Blood-Modifying, Antineoplastic, and Immunosuppressant Drugs Flashcards
Alkylating agents
Drugs that form a linkage between a substance and DNA that causes irreversible inhibition of the DNA molecule. Used in chemotherapy treatment of cancer.
Cell cycle-nonspecific
Capable of acting in several or all cell cycles.
Cell cycle-specific
Capable of acting during a particular cell cycle phase only.
Cytotoxic
Capable of destroying cells.
Disseminated intravascular coagulation (DIC)
Widespread formation of clots (thrombi) in the microscopic blood vessels of the circulatory system. DIC occurs as a complication of a wide variety of disorders and consumes clotting factors, with resultant bleeding.
Endothelial layer
The smooth layer of epithelial cells that line blood vessels.
Erythropoietin
A glycoprotein hormone secreted mainly by the kidney; it acts on stem cells of the bone marrow to stimulate red blood cell production.
Fibrinolysis
Fibrin (clot) breakdown through the action of the enzyme plasmin.
Hybridoma
A cell culture that consists of a clone of a hybrid cell formed by fusing cells of different types, such as stimulated mouse plasma cells and myeloma cells.
Metastasis
Generally refers to the transfer of cancer cells from one site to another.
Myeloma
A malignant neoplasm of plasma cells (B lymphocytes).
Myelosuppression
Inhibition of bone marrow activity that results in decreased production of blood cells and platelets.
Thrombocytopenia
A decreased number of platelets.
Thromboembolism
The condition that occurs when thrombus material becomes dislodged and is transported by the bloodstream to another site.
Thrombus
A clot in the circulatory system.
