-HBs (-)
HBs Ag, Anti-HBc and Anti-HBs (-)
HBs Ag (+), Anti-HBc and Anti-HBs (-)

A

HBs Ag and Anti-HBs (-), Anti- HBc (+)

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24
Q

Virus vaccines are available against *
All of the above
A and B
A and E
C and D

A

A and B

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25
Q

Transmitted by fecal-oral route transmission *
All of the above
B, C, D
A and E
B, C

A

A and E

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26
Q

These causes liver cancer years after infection *
B
A
B and C
D

A

B and C

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27
Q

A member of Ebola with no mortality rate in humans and found in the Philippines *
Ivy Coast
Reston
Zaire
Sudan

A

Reston

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28
Q

Identical to Marburg virus but differ in the antigenecity *
Ebola
Lassa
Crimean Congo
Hanta

A

Ebola

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29
Q

The most lethal human pathogen among Arena virus *
Marburg
Lassa
All of the above
Rift valley

A

Lassa

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30
Q

Which can inactivate Lassa Fever virus *
Detergents
Gamma radiation
UV radiation
All of the above

A

All of the above

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31
Q

An RNA virus of arthropod borne with 3 segments
Arena
Bunya
Flavi
Filo

32
Q

The organ with the highest titers of virus is: *

Parotid gland
skin trauma
Submandibular salivary gland
Submaxillary salivary gland
CNS

A

Submaxillary salivary gland

33
Q

Orthomyxoviruses viral transcription occurs in the: *
Cytoplasm
Ribosomes
Cell
Nucleus

34
Q

Reye’s syndrome is associated with what drug? *
Paracetamol
Amoxicillin
Aspirin
Mefenamic Acid

35
Q

The etiologic agent of Bronchiolitis is: *
Respiratory syncytial virus
Adenovirus
Influenza virus
Parainfluenza virus

A

Respiratory syncytial virus

36
Q

Which of the following is not a nucleic acid based testing for viruses? *
Nucleic acid amplification
Strand displacement amplification
Enzyme immunoassay
Polymerase chain reaction

A

Enzyme immunoassay

37
Q

Treatment of exposed person to skunks: *
Observe the animal
Consider immediate prophylaxis
Go to animal bite center
None

A

Consider immediate prophylaxis

38
Q

This causes progressive multifocal leukoencephalopathy, a central nervous system complication that occurs in some immunosuppressed individuals. *

Borna virus
Hanta virus
JC virus
Prion

39
Q

Prions are sensitive to which of the following: *
Dry heat
Phenol
Urea
Formaldehyde

40
Q

A fatal, degenerative disease affecting the nervous systems of sheep and goats. The disease is characterized by the development of amyloid plaques in the central nervous system of infected animals. *
CJD
Kuru
Gerstmann-Sträussler- Scheinker syndrome
Scrapie

41
Q

A scrapie-like disease, found in mule deer and elk in the United States and Canada, Infectivity has been detected in feces of deer before they become ill; the agent is retained in the soil, where it can then be ingested by other deer and elk. *

Chronic wasting disease
Scrapie
Kuru
CJD

A

Chronic wasting disease

42
Q

Which of the following are the contents of Viral transport medium (VTM) contains a buffered salt solution, protein and saccharide nutrients, pH indicator, and antibiotics to inhibit bacterial and fungal conta *

Protein and saccharide nutrients
pH indicator and antibiotics
All of the above
Buffered salt solution

A

All of the above

43
Q

This is linked to Infectious mononucleosis, nasopharyngeal carcinoma and Burkitt’s lymphoma *
HSV-1
HSV-2
Varicella-Zoster
Epstein -Barr virus

A

Epstein -Barr virus

44
Q

Epstein Barr Virus attaches to the C3d Receptor (CD21) on the surface *
NK
B
Null
T

45
Q

The only marker of primary congenital infection of Cytomegalovirus *
IgE
IgG
IgA
IgM

46
Q

During breech delivery, the exposed areas of the baby infected with Herpes simplex are *
Chest wall and buttocks
Lower extremities
Face and scalp
Upper extremities

A

Lower extremities

47
Q

Complications of genital herpes during pregnancy include *
Preterm labor
All of the above
Severe neonatal infection
Amnionitis

A

All of the above

48
Q

Non enveloped agents with fecal-oral transmission *
B and C
B and D
All of the above
A and E

49
Q

The leading cause of non-A non-B hepatitis infection *

D
B
A
C

50
Q

This reflects viral replication in Hepatitis C *
DNA
IgG
RNA
IgM

51
Q

A flavivirus related to HCV that has been identified in post transfusion hepatitis, does not appear to be hepatotropic, does not replicate efficiently in hepatocytes, and does not cause acute or chronic hepatitis. *

