BLOOD GROUPS & BLOOD TYPES Flashcards
a life-saving procedure in all cases of severe loss of blood, and in life-threatening anemia
BLOOD TRANSFUSION
a CLASSIFICATION OF BLOOD based on the presence or absence of inherited antigenic substances on the surface of red blood cells (RBCs)
BLOOD TYPE / BLOOD GROUP
Blood is characterized into different blood groups, based on the presence or absence of these _____ or _____
ANTIGENS OR AGGLUTINOGENS
The ABO blood group is characterized by
TWO GLYCOLIPID ANTIGENS
two glycolipid antigens
A & B
_____ contains antibodies or agglutinins that react with non-self antigens.
BLOOD PLASMA
They are absent in a newborn
ABO ANTIBODIES
the ABO antibodies start appearing in the plasma by the age of
3 - 4 mos
BLOOD TYPE:
anti-b
TYPE A
BLOOD TYPE:
anti-a
TYPE B
BLOOD TYPE:
none anti
TYPE AB
BLOOD TYPE:
anti-a, anti-b
TYPE O
ANTIGEN:
TYPE A
A ANTIGEN
ANTIGEN:
TYPE B
B ANTIGEN
ANTIGEN:
TYPE AB
A&B ANTIGENS
ANTIGEN:
TYPE O
NONE
- If someone receives blood of the wrong type, the worst problem is the reaction of the recipient’s antibodies on the donor’s RBCs.
- When the body encounters a foreign antigen
AGGLUTINATION
the CLUMPING of RBCs due to binding of antibodies (part of the immune system) to antigen, and causes BLOCKAGE OF BLOOD VESSELS and eventually death
AGGLUTINATION
can DONATE:
type AB
AB
can DONATE:
type A
A & AB
can DONATE:
type B
B & AB
can DONATE:
type O
AB, A, B, O
can RECEIVE:
type AB
AB, A, B, O
can DONATE:
type A
A, O
can DONATE:
type B
B, O
can DONATE:
type O
O
the red cells of humans also contain an additional antigen
Rh antigen
most common & most potent Rh antigen
D
Persons whose red cells CONTAIN this additional antigen are called
Rh+
Persons whose red cells LACK this additional antigen are called
Rh-
during the second and subsequent pregnancies, the mother’s anti-Rh antibodies cross the placental membrane into the fetus where they cause agglutination and hemolysis. The clinical condition that develops in the fetus is called
HEMOLYTIC DISEASE OF THE NEW BORN / ERYTHROBLASTOSIS FETALIS
He discovered human
blood groups
KARL LANDSTEINER
AB blood group was found by
DECASTRELLO & STURLI
Antiserum A + Blood sample = Agglutination
TYPE A
Antiserum B + blood sample = Agglutination
TYPE B
Antiserum A+B + Blood sample = Agglutination
TYPE AB
Antiserum A+B + Blood sample = NO Agglutination
TYPE O
- in transfusion medicine, refers to the test that is performed PRIOR TO A BLOOD TRANSFUSION in order to determine if the donor’s blood is COMPATIBLE with the blood of an intended recipient.
- used to determineCOMPATIBILITY between a donor and recipient, in organ transplantation or blood transfusion
CROSS MATCHING
UNIVERSAL DONORS
TYPE O
UNIVERSAL RECIPIENTS
TYPE AB
The ABO-INCOMPATIBILITY between the MOTHER and FETUS rarely causes
HDN