Blood - WBCs Flashcards
What are the general groups of white blood cell, how are they differentiated, and which ones are they?
- 2 General groups; based on appearance after staining
- Granular leukocytes, or granulocytes→neutrophils, eosinophils, and basophils
- Agranular leukocytes or agranulocytes→monocytes and lymphocytes
How do WBCs move to an injured area and how do they detect an area is injured?
Detect chemical signs of damage in tissues when traveling along capillaries; when this happens, they leave the bloodstream and enter the damaged area
What are the characteristics of WBCs?
- They can migrate out of the bloodstream
- They are all capable of Amoeboid movement
- They are all attracted to a specific chemical stimuli
- Neutrophils, Eosinophils, and Monocytes are capable of Phagocytosis
What is diapedesis?
Emigration, or diapedesis: White blood cells squeeze between endothelial cells and enter the surrounding tissue
What is amoeboid movement?
Gliding-like movement similar to that of an amoeba
What chemical stimuli are all WBCs attracted to?
Stimula is positive chemotaxis, which guides the WBCs to invading pathogens, damaged tissues, and other active WBCs
What is phagocytosis and what white blood cells have the ability to do this?
Neutrophils, eosinophils, and monocytes are capable of engulfing pathogens, cell debris, and other material
What are the five different types of white blood cells?
Neutrophils, Eosinophils, Basophils, Monocytes, and Lymphocytes
What is degranulation?
Engulfed pathogen fuses with lysosomes that contain digestive enzymes and small peptides called defensins
What is Leukopenia?
Inadequate numbers of WBCs
What is Leukocytosis?
Excessive numbers of WBCs
What is Leukemia?
WBC cancer
Where do WBC producing stem cells originate from?
Red Bone Marrow
What are the factors that regulate WBCs?
Colony-stimulating factors: M-CSF, G-CSF, GM-CSF, Multi-CSF