Hepatitis B
Hepatitis GB virus-C (GBV-C)
Hepatitis D
Hepatitis C

A

Hepatitis GB virus-C (GBV-C)

52
Q

Which one is true about Hepatitis E *

Most people recover completely.
All of the above
Can cause serious illness in pregnant women with mortality reaching 10-30% in the 3rd trimester
The overall case-fatality rate is about 1%

A

All of the above

53
Q

Mode of transmission of Hepatitis B *
Blood transfusion
Needle sharing
All of the above
Occupational injury with contaminated sharp objects

A

All of the above

54
Q

Which one is true on the diagnosis of chronic HBV infection? *
All of the above
Presence of HBV DNA
Presence of HBsAg and E antigen
Absence of anti-HBc IgM

A

All of the above

55
Q

A defective RNA viroid that requires HBV surface antigen for full expression, replication, and transmission. *
HEV
HAV
HCV
HDV

56
Q

Serologic diagnosis of acute infection of Hepatitis B is based on the following except *

Presence of the Hepatitis Antibody
All of the above
Presence of IgM antibody to hepatitis B core antigen (anti-HBc)
Presence of hepatitis B surface antigen (HBsAg) xxx

A

Presence of the Hepatitis Antibody

57
Q

Which one is true about Hepatitis A. *
Adults occasionally develop severe infection.
Acute disease in children is mild and often asymptomatic
All of the above
IgM antibody is the most practical marker of acute infection

A

All of the above

58
Q

Which Hepatitis lead to lytic hepatocyte injury and account for most clinical cases of infectious hepatitis? *

All of the above
B and D
A and E
C

A

All of the above

59
Q

Which of the following HAV antibody is an evidence for immunity. *
M
E
A
G

60
Q

These are important routes of spread of Hepatitis B *
Sexual contact
A and B
Ingestion of contaminated food and water
Household exposure In body fluids

61
Q

Which one is true about the vaccination against Hepatitis B *
Decrease the incidence of hepatocellular carcinoma
All of the above
Sequelae are preventable
Infection is preventable

A

All of the above

62
Q

RNA virus with Sandfly morphology *
Bunya
Flavi
Arena
Filo

63
Q

Marburg and Ebola are examples of *
Bunya
Flavi
Filo
Arena

64
Q

Dengue virus is under the classification of what virus *
Flavi
Filo
Bunya
Arena

65
Q

Mode of transmission of arena virus *
Bite of ticks
Inhalation of excreta of rodents
Nosocomial transmission
All of the above

A

Inhalation of excreta of rodents

66
Q

These are all RNA viruses except *
Arena
Adeno
Bunya
Delta

67
Q

RNA viruses that replicate in the nucleus *
Delta
Influenza and Retro
Arena
Bunya

A

Influenza and Retro

68
Q

Virus causing warts *
Parvovirus B19
Human Herpes virus 6
Papillomavirus
Herpes simplex

A

Papillomavirus

69
Q

Breakbone fever is caused by *
Hanta
Dengue
Chikungunya
Ebola

70
Q

Hepatitis A is a *
Picornavirus
Hepadna
Flavivirus
Hepevirus

A

Picornavirus

71
Q

The most common cause of Mollaret’s meningitis *
Herpes simplex
Adenovirus
Cytomegalovirus
Varizella-zoster

A

Herpes simplex

72
Q

Herpes simplex virus grows well in what type of cell line? *
Mink Kung and HeLa
Rhabdomyosarcoma, Vero and Hep-2
Human fibroblasts ( WI-38, MRC-5) and Rabbit Kidney
All of the above

A

Human fibroblasts ( WI-38, MRC-5) and Rabbit Kidney

73
Q

Incubation period of cultures of Herpes simplex from central nervous system, corneal, oral and other sites should be extended for *
3 days
2 weeks
1 day
1 week

74
Q

Viral respiratory specimens are refrigerated for no longer than *
48 hours
72 hours
1 week
3 days

75
Q

Which among of the specimens is an acceptable specimen for various types of viruses as confirmation of immunohistochemistry (IHC )or a standalone diagnostic test? *

Formalin-fixed, paraffin-embedded (FFPE) tissue
Ethanol fixed, paraffin embbedded tissue
Fresh specimen
All of the above

A

Formalin-fixed, paraffin-embedded (FFPE)

76
Q

Cary-Blair media transports what type of specimen? *

All of the above
Stool
Urine
Respiratory

77
Q

Evidence of recent or current infection requires the demonstration of what antibody? *
IgM
IgA
IgD
IgG

BM2 RC (7 decks)

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