Blood – Platelets Flashcards
What is the shape of platelets?
disc-shaped
Do platelets have nuclei?
no
What allows for platelet shape alteration?
pseudopodia
What are the 2 types of granules in platelets?
- alpha granules
- dense granules
What do alpha granules contain?
- coagulation factors
- procoagulants (ie. factor V, vWF)
- platelet-derived growth factor
- adhesion molecules
What do dense granules contain?
- ADP
- ATP
- Ca2+
- serotonin
What is thrombopoietin?
liver hormone
What does thrombopoietin do?
- stimulates megakaryocyte (precursors to platelets) production in bone marrow
- produces clotting factors
What type of replication is thrombopiesis?
endomitotic synchronous nuclear replication – replicating DNA without cell division occurring
Thrombopoiesis
When does cytoplasmic granulation occur?
- occurs at any stage during maturation
- the earlier granulation occurs, the fewer amount of platelets will be produced
What is thrombopoiesis?
generation of platelets
How does platelet formation (thrombopoiesis) occur?
- endomitotic synchronous nuclear replication – megakaryocyte maturation
- cytoplasmic granulation
- cell fragments (platelets) break off from edges of megakaryocytes
Where does platelet formation occur?
(after release from cells) occurs in bone marrow or quickly following entry into circulation
What does a normal hemostatic response do?
acts to arrest bleeding following injury to vascular tissue
What are the 3 hemostasis responses?
- reaction of blood vessels (vasoconstriction)
- immediate response to vascular injury - primary hemostasis (platelet plug)
- occurs quickly, but not sufficient - secondary hemostasis (clot formation)
What is secondary hemostasis?
clot formation – network of stable fibrin that is laid on top of platelet plug
Hemostatic Vasoconstriction
What are the 2 components of the hemostatic vasoconstriction response?
- local contractile response (vasoconstrictionm and increased tissue pressure)
- release of humoral substances
Hemostatic Vasoconstriction
What does increased tissue pressure do?
helps compress vessels and reduce their diameter
Hemostatic Vasoconstriction
What does vasoconstriction do?
reduces diameter of vessels – blood less likely to flow there
Hemostatic Vasoconstriction
What is a neurogenic spasm?
rapid, but short lasting (~60 seconds) response
Hemostatic Vasoconstriction
What is a myogenic spasm?
longer lasting response (20-30 minutes)
Hemostatic Vasoconstriction
What are the 3 humoral substances released?
- serotonin – released from activated platelets
- endothelins – released from injured endothelium
- clotting factors – blood coagulation cascade reactions
What does serotonin do?
promotes vasoconstriction
What does endothelin do?
promotes vasoconstriction